Gene: Bmp4

Basic information

Tag Content
Uniprot ID P21275
Entrez ID 12159
Genbank protein ID CAA40179.1; AAC37698.1; AAH52846.1; AAB28021.1; AAH34053.1; AAH13459.1; BAA03555.1;
Genbank nucleotide ID XM_006518467.3; XM_011244935.2; XM_006518468.3; XM_011244934.2; NM_001316360.1; NM_007554.3;
Ensembl protein ID ENSMUSP00000098242; ENSMUSP00000073720;
Ensembl nucleotide ID ENSMUSG00000021835
Gene name Bone morphogenetic protein 4
Gene symbol Bmp4
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO,CLO
Developmental stage E11.5, E12.5, E13.5, E14.5, E15.5, E16.5
Data sources Manually collected
Reference 30235284; 15716346; 27933520; 24785830; 22219353;
Functional description Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
Sequence
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 60
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS 120
FHHEEHLENI PGTSESSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN 180
IYEVMKPPAE MVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 240
HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 300
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 360
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR 408

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBMP4407216Q2KJH1Bos taurusPredictionMore>>
1:1 orthologBMP4490695F1PDL1Canis lupus familiarisPredictionMore>>
1:1 orthologBMP4100860789A0A2Z4FRB3Capra hircusPredictionMore>>
1:1 orthologBMP4100034048F6QG82Equus caballusPredictionMore>>
1:1 orthologBMP4652P12644CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologBmp412159P21275CPO,CLOE11.5, E12.5, E13.5, E14.5, E15.5, E16.5Mus musculusPublicationMore>>
1:1 orthologBMP4100113425A7LJT9Sus scrofaPredictionMore>>
1:1 orthologBMP4100009569G1T0L5Oryctolagus cuniculusPredictionMore>>
1:1 orthologBmp425296Q6AYU9Rattus norvegicusPredictionMore>>
1:1 orthologbmp4F1QAD6Danio rerioPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
BMP4rs17563; c.538T>CPolymerase chain reaction-restriction fragment length polymorphism 26424979
BMP4rs17563 C allelePCR-RFLP23227324
BMP4rs17563Real-time polymerase chain reaction using the Taqman assay method23237431
BMP4rs10130587Genotyping22514733
BMP4rs2738265Genotyping22514733
BMP4rs2761887Genotyping22514733
BMP4rs762642Genotyping22514733
BMP4c.-5514G > APCR22182590
BMP4c.-5365C > TPCR22182590
BMP4c.-5049C > TPCR22182590
BMP4rs2855530PCR22182590
BMP4rs17563Genotyping19914800
BMP4rs762642TDT19839778
BMP4rs2855532TDT19839778
BMP4rs1957860TDT19839778
BMP4c.538T>CPCR; RFLP18771417
BMP4rs17563GWAS3221112
BMP4rs762642T>GDirect sequencing; PCR29860186
BMP4rs17563T>CDirect sequencing; PCR29860186
BMP4rs10130587C>GDirect sequencing; PCR29860186
BMP4rs35107139T>GDirect sequencing; PCR29860186
BMP4c.455T>C; p.V152AWES and Sanger sequencing26449438

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005125 cytokine activityISO
GO:0005125 cytokine activityIBA
GO:0005515 protein bindingIPI
GO:0008083 growth factor activityISO
GO:0008201 heparin bindingIDA
GO:0039706 co-receptor bindingISO
GO:0042056 chemoattractant activityISS
GO:0042056 chemoattractant activityISO
GO:0042802 identical protein bindingISO
GO:0070700 BMP receptor bindingISS
GO:0070700 BMP receptor bindingIBA
GO:0070700 BMP receptor bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIIMP
GO:0000122 negative regulation of transcription by RNA polymerase IIIBA
GO:0000122 negative regulation of transcription by RNA polymerase IIISO
GO:0000122 negative regulation of transcription by RNA polymerase IIIDA
GO:0000186 activation of MAPKK activityISS
GO:0000186 activation of MAPKK activityISO
GO:0001501 skeletal system developmentIDA
GO:0001501 skeletal system developmentIMP
GO:0001525 angiogenesisIMP
GO:0001541 ovarian follicle developmentISO
GO:0001568 blood vessel developmentIDA
GO:0001649 osteoblast differentiationISS
GO:0001649 osteoblast differentiationISO
GO:0001649 osteoblast differentiationIDA
GO:0001656 metanephros developmentIDA
GO:0001656 metanephros developmentIMP
GO:0001657 ureteric bud developmentISO
GO:0001657 ureteric bud developmentIDA
GO:0001657 ureteric bud developmentIMP
GO:0001658 branching involved in ureteric bud morphogenesisISS
GO:0001658 branching involved in ureteric bud morphogenesisISO
GO:0001658 branching involved in ureteric bud morphogenesisIGI
GO:0001707 mesoderm formationIDA
GO:0001759 organ inductionIMP
GO:0001822 kidney developmentISS
GO:0001822 kidney developmentISO
GO:0001822 kidney developmentIGI
GO:0001822 kidney developmentIMP
GO:0001823 mesonephros developmentISS
GO:0001843 neural tube closureIDA
GO:0001934 positive regulation of protein phosphorylationISO
GO:0001934 positive regulation of protein phosphorylationIMP
GO:0001936 regulation of endothelial cell proliferationTAS
GO:0001938 positive regulation of endothelial cell proliferationISS
GO:0001938 positive regulation of endothelial cell proliferationISO
GO:0001938 positive regulation of endothelial cell proliferationIDA
GO:0001944 vasculature developmentIMP
GO:0001958 endochondral ossificationIMP
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesisISS
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesisISO
GO:0002062 chondrocyte differentiationIMP
GO:0002244 hematopoietic progenitor cell differentiationISS
GO:0002244 hematopoietic progenitor cell differentiationISO
GO:0002244 hematopoietic progenitor cell differentiationIDA
GO:0002320 lymphoid progenitor cell differentiationISS
GO:0002320 lymphoid progenitor cell differentiationISO
GO:0003014 renal system processIMP
GO:0003130 BMP signaling pathway involved in heart inductionISS
GO:0003130 BMP signaling pathway involved in heart inductionISO
GO:0003139 secondary heart field specificationISS
GO:0003139 secondary heart field specificationISO
GO:0003148 outflow tract septum morphogenesisIMP
GO:0003149 membranous septum morphogenesisIMP
GO:0003151 outflow tract morphogenesisIGI
GO:0003180 aortic valve morphogenesisIMP
GO:0003184 pulmonary valve morphogenesisIMP
GO:0003197 endocardial cushion developmentIMP
GO:0003323 type B pancreatic cell developmentISS
GO:0003323 type B pancreatic cell developmentISO
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesisISS
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesisISO
GO:0007182 common-partner SMAD protein phosphorylationISS
GO:0007182 common-partner SMAD protein phosphorylationISO
GO:0007224 smoothened signaling pathwayIEA
GO:0007281 germ cell developmentIMP
GO:0007492 endoderm developmentIDA
GO:0007500 mesodermal cell fate determinationIMP
GO:0007507 heart developmentIMP
GO:0008284 positive regulation of cell population proliferationISS
GO:0008284 positive regulation of cell population proliferationISO
GO:0008284 positive regulation of cell population proliferationIMP
GO:0008285 negative regulation of cell population proliferationIGI
GO:0008285 negative regulation of cell population proliferationISO
GO:0009791 post-embryonic developmentISO
GO:0009791 post-embryonic developmentIMP
GO:0009888 tissue developmentIGI
GO:0009948 anterior/posterior axis specificationIGI
GO:0010159 specification of animal organ positionIMP
GO:0010453 regulation of cell fate commitmentISS
GO:0010453 regulation of cell fate commitmentISO
GO:0010468 regulation of gene expressionIDA
GO:0010468 regulation of gene expressionIMP
GO:0010524 positive regulation of calcium ion transport into cytosolISO
GO:0010595 positive regulation of endothelial cell migrationISS
GO:0010595 positive regulation of endothelial cell migrationISO
GO:0010595 positive regulation of endothelial cell migrationTAS
GO:0010628 positive regulation of gene expressionISO
GO:0010628 positive regulation of gene expressionIMP
GO:0010628 positive regulation of gene expressionIDA
GO:0010629 negative regulation of gene expressionISO
GO:0010629 negative regulation of gene expressionIDA
GO:0010718 positive regulation of epithelial to mesenchymal transitionIGI
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylationISS
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylationISO
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylationIBA
GO:0010942 positive regulation of cell deathISO
GO:0010976 positive regulation of neuron projection developmentISO
GO:0021537 telencephalon developmentISO
GO:0021904 dorsal/ventral neural tube patterningIDA
GO:0021978 telencephalon regionalizationIGI
GO:0021978 telencephalon regionalizationIDA
GO:0021983 pituitary gland developmentIMP
GO:0030218 erythrocyte differentiationIDA
GO:0030224 monocyte differentiationISO
GO:0030225 macrophage differentiationISO
GO:0030324 lung developmentIMP
GO:0030326 embryonic limb morphogenesisIGI
GO:0030326 embryonic limb morphogenesisIMP
GO:0030335 positive regulation of cell migrationIMP
GO:0030501 positive regulation of bone mineralizationISO
GO:0030501 positive regulation of bone mineralizationISS
GO:0030509 BMP signaling pathwayISS
GO:0030509 BMP signaling pathwayISO
GO:0030509 BMP signaling pathwayIDA
GO:0030509 BMP signaling pathwayIGI
GO:0030509 BMP signaling pathwayIBA
GO:0030513 positive regulation of BMP signaling pathwayIDA
GO:0030900 forebrain developmentIGI
GO:0030900 forebrain developmentIMP
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathwayTAS
GO:0032092 positive regulation of protein bindingISO
GO:0032331 negative regulation of chondrocyte differentiationIDA
GO:0032967 positive regulation of collagen biosynthetic processISS
GO:0032967 positive regulation of collagen biosynthetic processISO
GO:0033085 negative regulation of T cell differentiation in thymusISO
GO:0033088 negative regulation of immature T cell proliferation in thymusISS
GO:0033088 negative regulation of immature T cell proliferation in thymusISO
GO:0034504 protein localization to nucleusISS
GO:0034504 protein localization to nucleusISO
GO:0034599 cellular response to oxidative stressISO
GO:0035116 embryonic hindlimb morphogenesisIGI
GO:0035990 tendon cell differentiationIMP
GO:0035993 deltoid tuberosity developmentIMP
GO:0042306 regulation of protein import into nucleusISO
GO:0042326 negative regulation of phosphorylationISS
GO:0042326 negative regulation of phosphorylationISO
GO:0042475 odontogenesis of dentin-containing toothIDA
GO:0042475 odontogenesis of dentin-containing toothIGI
GO:0042476 odontogenesisISS
GO:0042476 odontogenesisISO
GO:0042487 regulation of odontogenesis of dentin-containing toothIGI
GO:0042733 embryonic digit morphogenesisIGI
GO:0043010 camera-type eye developmentIGI
GO:0043010 camera-type eye developmentIMP
GO:0043065 positive regulation of apoptotic processISS
GO:0043065 positive regulation of apoptotic processISO
GO:0043066 negative regulation of apoptotic processISS
GO:0043066 negative regulation of apoptotic processISO
GO:0043066 negative regulation of apoptotic processIMP
GO:0043066 negative regulation of apoptotic processIBA
GO:0043401 steroid hormone mediated signaling pathwayISS
GO:0043401 steroid hormone mediated signaling pathwayISO
GO:0043407 negative regulation of MAP kinase activityISS
GO:0043407 negative regulation of MAP kinase activityISO
GO:0045165 cell fate commitmentIDA
GO:0045595 regulation of cell differentiationISO
GO:0045595 regulation of cell differentiationIGI
GO:0045597 positive regulation of cell differentiationIDA
GO:0045603 positive regulation of endothelial cell differentiationIDA
GO:0045606 positive regulation of epidermal cell differentiationISS
GO:0045606 positive regulation of epidermal cell differentiationISO
GO:0045662 negative regulation of myoblast differentiationISO
GO:0045666 positive regulation of neuron differentiationISO
GO:0045666 positive regulation of neuron differentiationIDA
GO:0045669 positive regulation of osteoblast differentiationISO
GO:0045669 positive regulation of osteoblast differentiationISS
GO:0045778 positive regulation of ossificationISO
GO:0045778 positive regulation of ossificationIDA
GO:0045786 negative regulation of cell cycleISS
GO:0045786 negative regulation of cell cycleISO
GO:0045839 negative regulation of mitotic nuclear divisionISS
GO:0045839 negative regulation of mitotic nuclear divisionISO
GO:0045843 negative regulation of striated muscle tissue developmentISO
GO:0045892 negative regulation of transcription, DNA-templatedISS
GO:0045892 negative regulation of transcription, DNA-templatedISO
GO:0045893 positive regulation of transcription, DNA-templatedISS
GO:0045893 positive regulation of transcription, DNA-templatedISO
GO:0045893 positive regulation of transcription, DNA-templatedTAS
GO:0045944 positive regulation of transcription by RNA polymerase IIISO
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIMP
GO:0048286 lung alveolus developmentISO
GO:0048333 mesodermal cell differentiationIDA
GO:0048392 intermediate mesodermal cell differentiationISS
GO:0048392 intermediate mesodermal cell differentiationISO
GO:0048593 camera-type eye morphogenesisIMP
GO:0048598 embryonic morphogenesisIMP
GO:0048646 anatomical structure formation involved in morphogenesisIGI
GO:0048660 regulation of smooth muscle cell proliferationIDA
GO:0048661 positive regulation of smooth muscle cell proliferationISS
GO:0048661 positive regulation of smooth muscle cell proliferationISO
GO:0048663 neuron fate commitmentIDA
GO:0048663 neuron fate commitmentIMP
GO:0048701 embryonic cranial skeleton morphogenesisIMP
GO:0048704 embryonic skeletal system morphogenesisIMP
GO:0048706 embryonic skeletal system developmentIMP
GO:0048715 negative regulation of oligodendrocyte differentiationISO
GO:0048745 smooth muscle tissue developmentIMP
GO:0048754 branching morphogenesis of an epithelial tubeISS
GO:0048754 branching morphogenesis of an epithelial tubeISO
GO:0050679 positive regulation of epithelial cell proliferationISS
GO:0050679 positive regulation of epithelial cell proliferationISO
GO:0050680 negative regulation of epithelial cell proliferationIMP
GO:0050918 positive chemotaxisISS
GO:0051145 smooth muscle cell differentiationIDA
GO:0051150 regulation of smooth muscle cell differentiationIDA
GO:0051150 regulation of smooth muscle cell differentiationIGI
GO:0055007 cardiac muscle cell differentiationIGI
GO:0055007 cardiac muscle cell differentiationNAS
GO:0055020 positive regulation of cardiac muscle fiber developmentISS
GO:0055020 positive regulation of cardiac muscle fiber developmentISO
GO:0060113 inner ear receptor cell differentiationIGI
GO:0060197 cloacal septationIEP
GO:0060235 lens induction in camera-type eyeIMP
GO:0060272 embryonic skeletal joint morphogenesisIGI
GO:0060272 embryonic skeletal joint morphogenesisIMP
GO:0060348 bone developmentIDA
GO:0060363 cranial suture morphogenesisIDA
GO:0060391 positive regulation of SMAD protein signal transductionISS
GO:0060391 positive regulation of SMAD protein signal transductionISO
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylationISS
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylationISO
GO:0060395 SMAD protein signal transductionISS
GO:0060395 SMAD protein signal transductionISO
GO:0060395 SMAD protein signal transductionIBA
GO:0060395 SMAD protein signal transductionIDA
GO:0060425 lung morphogenesisISO
GO:0060429 epithelium developmentIDA
GO:0060433 bronchus developmentISO
GO:0060438 trachea developmentISO
GO:0060440 trachea formationIMP
GO:0060441 epithelial tube branching involved in lung morphogenesisISO
GO:0060442 branching involved in prostate gland morphogenesisIMP
GO:0060449 bud elongation involved in lung branchingIDA
GO:0060502 epithelial cell proliferation involved in lung morphogenesisISO
GO:0060503 bud dilation involved in lung branchingISO
GO:0060512 prostate gland morphogenesisIMP
GO:0060548 negative regulation of cell deathISS
GO:0060548 negative regulation of cell deathISO
GO:0060592 mammary gland formationIMP
GO:0060684 epithelial-mesenchymal cell signalingIDA
GO:0060686 negative regulation of prostatic bud formationIMP
GO:0060686 negative regulation of prostatic bud formationIDA
GO:0060687 regulation of branching involved in prostate gland morphogenesisIMP
GO:0060688 regulation of morphogenesis of a branching structureIMP
GO:0060976 coronary vasculature developmentIMP
GO:0061035 regulation of cartilage developmentIDA
GO:0061036 positive regulation of cartilage developmentISO
GO:0061047 positive regulation of branching involved in lung morphogenesisIMP
GO:0061149 BMP signaling pathway involved in ureter morphogenesisIDA
GO:0061151 BMP signaling pathway involved in renal system segmentationIMP
GO:0061155 pulmonary artery endothelial tube morphogenesisISS
GO:0061155 pulmonary artery endothelial tube morphogenesisISO
GO:0061312 BMP signaling pathway involved in heart developmentIMP
GO:0061626 pharyngeal arch artery morphogenesisIMP
GO:0070244 negative regulation of thymocyte apoptotic processISS
GO:0070244 negative regulation of thymocyte apoptotic processISO
GO:0070368 positive regulation of hepatocyte differentiationISO
GO:0070372 regulation of ERK1 and ERK2 cascadeISO
GO:0070374 positive regulation of ERK1 and ERK2 cascadeIDA
GO:0071363 cellular response to growth factor stimulusIDA
GO:0071549 cellular response to dexamethasone stimulusISO
GO:0071773 cellular response to BMP stimulusISO
GO:0071893 BMP signaling pathway involved in nephric duct formationISS
GO:0071893 BMP signaling pathway involved in nephric duct formationISO
GO:0072015 glomerular visceral epithelial cell developmentIEP
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathwayISS
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathwayISO
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathwayISS
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathwayISO
GO:0072104 glomerular capillary formationIMP
GO:0072125 negative regulation of glomerular mesangial cell proliferationISS
GO:0072125 negative regulation of glomerular mesangial cell proliferationISO
GO:0072138 mesenchymal cell proliferation involved in ureteric bud developmentIEP
GO:0072161 mesenchymal cell differentiation involved in kidney developmentIMP
GO:0072192 ureter epithelial cell differentiationIMP
GO:0072193 ureter smooth muscle cell differentiationIMP
GO:0072198 mesenchymal cell proliferation involved in ureter developmentIEP
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter developmentISS
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter developmentISO
GO:0072205 metanephric collecting duct developmentIMP
GO:0090184 positive regulation of kidney developmentISS
GO:0090184 positive regulation of kidney developmentISO
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesisISO
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesisISS
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesisISO
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesisIDA
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesisIGI
GO:0090194 negative regulation of glomerulus developmentISS
GO:0090194 negative regulation of glomerulus developmentISO
GO:1901341 positive regulation of store-operated calcium channel activityISO
GO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesisIMP
GO:1902462 positive regulation of mesenchymal stem cell proliferationISO
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase IIISO
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase IIIGI
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNAISO
GO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesisIGI
GO:2000005 negative regulation of metanephric S-shaped body morphogenesisISS
GO:2000005 negative regulation of metanephric S-shaped body morphogenesisISO
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesisISS
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesisISO
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesisISS
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesisISO
GO:2000353 positive regulation of endothelial cell apoptotic processISO
GO:2001012 mesenchymal cell differentiation involved in renal system developmentIMP
GO:2001237 negative regulation of extrinsic apoptotic signaling pathwayIMP
GO:0001654 eye developmentIGI
GO:0003150 muscular septum morphogenesisIMP
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formationIMP
GO:0003215 cardiac right ventricle morphogenesisIMP
GO:0003277 apoptotic process involved in endocardial cushion morphogenesisIMP
GO:1905072 cardiac jelly developmentIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005576 extracellular regionIDA
GO:0005615 extracellular spaceISO
GO:0005615 extracellular spaceIDA
GO:0005615 extracellular spaceIBA
GO:0005623 cellIEA
GO:0005737 cytoplasmISO
GO:0031982 vesicleISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1474244 Extracellular matrix organizationIEA
R-MMU-1566948 Elastic fibre formationIEA
R-MMU-2129379 Molecules associated with elastic fibresIEA
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)IEA
R-MMU-392499 Metabolism of proteinsIEA
R-MMU-597592 Post-translational protein modificationIEA
R-MMU-8957275 Post-translational protein phosphorylationIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0891 Chondrogenesis
KW-0165 Cleavage on pair of basic residues
KW-0202 Cytokine
KW-0217 Developmental protein
KW-0221 Differentiation
KW-1015 Disulfide bond
KW-0272 Extracellular matrix
KW-0325 Glycoprotein
KW-0339 Growth factor
KW-0892 Osteogenesis
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide

Protein-protein interaction

Protein-miRNA interaction