| Tag | Content |
|---|---|
| Uniprot ID | M4NBE4 |
| Entrez ID | 102185663 |
| Genbank protein ID | AGG79327.1 |
| Genbank nucleotide ID | XM_005687138.3; NM_001287571.1; |
| Ensembl protein ID | ENSCHIP00000030268 |
| Ensembl nucleotide ID | ENSCHIG00000025078 |
| Gene name | Heat shock 70kDa protein 5 |
| Gene symbol | HSPA5 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKLSLVAAVL LLLLGAARAE EEDKKEDVGT VVGIDLGTTY SCVGVFKNGR VEIIANDQGN 60 RITPSYVAFT PEGERLIGDA AKNQLTSNPE NTVFDAKRLI GRTWNDPSVQ QDIKFLPFKV 120 VEKKTKPYIQ VDVGGGQTKT FAPEEISAMV LTKMKETAEA YLGKKVTHAV VTVPAYFNDA 180 QRQATKDAGT IAGLNVMRII NEPTAAAIAY GLDKREGEKN ILVFDLGGGT FDVSLLTIDN 240 GVFEVVATNG DTHLGGEDFD QRVMEHFIKL YKKKTGKDVR KDNRAVQKLR REVEKAKRAL 300 SSQHQARIEI ESFYEGEDFS ETLTRAKFEE LNMDLFRSTM KPVQKVLEDS DLKKSDIDEI 360 VLVGGSTRIP KIQQLVKEFF NGKEPSRGIN PDEAVAYGAA VQAGVLSGDQ DTGDLVLLDV 420 CPLTLGIETV GGVMTKLIPR NTVVPTKKSQ IFSTASDNQP TVTIKVYEGE RPLTKDNHLL 480 GTFDLTGIPP APRGVPQIEV TFEIDVNGIL RVTAEDKGTG NKNKITITND QNRLTPEEIE 540 RMVNDAEKFA EEDKKLKERI DTRNELESYA YSLKNQIGDK EKLGGKLSSE DKETMEKAVE 600 EKIEWLESHQ DADIEDFKAK KKELEEIVQP IISKLYGSAG PPPTNEEEAA DKDEL 655 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HSPA5 | 480726 | F1PIC7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 102185663 | M4NBE4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 3309 | P11021 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hspa5 | 14828 | P20029 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HSPA5 | 464733 | H2PYQ3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 407060 | A0A480UES1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Hspa5 | 25617 | P06761 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hspa5 | Q6P3L3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0008180 | COP9 signalosome |
| GO:0005829 | cytosol |
| GO:0034663 | endoplasmic reticulum chaperone complex |
| GO:0005788 | endoplasmic reticulum lumen |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0030176 | integral component of endoplasmic reticulum membrane |
| GO:0030496 | midbody |
| GO:0005739 | mitochondrion |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0016887 | ATPase activity |
| GO:0051787 | misfolded protein binding |
| GO:0019904 | protein domain specific binding |
| GO:0043022 | ribosome binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0042149 | cellular response to glucose starvation |
| GO:0071353 | cellular response to interleukin-4 |
| GO:0021680 | cerebellar Purkinje cell layer development |
| GO:0021589 | cerebellum structural organization |
| GO:0030968 | endoplasmic reticulum unfolded protein response |
| GO:0006983 | ER overload response |
| GO:0035437 | maintenance of protein localization in endoplasmic reticulum |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0030335 | positive regulation of cell migration |
| GO:0031398 | positive regulation of protein ubiquitination |
| GO:0031204 | posttranslational protein targeting to membrane, translocation |
| GO:0051603 | proteolysis involved in cellular protein catabolic process |
| GO:1901998 | toxin transport |
| Pfam ID | Pfam Term |
|---|---|
| PF00012 | HSP70 |