| Tag | Content |
|---|---|
| Uniprot ID | Q2KJH1 |
| Entrez ID | 407216 |
| Genbank protein ID | AAI05345.1 |
| Genbank nucleotide ID | XM_005211793.3; NM_001045877.1; XM_005211794.3; XM_010809329.2; XM_010809331.2; |
| Ensembl protein ID | ENSBTAP00000004992 |
| Ensembl nucleotide ID | ENSBTAG00000003835 |
| Gene name | Bone morphogenetic protein 4 |
| Gene symbol | BMP4 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). |
| Sequence | MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 60 LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQI QGIGLEYPER PASRANTVRS 120 FHHEEHLENI PGTSENSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWDQGFHRIN 180 IYEVMKPPAE VVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 240 HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHALTRRRR AKRSPKHHPQ 300 RARKKNKNCR RHSLYVDFSD VGWNDWIVAP PGYQAFYCHG DCPFPLADHL NSTNHAIVQT 360 LVNSVNSSIP KACCVPTELS AISMLYLDEY DKVVLKNYQE MVVEGCGCR 409 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMP4 | 407216 | Q2KJH1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 490695 | F1PDL1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 100860789 | A0A2Z4FRB3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 100034048 | F6QG82 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 652 | P12644 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Bmp4 | 12159 | P21275 | CPO,CLO | E11.5, E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | BMP4 | 100113425 | A7LJT9 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | BMP4 | 100009569 | G1T0L5 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmp4 | 25296 | Q6AYU9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | bmp4 | F1QAD6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0070700 | BMP receptor binding |
| GO:0042056 | chemoattractant activity |
| GO:0039706 | co-receptor binding |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0000186 | activation of MAPKK activity |
| GO:0009948 | anterior/posterior axis specification |
| GO:0003180 | aortic valve morphogenesis |
| GO:0002043 | blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| GO:0030509 | BMP signaling pathway |
| GO:0061312 | BMP signaling pathway involved in heart development |
| GO:0003130 | BMP signaling pathway involved in heart induction |
| GO:0071893 | BMP signaling pathway involved in nephric duct formation |
| GO:0061151 | BMP signaling pathway involved in renal system segmentation |
| GO:0061149 | BMP signaling pathway involved in ureter morphogenesis |
| GO:0060442 | branching involved in prostate gland morphogenesis |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0060433 | bronchus development |
| GO:0060503 | bud dilation involved in lung branching |
| GO:0060449 | bud elongation involved in lung branching |
| GO:0055007 | cardiac muscle cell differentiation |
| GO:0002062 | chondrocyte differentiation |
| GO:0060197 | cloacal septation |
| GO:0007182 | common-partner SMAD protein phosphorylation |
| GO:0060976 | coronary vasculature development |
| GO:0060363 | cranial suture morphogenesis |
| GO:0035993 | deltoid tuberosity development |
| GO:0021904 | dorsal/ventral neural tube patterning |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0060272 | embryonic skeletal joint morphogenesis |
| GO:0003197 | endocardial cushion development |
| GO:0001958 | endochondral ossification |
| GO:0007492 | endoderm development |
| GO:0060502 | epithelial cell proliferation involved in lung morphogenesis |
| GO:0060684 | epithelial-mesenchymal cell signaling |
| GO:0030218 | erythrocyte differentiation |
| GO:0007281 | germ cell development |
| GO:0072104 | glomerular capillary formation |
| GO:0072015 | glomerular visceral epithelial cell development |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0060113 | inner ear receptor cell differentiation |
| GO:0048392 | intermediate mesodermal cell differentiation |
| GO:0001822 | kidney development |
| GO:0060235 | lens induction in camera-type eye |
| GO:0048286 | lung alveolus development |
| GO:0002320 | lymphoid progenitor cell differentiation |
| GO:0030225 | macrophage differentiation |
| GO:0060592 | mammary gland formation |
| GO:0003149 | membranous septum morphogenesis |
| GO:0072161 | mesenchymal cell differentiation involved in kidney development |
| GO:0072198 | mesenchymal cell proliferation involved in ureter development |
| GO:0072138 | mesenchymal cell proliferation involved in ureteric bud development |
| GO:0003337 | mesenchymal to epithelial transition involved in metanephros morphogenesis |
| GO:0007500 | mesodermal cell fate determination |
| GO:0001823 | mesonephros development |
| GO:0072205 | metanephric collecting duct development |
| GO:0030224 | monocyte differentiation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0072097 | negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway |
| GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis |
| GO:0045786 | negative regulation of cell cycle |
| GO:0060548 | negative regulation of cell death |
| GO:2000137 | negative regulation of cell proliferation involved in heart morphogenesis |
| GO:0032331 | negative regulation of chondrocyte differentiation |
| GO:0050680 | negative regulation of epithelial cell proliferation |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0072125 | negative regulation of glomerular mesangial cell proliferation |
| GO:0090194 | negative regulation of glomerulus development |
| GO:0033088 | negative regulation of immature T cell proliferation in thymus |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0072200 | negative regulation of mesenchymal cell proliferation involved in ureter development |
| GO:2000007 | negative regulation of metanephric comma-shaped body morphogenesis |
| GO:2000005 | negative regulation of metanephric S-shaped body morphogenesis |
| GO:0045839 | negative regulation of mitotic nuclear division |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0042326 | negative regulation of phosphorylation |
| GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| GO:0060686 | negative regulation of prostatic bud formation |
| GO:0045843 | negative regulation of striated muscle tissue development |
| GO:0070244 | negative regulation of thymocyte apoptotic process |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001843 | neural tube closure |
| GO:0048663 | neuron fate commitment |
| GO:0042476 | odontogenesis |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0001649 | osteoblast differentiation |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0061626 | pharyngeal arch artery morphogenesis |
| GO:0021983 | pituitary gland development |
| GO:0050918 | positive chemotaxis |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0061047 | positive regulation of branching involved in lung morphogenesis |
| GO:0055020 | positive regulation of cardiac muscle fiber development |
| GO:1905312 | positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO:0061036 | positive regulation of cartilage development |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:1901964 | positive regulation of cell proliferation involved in outflow tract morphogenesis |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0045603 | positive regulation of endothelial cell differentiation |
| GO:0010595 | positive regulation of endothelial cell migration |
| GO:0001938 | positive regulation of endothelial cell proliferation |
| GO:0045606 | positive regulation of epidermal cell differentiation |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0090184 | positive regulation of kidney development |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA |
| GO:0032092 | positive regulation of protein binding |
| GO:0060391 | positive regulation of SMAD protein signal transduction |
| GO:0048661 | positive regulation of smooth muscle cell proliferation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0009791 | post-embryonic development |
| GO:0034504 | protein localization to nucleus |
| GO:0061155 | pulmonary artery endothelial tube morphogenesis |
| GO:0003184 | pulmonary valve morphogenesis |
| GO:0060687 | regulation of branching involved in prostate gland morphogenesis |
| GO:0010453 | regulation of cell fate commitment |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth |
| GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0042306 | regulation of protein import into nucleus |
| GO:0051150 | regulation of smooth muscle cell differentiation |
| GO:0003014 | renal system process |
| GO:0003139 | secondary heart field specification |
| GO:0060395 | SMAD protein signal transduction |
| GO:0048745 | smooth muscle tissue development |
| GO:0007224 | smoothened signaling pathway |
| GO:0010159 | specification of animal organ position |
| GO:0072101 | specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway |
| GO:0043401 | steroid hormone mediated signaling pathway |
| GO:0021978 | telencephalon regionalization |
| GO:0035990 | tendon cell differentiation |
| GO:0060440 | trachea formation |
| GO:0003323 | type B pancreatic cell development |
| GO:0072192 | ureter epithelial cell differentiation |
| GO:0072193 | ureter smooth muscle cell differentiation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0891 | Chondrogenesis |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0202 | Cytokine |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0272 | Extracellular matrix |
| KW-0325 | Glycoprotein |
| KW-0339 | Growth factor |
| KW-0892 | Osteogenesis |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |