CleftGeneDB-Search

Gene: Bmp4

Basic information

Tag	Content
Uniprot ID	P21275
Entrez ID	12159
Genbank protein ID	CAA40179.1; AAC37698.1; AAH52846.1; AAB28021.1; AAH34053.1; AAH13459.1; BAA03555.1;
Genbank nucleotide ID	XM_006518467.3; XM_011244935.2; XM_006518468.3; XM_011244934.2; NM_001316360.1; NM_007554.3;
Ensembl protein ID	ENSMUSP00000098242; ENSMUSP00000073720;
Ensembl nucleotide ID	ENSMUSG00000021835
Gene name	Bone morphogenetic protein 4
Gene symbol	Bmp4
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO,CLO
Developmental stage	E11.5, E12.5, E13.5, E14.5, E15.5, E16.5
Data sources	Manually collected
Reference	30235284; 15716346; 27933520; 24785830; 22219353;
Functional description	Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
Sequence	MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 60 LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS 120 FHHEEHLENI PGTSESSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN 180 IYEVMKPPAE MVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 240 HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 300 SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 360 VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR 408

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Protein disorder visualization from D2P2 is currently unavailable.

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	BMP4	407216	Q2KJH1			Bos taurus	Prediction	More>>
1:1 ortholog	BMP4	490695	F1PDL1			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	BMP4	100860789	A0A2Z4FRB3			Capra hircus	Prediction	More>>
1:1 ortholog	BMP4	100034048	F6QG82			Equus caballus	Prediction	More>>
1:1 ortholog	BMP4	652	P12644	CPO,CL/P		Homo sapiens	Publication	More>>
1:1 ortholog	Bmp4	12159	P21275	CPO,CLO	E11.5, E12.5, E13.5, E14.5, E15.5, E16.5	Mus musculus	Publication	More>>
1:1 ortholog	BMP4	100113425	A7LJT9			Sus scrofa	Prediction	More>>
1:1 ortholog	BMP4	100009569	G1T0L5			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Bmp4	25296	Q6AYU9			Rattus norvegicus	Prediction	More>>
1:1 ortholog	bmp4		F1QAD6			Danio rerio	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
BMP4	rs17563; c.538T>C	Polymerase chain reaction-restriction fragment length polymorphism	26424979
BMP4	rs17563 C allele	PCR-RFLP	23227324
BMP4	rs17563	Real-time polymerase chain reaction using the Taqman assay method	23237431
BMP4	rs10130587	Genotyping	22514733
BMP4	rs2738265	Genotyping	22514733
BMP4	rs2761887	Genotyping	22514733
BMP4	rs762642	Genotyping	22514733
BMP4	c.-5514G > A	PCR	22182590
BMP4	c.-5365C > T	PCR	22182590
BMP4	c.-5049C > T	PCR	22182590
BMP4	rs2855530	PCR	22182590
BMP4	rs17563	Genotyping	19914800
BMP4	rs762642	TDT	19839778
BMP4	rs2855532	TDT	19839778
BMP4	rs1957860	TDT	19839778
BMP4	c.538T>C	PCR; RFLP	18771417
BMP4	rs17563	GWAS	3221112
BMP4	rs762642T>G	Direct sequencing; PCR	29860186
BMP4	rs17563T>C	Direct sequencing; PCR	29860186
BMP4	rs10130587C>G	Direct sequencing; PCR	29860186
BMP4	rs35107139T>G	Direct sequencing; PCR	29860186
BMP4	c.455T>C; p.V152A	WES and Sanger sequencing	26449438

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005125	cytokine activity	ISO
GO:0005125	cytokine activity	IBA
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	ISO
GO:0008201	heparin binding	IDA
GO:0039706	co-receptor binding	ISO
GO:0042056	chemoattractant activity	ISS
GO:0042056	chemoattractant activity	ISO
GO:0042802	identical protein binding	ISO
GO:0070700	BMP receptor binding	ISS
GO:0070700	BMP receptor binding	IBA
GO:0070700	BMP receptor binding	ISO

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
GO:0000122	negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	negative regulation of transcription by RNA polymerase II	ISO
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
GO:0000186	activation of MAPKK activity	ISS
GO:0000186	activation of MAPKK activity	ISO
GO:0001501	skeletal system development	IDA
GO:0001501	skeletal system development	IMP
GO:0001525	angiogenesis	IMP
GO:0001541	ovarian follicle development	ISO
GO:0001568	blood vessel development	IDA
GO:0001649	osteoblast differentiation	ISS
GO:0001649	osteoblast differentiation	ISO
GO:0001649	osteoblast differentiation	IDA
GO:0001656	metanephros development	IDA
GO:0001656	metanephros development	IMP
GO:0001657	ureteric bud development	ISO
GO:0001657	ureteric bud development	IDA
GO:0001657	ureteric bud development	IMP
GO:0001658	branching involved in ureteric bud morphogenesis	ISS
GO:0001658	branching involved in ureteric bud morphogenesis	ISO
GO:0001658	branching involved in ureteric bud morphogenesis	IGI
GO:0001707	mesoderm formation	IDA
GO:0001759	organ induction	IMP
GO:0001822	kidney development	ISS
GO:0001822	kidney development	ISO
GO:0001822	kidney development	IGI
GO:0001822	kidney development	IMP
GO:0001823	mesonephros development	ISS
GO:0001843	neural tube closure	IDA
GO:0001934	positive regulation of protein phosphorylation	ISO
GO:0001934	positive regulation of protein phosphorylation	IMP
GO:0001936	regulation of endothelial cell proliferation	TAS
GO:0001938	positive regulation of endothelial cell proliferation	ISS
GO:0001938	positive regulation of endothelial cell proliferation	ISO
GO:0001938	positive regulation of endothelial cell proliferation	IDA
GO:0001944	vasculature development	IMP
GO:0001958	endochondral ossification	IMP
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO
GO:0002062	chondrocyte differentiation	IMP
GO:0002244	hematopoietic progenitor cell differentiation	ISS
GO:0002244	hematopoietic progenitor cell differentiation	ISO
GO:0002244	hematopoietic progenitor cell differentiation	IDA
GO:0002320	lymphoid progenitor cell differentiation	ISS
GO:0002320	lymphoid progenitor cell differentiation	ISO
GO:0003014	renal system process	IMP
GO:0003130	BMP signaling pathway involved in heart induction	ISS
GO:0003130	BMP signaling pathway involved in heart induction	ISO
GO:0003139	secondary heart field specification	ISS
GO:0003139	secondary heart field specification	ISO
GO:0003148	outflow tract septum morphogenesis	IMP
GO:0003149	membranous septum morphogenesis	IMP
GO:0003151	outflow tract morphogenesis	IGI
GO:0003180	aortic valve morphogenesis	IMP
GO:0003184	pulmonary valve morphogenesis	IMP
GO:0003197	endocardial cushion development	IMP
GO:0003323	type B pancreatic cell development	ISS
GO:0003323	type B pancreatic cell development	ISO
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	ISS
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO
GO:0007182	common-partner SMAD protein phosphorylation	ISS
GO:0007182	common-partner SMAD protein phosphorylation	ISO
GO:0007224	smoothened signaling pathway	IEA
GO:0007281	germ cell development	IMP
GO:0007492	endoderm development	IDA
GO:0007500	mesodermal cell fate determination	IMP
GO:0007507	heart development	IMP
GO:0008284	positive regulation of cell population proliferation	ISS
GO:0008284	positive regulation of cell population proliferation	ISO
GO:0008284	positive regulation of cell population proliferation	IMP
GO:0008285	negative regulation of cell population proliferation	IGI
GO:0008285	negative regulation of cell population proliferation	ISO
GO:0009791	post-embryonic development	ISO
GO:0009791	post-embryonic development	IMP
GO:0009888	tissue development	IGI
GO:0009948	anterior/posterior axis specification	IGI
GO:0010159	specification of animal organ position	IMP
GO:0010453	regulation of cell fate commitment	ISS
GO:0010453	regulation of cell fate commitment	ISO
GO:0010468	regulation of gene expression	IDA
GO:0010468	regulation of gene expression	IMP
GO:0010524	positive regulation of calcium ion transport into cytosol	ISO
GO:0010595	positive regulation of endothelial cell migration	ISS
GO:0010595	positive regulation of endothelial cell migration	ISO
GO:0010595	positive regulation of endothelial cell migration	TAS
GO:0010628	positive regulation of gene expression	ISO
GO:0010628	positive regulation of gene expression	IMP
GO:0010628	positive regulation of gene expression	IDA
GO:0010629	negative regulation of gene expression	ISO
GO:0010629	negative regulation of gene expression	IDA
GO:0010718	positive regulation of epithelial to mesenchymal transition	IGI
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISS
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
GO:0010942	positive regulation of cell death	ISO
GO:0010976	positive regulation of neuron projection development	ISO
GO:0021537	telencephalon development	ISO
GO:0021904	dorsal/ventral neural tube patterning	IDA
GO:0021978	telencephalon regionalization	IGI
GO:0021978	telencephalon regionalization	IDA
GO:0021983	pituitary gland development	IMP
GO:0030218	erythrocyte differentiation	IDA
GO:0030224	monocyte differentiation	ISO
GO:0030225	macrophage differentiation	ISO
GO:0030324	lung development	IMP
GO:0030326	embryonic limb morphogenesis	IGI
GO:0030326	embryonic limb morphogenesis	IMP
GO:0030335	positive regulation of cell migration	IMP
GO:0030501	positive regulation of bone mineralization	ISO
GO:0030501	positive regulation of bone mineralization	ISS
GO:0030509	BMP signaling pathway	ISS
GO:0030509	BMP signaling pathway	ISO
GO:0030509	BMP signaling pathway	IDA
GO:0030509	BMP signaling pathway	IGI
GO:0030509	BMP signaling pathway	IBA
GO:0030513	positive regulation of BMP signaling pathway	IDA
GO:0030900	forebrain development	IGI
GO:0030900	forebrain development	IMP
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS
GO:0032092	positive regulation of protein binding	ISO
GO:0032331	negative regulation of chondrocyte differentiation	IDA
GO:0032967	positive regulation of collagen biosynthetic process	ISS
GO:0032967	positive regulation of collagen biosynthetic process	ISO
GO:0033085	negative regulation of T cell differentiation in thymus	ISO
GO:0033088	negative regulation of immature T cell proliferation in thymus	ISS
GO:0033088	negative regulation of immature T cell proliferation in thymus	ISO
GO:0034504	protein localization to nucleus	ISS
GO:0034504	protein localization to nucleus	ISO
GO:0034599	cellular response to oxidative stress	ISO
GO:0035116	embryonic hindlimb morphogenesis	IGI
GO:0035990	tendon cell differentiation	IMP
GO:0035993	deltoid tuberosity development	IMP
GO:0042306	regulation of protein import into nucleus	ISO
GO:0042326	negative regulation of phosphorylation	ISS
GO:0042326	negative regulation of phosphorylation	ISO
GO:0042475	odontogenesis of dentin-containing tooth	IDA
GO:0042475	odontogenesis of dentin-containing tooth	IGI
GO:0042476	odontogenesis	ISS
GO:0042476	odontogenesis	ISO
GO:0042487	regulation of odontogenesis of dentin-containing tooth	IGI
GO:0042733	embryonic digit morphogenesis	IGI
GO:0043010	camera-type eye development	IGI
GO:0043010	camera-type eye development	IMP
GO:0043065	positive regulation of apoptotic process	ISS
GO:0043065	positive regulation of apoptotic process	ISO
GO:0043066	negative regulation of apoptotic process	ISS
GO:0043066	negative regulation of apoptotic process	ISO
GO:0043066	negative regulation of apoptotic process	IMP
GO:0043066	negative regulation of apoptotic process	IBA
GO:0043401	steroid hormone mediated signaling pathway	ISS
GO:0043401	steroid hormone mediated signaling pathway	ISO
GO:0043407	negative regulation of MAP kinase activity	ISS
GO:0043407	negative regulation of MAP kinase activity	ISO
GO:0045165	cell fate commitment	IDA
GO:0045595	regulation of cell differentiation	ISO
GO:0045595	regulation of cell differentiation	IGI
GO:0045597	positive regulation of cell differentiation	IDA
GO:0045603	positive regulation of endothelial cell differentiation	IDA
GO:0045606	positive regulation of epidermal cell differentiation	ISS
GO:0045606	positive regulation of epidermal cell differentiation	ISO
GO:0045662	negative regulation of myoblast differentiation	ISO
GO:0045666	positive regulation of neuron differentiation	ISO
GO:0045666	positive regulation of neuron differentiation	IDA
GO:0045669	positive regulation of osteoblast differentiation	ISO
GO:0045669	positive regulation of osteoblast differentiation	ISS
GO:0045778	positive regulation of ossification	ISO
GO:0045778	positive regulation of ossification	IDA
GO:0045786	negative regulation of cell cycle	ISS
GO:0045786	negative regulation of cell cycle	ISO
GO:0045839	negative regulation of mitotic nuclear division	ISS
GO:0045839	negative regulation of mitotic nuclear division	ISO
GO:0045843	negative regulation of striated muscle tissue development	ISO
GO:0045892	negative regulation of transcription, DNA-templated	ISS
GO:0045892	negative regulation of transcription, DNA-templated	ISO
GO:0045893	positive regulation of transcription, DNA-templated	ISS
GO:0045893	positive regulation of transcription, DNA-templated	ISO
GO:0045893	positive regulation of transcription, DNA-templated	TAS
GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
GO:0048286	lung alveolus development	ISO
GO:0048333	mesodermal cell differentiation	IDA
GO:0048392	intermediate mesodermal cell differentiation	ISS
GO:0048392	intermediate mesodermal cell differentiation	ISO
GO:0048593	camera-type eye morphogenesis	IMP
GO:0048598	embryonic morphogenesis	IMP
GO:0048646	anatomical structure formation involved in morphogenesis	IGI
GO:0048660	regulation of smooth muscle cell proliferation	IDA
GO:0048661	positive regulation of smooth muscle cell proliferation	ISS
GO:0048661	positive regulation of smooth muscle cell proliferation	ISO
GO:0048663	neuron fate commitment	IDA
GO:0048663	neuron fate commitment	IMP
GO:0048701	embryonic cranial skeleton morphogenesis	IMP
GO:0048704	embryonic skeletal system morphogenesis	IMP
GO:0048706	embryonic skeletal system development	IMP
GO:0048715	negative regulation of oligodendrocyte differentiation	ISO
GO:0048745	smooth muscle tissue development	IMP
GO:0048754	branching morphogenesis of an epithelial tube	ISS
GO:0048754	branching morphogenesis of an epithelial tube	ISO
GO:0050679	positive regulation of epithelial cell proliferation	ISS
GO:0050679	positive regulation of epithelial cell proliferation	ISO
GO:0050680	negative regulation of epithelial cell proliferation	IMP
GO:0050918	positive chemotaxis	ISS
GO:0051145	smooth muscle cell differentiation	IDA
GO:0051150	regulation of smooth muscle cell differentiation	IDA
GO:0051150	regulation of smooth muscle cell differentiation	IGI
GO:0055007	cardiac muscle cell differentiation	IGI
GO:0055007	cardiac muscle cell differentiation	NAS
GO:0055020	positive regulation of cardiac muscle fiber development	ISS
GO:0055020	positive regulation of cardiac muscle fiber development	ISO
GO:0060113	inner ear receptor cell differentiation	IGI
GO:0060197	cloacal septation	IEP
GO:0060235	lens induction in camera-type eye	IMP
GO:0060272	embryonic skeletal joint morphogenesis	IGI
GO:0060272	embryonic skeletal joint morphogenesis	IMP
GO:0060348	bone development	IDA
GO:0060363	cranial suture morphogenesis	IDA
GO:0060391	positive regulation of SMAD protein signal transduction	ISS
GO:0060391	positive regulation of SMAD protein signal transduction	ISO
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	ISS
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	ISO
GO:0060395	SMAD protein signal transduction	ISS
GO:0060395	SMAD protein signal transduction	ISO
GO:0060395	SMAD protein signal transduction	IBA
GO:0060395	SMAD protein signal transduction	IDA
GO:0060425	lung morphogenesis	ISO
GO:0060429	epithelium development	IDA
GO:0060433	bronchus development	ISO
GO:0060438	trachea development	ISO
GO:0060440	trachea formation	IMP
GO:0060441	epithelial tube branching involved in lung morphogenesis	ISO
GO:0060442	branching involved in prostate gland morphogenesis	IMP
GO:0060449	bud elongation involved in lung branching	IDA
GO:0060502	epithelial cell proliferation involved in lung morphogenesis	ISO
GO:0060503	bud dilation involved in lung branching	ISO
GO:0060512	prostate gland morphogenesis	IMP
GO:0060548	negative regulation of cell death	ISS
GO:0060548	negative regulation of cell death	ISO
GO:0060592	mammary gland formation	IMP
GO:0060684	epithelial-mesenchymal cell signaling	IDA
GO:0060686	negative regulation of prostatic bud formation	IMP
GO:0060686	negative regulation of prostatic bud formation	IDA
GO:0060687	regulation of branching involved in prostate gland morphogenesis	IMP
GO:0060688	regulation of morphogenesis of a branching structure	IMP
GO:0060976	coronary vasculature development	IMP
GO:0061035	regulation of cartilage development	IDA
GO:0061036	positive regulation of cartilage development	ISO
GO:0061047	positive regulation of branching involved in lung morphogenesis	IMP
GO:0061149	BMP signaling pathway involved in ureter morphogenesis	IDA
GO:0061151	BMP signaling pathway involved in renal system segmentation	IMP
GO:0061155	pulmonary artery endothelial tube morphogenesis	ISS
GO:0061155	pulmonary artery endothelial tube morphogenesis	ISO
GO:0061312	BMP signaling pathway involved in heart development	IMP
GO:0061626	pharyngeal arch artery morphogenesis	IMP
GO:0070244	negative regulation of thymocyte apoptotic process	ISS
GO:0070244	negative regulation of thymocyte apoptotic process	ISO
GO:0070368	positive regulation of hepatocyte differentiation	ISO
GO:0070372	regulation of ERK1 and ERK2 cascade	ISO
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA
GO:0071363	cellular response to growth factor stimulus	IDA
GO:0071549	cellular response to dexamethasone stimulus	ISO
GO:0071773	cellular response to BMP stimulus	ISO
GO:0071893	BMP signaling pathway involved in nephric duct formation	ISS
GO:0071893	BMP signaling pathway involved in nephric duct formation	ISO
GO:0072015	glomerular visceral epithelial cell development	IEP
GO:0072097	negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway	ISS
GO:0072097	negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway	ISO
GO:0072101	specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway	ISS
GO:0072101	specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway	ISO
GO:0072104	glomerular capillary formation	IMP
GO:0072125	negative regulation of glomerular mesangial cell proliferation	ISS
GO:0072125	negative regulation of glomerular mesangial cell proliferation	ISO
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development	IEP
GO:0072161	mesenchymal cell differentiation involved in kidney development	IMP
GO:0072192	ureter epithelial cell differentiation	IMP
GO:0072193	ureter smooth muscle cell differentiation	IMP
GO:0072198	mesenchymal cell proliferation involved in ureter development	IEP
GO:0072200	negative regulation of mesenchymal cell proliferation involved in ureter development	ISS
GO:0072200	negative regulation of mesenchymal cell proliferation involved in ureter development	ISO
GO:0072205	metanephric collecting duct development	IMP
GO:0090184	positive regulation of kidney development	ISS
GO:0090184	positive regulation of kidney development	ISO
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	ISO
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	ISS
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	ISO
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	IDA
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	IGI
GO:0090194	negative regulation of glomerulus development	ISS
GO:0090194	negative regulation of glomerulus development	ISO
GO:1901341	positive regulation of store-operated calcium channel activity	ISO
GO:1901964	positive regulation of cell proliferation involved in outflow tract morphogenesis	IMP
GO:1902462	positive regulation of mesenchymal stem cell proliferation	ISO
GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	ISO
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	IGI
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	ISO
GO:1905312	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IGI
GO:2000005	negative regulation of metanephric S-shaped body morphogenesis	ISS
GO:2000005	negative regulation of metanephric S-shaped body morphogenesis	ISO
GO:2000007	negative regulation of metanephric comma-shaped body morphogenesis	ISS
GO:2000007	negative regulation of metanephric comma-shaped body morphogenesis	ISO
GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	ISS
GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	ISO
GO:2000353	positive regulation of endothelial cell apoptotic process	ISO
GO:2001012	mesenchymal cell differentiation involved in renal system development	IMP
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IMP
GO:0001654	eye development	IGI
GO:0003150	muscular septum morphogenesis	IMP
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IMP
GO:0003215	cardiac right ventricle morphogenesis	IMP
GO:0003277	apoptotic process involved in endocardial cushion morphogenesis	IMP
GO:1905072	cardiac jelly development	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	IDA
GO:0005615	extracellular space	ISO
GO:0005615	extracellular space	IDA
GO:0005615	extracellular space	IBA
GO:0005623	cell	IEA
GO:0005737	cytoplasm	ISO
GO:0031982	vesicle	ISO

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-1474244	Extracellular matrix organization	IEA
R-MMU-1566948	Elastic fibre formation	IEA
R-MMU-2129379	Molecules associated with elastic fibres	IEA
R-MMU-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	IEA
R-MMU-392499	Metabolism of proteins	IEA
R-MMU-597592	Post-translational protein modification	IEA
R-MMU-8957275	Post-translational protein phosphorylation	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0891	Chondrogenesis
KW-0165	Cleavage on pair of basic residues
KW-0202	Cytokine
KW-0217	Developmental protein
KW-0221	Differentiation
KW-1015	Disulfide bond
KW-0272	Extracellular matrix
KW-0325	Glycoprotein
KW-0339	Growth factor
KW-0892	Osteogenesis
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal

Interpro

InterPro ID	InterPro Term
IPR029034	Cystine-knot_cytokine
IPR001839	TGF-b_C
IPR001111	TGF-b_propeptide
IPR015615	TGF-beta-rel
IPR017948	TGFb_CS

PROSITE

PROSITE ID	PROSITE Term
PS00250	TGF_BETA_1
PS51362	TGF_BETA_2

Pfam

Pfam ID	Pfam Term
PF00019	TGF_beta
PF00688	TGFb_propeptide