| Tag | Content |
|---|---|
| Uniprot ID | F1PIC7 |
| Entrez ID | 480726 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_858292.4 |
| Ensembl protein ID | ENSCAFP00000029957 |
| Ensembl nucleotide ID | ENSCAFG00000020196 |
| Gene name | Heat shock protein family A (Hsp70) member 5 |
| Gene symbol | HSPA5 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKLSLVAAVL LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR 60 ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 120 EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 180 RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 240 VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 300 SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 360 LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 420 PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 480 TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 540 MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE 600 KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGDEEPAD KDEL 654 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HSPA5 | 480726 | F1PIC7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 102185663 | M4NBE4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 3309 | P11021 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hspa5 | 14828 | P20029 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HSPA5 | 464733 | H2PYQ3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 407060 | A0A480UES1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Hspa5 | 25617 | P06761 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hspa5 | Q6P3L3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0008180 | COP9 signalosome |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0034663 | endoplasmic reticulum chaperone complex |
| GO:0005788 | endoplasmic reticulum lumen |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0030176 | integral component of endoplasmic reticulum membrane |
| GO:0016020 | membrane |
| GO:0030496 | midbody |
| GO:0005739 | mitochondrion |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0016887 | ATPase activity |
| GO:0042623 | ATPase activity, coupled |
| GO:0031072 | heat shock protein binding |
| GO:0051787 | misfolded protein binding |
| GO:0019904 | protein domain specific binding |
| GO:0044183 | protein folding chaperone |
| GO:0043022 | ribosome binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0051082 | unfolded protein binding |
| GO:0042149 | cellular response to glucose starvation |
| GO:0071353 | cellular response to interleukin-4 |
| GO:0034620 | cellular response to unfolded protein |
| GO:0021680 | cerebellar Purkinje cell layer development |
| GO:0021589 | cerebellum structural organization |
| GO:0051085 | chaperone cofactor-dependent protein refolding |
| GO:0030968 | endoplasmic reticulum unfolded protein response |
| GO:0006983 | ER overload response |
| GO:0035437 | maintenance of protein localization in endoplasmic reticulum |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0030335 | positive regulation of cell migration |
| GO:0031398 | positive regulation of protein ubiquitination |
| GO:0031204 | posttranslational protein targeting to membrane, translocation |
| GO:0042026 | protein refolding |
| GO:0006986 | response to unfolded protein |
| GO:1901998 | toxin transport |
| GO:0030433 | ubiquitin-dependent ERAD pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF00012 | HSP70 |