| Tag | Content |
|---|---|
| Uniprot ID | Q6P3L3 |
| Entrez ID | |
| Genbank protein ID | AAT68067.1; AAH63946.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000131952 |
| Ensembl nucleotide ID | ENSDARG00000103846 |
| Gene name | 78 kDa glucose-regulated protein |
| Gene symbol | hspa5 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRLLCLFLLV AGSVFAEEDD KKESVGTVIG IDLGTTYSCV GVYKNGRVEI IANDQGNRIT 60 PSYVAFTTEG ERLIGDAAKN QLTSNPENTV FDAKRLIGRT WGDSSVQQDI KYFPFKVIEK 120 KNKPHIQLDI GSGQMKTFAP EEISAMVLTK MKETAEAYLG KKVTHAVVTV PAYFNDAQRQ 180 ATKDAGTIAG LNVMRIINEP TAAAIAYGLD KRDGEKNILV FDLGGGTFDV SLLTIDNGVF 240 EVVATNGDTH LGGEDFDQRV MEHFIKLYKK KTGKDVRKDN RAVQKLRREV EKAKRALSAQ 300 HQARIEIESF FEGEDFSETL TRAKFEELNM DLFRSTMKPV QKVLEDSDLK KPDIDEIVLV 360 GGSTRIPKIQ QLVKEFFNGK EPSRGINPDE AVAYGAAVQA GVLSGEEETG DLVLLDVCPL 420 TLGIETVGGV MTKLIPRNTV VPTKKSQIFS TASDNQPTVT IKVYEGERPL TKDNHLLGTF 480 DLTGIPPAPR GVPQIEVTFE IDVNGILRVT AEDKGTGNKN KITITNDQNR LTPEDIERMV 540 NEAERFADED KKLKERIDSR NELESYAYSL KNQIGDKEKL GGKLSSEDKE AIEKAVEEKI 600 EWLEAHQDAD LEEFQAKKKE LEEVVQPIVS KLYGSAGGPP PEEAEEKDEL |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HSPA5 | 480726 | F1PIC7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 102185663 | M4NBE4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 3309 | P11021 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hspa5 | 14828 | P20029 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HSPA5 | 464733 | H2PYQ3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 407060 | A0A480UES1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Hspa5 | 25617 | P06761 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hspa5 | Q6P3L3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0034663 | endoplasmic reticulum chaperone complex |
| GO:0005788 | endoplasmic reticulum lumen |
| GO:0005576 | extracellular region |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0016887 | ATPase activity |
| GO:0031072 | heat shock protein binding |
| GO:0051787 | misfolded protein binding |
| GO:0044183 | protein folding chaperone |
| GO:0051082 | unfolded protein binding |
| GO:0034620 | cellular response to unfolded protein |
| GO:0051085 | chaperone cofactor-dependent protein refolding |
| GO:0030968 | endoplasmic reticulum unfolded protein response |
| GO:0042026 | protein refolding |
| GO:0001666 | response to hypoxia |
| GO:0001878 | response to yeast |
| GO:0030433 | ubiquitin-dependent ERAD pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF00012 | HSP70 |