| Tag | Content |
|---|---|
| Uniprot ID | F1QAD6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000069635 |
| Ensembl nucleotide ID | ENSDARG00000019995 |
| Gene name | Bone morphogenetic protein 4 |
| Gene symbol | bmp4 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MIPGNRMLMV ILLCQVLLGE SSYASLIPEE GKKKASALHL AQSHELLRDF EATLLHMFGL 60 QRRPRPSHSA VVPQYLLDLY RLQSGELEEA GAQHVSFDYP ERSTSRANTV RGFHHEEHLE 120 ELQSDSSQET PLRFVFNLSS IPEDELISTA ELRVYRQQID DAFSDPDQTG DHGLHRINIY 180 EVLKAPREGQ LITQLLDTRL VRHNTSKWES FDVSPAVLRW TQEKRSNHGL AVEVVQMKRN 240 PVQKGRHVRV SRSVHPLPDE EWDQLRPLLV TFGHDGKSHP LTRRAKRSPK QRGRKRNRNC 300 RRHALYVDFS DVGWNDWIVA PPGYQAYYCH GECPFPLADH LNSTNHAIVQ TLVNSVNTNI 360 PKACCVPTEL SAISMLYLDE TDRVVLKNYQ EMVVEGCGCR |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMP4 | 407216 | Q2KJH1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 490695 | F1PDL1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 100860789 | A0A2Z4FRB3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 100034048 | F6QG82 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 652 | P12644 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Bmp4 | 12159 | P21275 | CPO,CLO | E11.5, E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | BMP4 | 100113425 | A7LJT9 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 100009569 | G1T0L5 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmp4 | 25296 | Q6AYU9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | bmp4 | F1QAD6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0070700 | BMP receptor binding |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0061312 | BMP signaling pathway involved in heart development |
| GO:0003303 | BMP signaling pathway involved in heart jogging |
| GO:0060803 | BMP signaling pathway involved in mesodermal cell fate specification |
| GO:0045165 | cell fate commitment |
| GO:0035844 | cloaca development |
| GO:0061371 | determination of heart left/right asymmetry |
| GO:0007368 | determination of left/right symmetry |
| GO:0071910 | determination of liver left/right asymmetry |
| GO:0035469 | determination of pancreatic left/right asymmetry |
| GO:0048264 | determination of ventral identity |
| GO:0048565 | digestive tract development |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0035125 | embryonic anal fin morphogenesis |
| GO:0035162 | embryonic hemopoiesis |
| GO:0007507 | heart development |
| GO:0003146 | heart jogging |
| GO:0001947 | heart looping |
| GO:0001707 | mesoderm formation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0042664 | negative regulation of endodermal cell fate specification |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0060034 | notochord cell differentiation |
| GO:0030903 | notochord development |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0003342 | proepicardium development |
| GO:0048793 | pronephros development |
| GO:0060395 | SMAD protein signal transduction |