| Tag | Content |
|---|---|
| Uniprot ID | P20029; O35642; Q3UFF2; Q61630; |
| Entrez ID | 14828 |
| Genbank protein ID | BAC36166.1; BAE28609.1; BAE40825.1; CAA05361.1; BAA11462.1; AAH50927.1; BAE30882.1; AAA37315.1; BAE27328.1; BAE30576.1; AAA37742.1; BAE38982.1; AAA76734.1; |
| Genbank nucleotide ID | NM_022310.3; NM_001163434.1; |
| Ensembl protein ID | ENSMUSP00000028222; ENSMUSP00000097747; |
| Ensembl nucleotide ID | ENSMUSG00000026864 |
| Gene name | Endoplasmic reticulum chaperone BiP |
| Gene symbol | Hspa5 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 22821687 |
| Functional description | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). |
| Sequence | MMKFTVVAAA LLLLGAVRAE EEDKKEDVGT VVGIDLGTTY SCVGVFKNGR VEIIANDQGN 60 RITPSYVAFT PEGERLIGDA AKNQLTSNPE NTVFDAKRLI GRTWNDPSVQ QDIKFLPFKV 120 VEKKTKPYIQ VDIGGGQTKT FAPEEISAMV LTKMKETAEA YLGKKVTHAV VTVPAYFNDA 180 QRQATKDAGT IAGLNVMRII NEPTAAAIAY GLDKREGEKN ILVFDLGGGT FDVSLLTIDN 240 GVFEVVATNG DTHLGGEDFD QRVMEHFIKL YKKKTGKDVR KDNRAVQKLR REVEKAKRAL 300 SSQHQARIEI ESFFEGEDFS ETLTRAKFEE LNMDLFRSTM KPVQKVLEDS DLKKSDIDEI 360 VLVGGSTRIP KIQQLVKEFF NGKEPSRGIN PDEAVAYGAA VQAGVLSGDQ DTGDLVLLDV 420 CPLTLGIETV GGVMTKLIPR NTVVPTKKSQ IFSTASDNQP TVTIKVYEGE RPLTKDNHLL 480 GTFDLTGIPP APRGVPQIEV TFEIDVNGIL RVTAEDKGTG NKNKITITND QNRLTPEEIE 540 RMVNDAEKFA EEDKKLKERI DTRNELESYA YSLKNQIGDK EKLGGKLSSE DKETMEKAVE 600 EKIEWLESHQ DADIEDFKAK KKELEEIVQP IISKLYGSGG PPPTGEEDTS EKDEL 655 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HSPA5 | 480726 | F1PIC7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 102185663 | M4NBE4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HSPA5 | 3309 | P11021 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hspa5 | 14828 | P20029 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HSPA5 | 464733 | H2PYQ3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 407060 | A0A480UES1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Hspa5 | 25617 | P06761 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hspa5 | Q6P3L3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | ISO |
| GO:0005524 | ATP binding | IBA |
| GO:0016887 | ATPase activity | ISS |
| GO:0016887 | ATPase activity | ISO |
| GO:0016887 | ATPase activity | IBA |
| GO:0019899 | enzyme binding | ISO |
| GO:0019904 | protein domain specific binding | ISO |
| GO:0031072 | heat shock protein binding | IBA |
| GO:0031625 | ubiquitin protein ligase binding | ISO |
| GO:0042623 | ATPase activity, coupled | IBA |
| GO:0043022 | ribosome binding | IDA |
| GO:0044183 | protein folding chaperone | IBA |
| GO:0051082 | unfolded protein binding | ISO |
| GO:0051082 | unfolded protein binding | IBA |
| GO:0051787 | misfolded protein binding | ISO |
| GO:0051787 | misfolded protein binding | IDA |
| GO:0051787 | misfolded protein binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001554 | luteolysis | IEA |
| GO:0006983 | ER overload response | IDA |
| GO:0006986 | response to unfolded protein | IBA |
| GO:0010976 | positive regulation of neuron projection development | ISO |
| GO:0021589 | cerebellum structural organization | IMP |
| GO:0021680 | cerebellar Purkinje cell layer development | IMP |
| GO:0030182 | neuron differentiation | IEA |
| GO:0030335 | positive regulation of cell migration | ISS |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0030433 | ubiquitin-dependent ERAD pathway | IBA |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IGI |
| GO:0030968 | endoplasmic reticulum unfolded protein response | IMP |
| GO:0030968 | endoplasmic reticulum unfolded protein response | IBA |
| GO:0031204 | posttranslational protein targeting to membrane, translocation | ISS |
| GO:0031204 | posttranslational protein targeting to membrane, translocation | ISO |
| GO:0031333 | negative regulation of protein-containing complex assembly | ISS |
| GO:0031398 | positive regulation of protein ubiquitination | IMP |
| GO:0034620 | cellular response to unfolded protein | IBA |
| GO:0034976 | response to endoplasmic reticulum stress | ISO |
| GO:0035437 | maintenance of protein localization in endoplasmic reticulum | ISS |
| GO:0035437 | maintenance of protein localization in endoplasmic reticulum | ISO |
| GO:0035690 | cellular response to drug | IEA |
| GO:0040019 | positive regulation of embryonic development | TAS |
| GO:0042026 | protein refolding | IBA |
| GO:0042149 | cellular response to glucose starvation | ISO |
| GO:0042220 | response to cocaine | IEA |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0051085 | chaperone cofactor-dependent protein refolding | IBA |
| GO:0051402 | neuron apoptotic process | IEA |
| GO:0051603 | proteolysis involved in cellular protein catabolic process | IDA |
| GO:0071236 | cellular response to antibiotic | IEA |
| GO:0071277 | cellular response to calcium ion | IEA |
| GO:0071287 | cellular response to manganese ion | IEA |
| GO:0071320 | cellular response to cAMP | IEA |
| GO:0071353 | cellular response to interleukin-4 | IDA |
| GO:0071480 | cellular response to gamma radiation | IEA |
| GO:0097501 | stress response to metal ion | IEA |
| GO:1901998 | toxin transport | IMP |
| GO:1903895 | negative regulation of IRE1-mediated unfolded protein response | ISS |
| GO:1904313 | response to methamphetamine hydrochloride | IEA |
| GO:1990090 | cellular response to nerve growth factor stimulus | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | TAS |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IBA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IBA |
| GO:0005739 | mitochondrion | ISS |
| GO:0005739 | mitochondrion | ISO |
| GO:0005783 | endoplasmic reticulum | ISO |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005788 | endoplasmic reticulum lumen | ISO |
| GO:0005788 | endoplasmic reticulum lumen | IDA |
| GO:0005788 | endoplasmic reticulum lumen | IBA |
| GO:0005788 | endoplasmic reticulum lumen | TAS |
| GO:0005789 | endoplasmic reticulum membrane | IDA |
| GO:0005790 | smooth endoplasmic reticulum | ISO |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | ISO |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA |
| GO:0005829 | cytosol | ISS |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0009986 | cell surface | IDA |
| GO:0016020 | membrane | IBA |
| GO:0016020 | membrane | ISO |
| GO:0030176 | integral component of endoplasmic reticulum membrane | ISO |
| GO:0030496 | midbody | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0034663 | endoplasmic reticulum chaperone complex | ISO |
| GO:0034663 | endoplasmic reticulum chaperone complex | IDA |
| GO:0034663 | endoplasmic reticulum chaperone complex | IBA |
| GO:0043209 | myelin sheath | HDA |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0008180 | COP9 signalosome | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-2262752 | Cellular responses to stress | IEA |
| R-MMU-3371453 | Regulation of HSF1-mediated heat shock response | IEA |
| R-MMU-3371556 | Cellular response to heat stress | IEA |
| R-MMU-8953897 | Cellular responses to external stimuli | IEA |
| R-MMU-983169 | Class I MHC mediated antigen processing & presentation | IEA |
| R-MMU-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0067 | ATP-binding |
| KW-0143 | Chaperone |
| KW-0963 | Cytoplasm |
| KW-0903 | Direct protein sequencing |
| KW-0256 | Endoplasmic reticulum |
| KW-0378 | Hydrolase |
| KW-1017 | Isopeptide bond |
| KW-0488 | Methylation |
| KW-0944 | Nitration |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0832 | Ubl conjugation |
| Pfam ID | Pfam Term |
|---|---|
| PF00012 | HSP70 |