| Tag | Content |
|---|---|
| Uniprot ID | Q8CGU9 |
| Entrez ID | 317675 |
| Genbank protein ID | AAM28947.1 |
| Genbank nucleotide ID | NM_173839.2 |
| Ensembl protein ID | ENSRNOP00000005157 |
| Ensembl nucleotide ID | ENSRNOG00000003880 |
| Gene name | Tryptophan 5-hydroxylase 2 |
| Gene symbol | Tph2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MQPAMMMFSS KYWARRGLSL DSAVPEEHQI LGGLTQNKAT ASKSEDKRSG KDTSESSKTA 60 VVFSLKNEVG GLVRALRLFQ EKHVNMLHIE SRRSRRRSSE VEIFVDCECG KTEFNELIQL 120 LKFQTTIVTL NPPDNIWTEE EELEDVPWFP RKISELDRCS HRVLMYGTEL DADHPGFKDN 180 VYRQRRKYFV DVAMGYKYGQ PIPRVEYTEE ETKTWGVVFR ELSKLYPTHA CREYLKNFPL 240 LTKYCGYRED NVPQLEDVSM FLKERSGFTV RPVAGYLSPR DFLAGLAYRV FHCTQYVRHG 300 SDPLYTPEPD TCHELLGHVP LLADPKFAQF SQEIGLASLG ASDEDVQKLA TCYFFTIEFG 360 LCKQEGQLRA YGAGLLSSIG ELKHALSDKA CVKAFDPKTT CLQECLITTF QDAYFVSESF 420 EEAKEKMRDF AKSITRPFSV YFNPYTQSIE ILKDTRSIEN VVQDLRSDLN TVCDALNKMN 480 QYLGI 485 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TPH2 | F1PGH2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TPH2 | 102174722 | A0A452DPA3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 100009684 | Q0EAB8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 121278 | Q8IWU9 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tph2 | 216343 | Q8CGV2 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | 467070 | A0A2I3TG35 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TPH2 | F1SH22 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tph2 | 317675 | Q8CGU9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tph2 | 407712 | Q1LUE3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043005 | neuron projection |
| GO:0005506 | iron ion binding |
| GO:0004510 | tryptophan 5-monooxygenase activity |
| GO:0009072 | aromatic amino acid family metabolic process |
| GO:0071285 | cellular response to lithium ion |
| GO:0007623 | circadian rhythm |
| GO:0014823 | response to activity |
| GO:0051592 | response to calcium ion |
| GO:0043627 | response to estrogen |
| GO:0051384 | response to glucocorticoid |
| GO:0031667 | response to nutrient levels |
| GO:0042427 | serotonin biosynthetic process |
| Pfam ID | Pfam Term |
|---|---|
| PF00351 | Biopterin_H |