Gene: BMP4

Basic information

Tag Content
Uniprot ID G1T0L5
Entrez ID 100009569
Genbank protein ID
Genbank nucleotide ID NM_001195723.1
Ensembl protein ID ENSOCUP00000009545
Ensembl nucleotide ID ENSOCUG00000011097
Gene name Bone morphogenetic protein 4
Gene symbol BMP4
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 60
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQM PSGGLEYPER PASRANTVRS 120
FHHEEHLENI PGTSENSAFR FLFNLSSIPE NEAISSAELR LFREQVDQGP DWERGFHRIN 180
IYEVMKPPAE AVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNHGLAVEVT 240
HLHHTRTHQG QHVRVSRSLP QGSGDWAQLR PLLVTFGHDG RGHALTRRRR AKRSPKHHPQ 300
RARKKNKNCR RHALYVDFSD VGWNDWIVAP PGYQAFYCHG DCPFPLADHL NSTNHAIVQT 360
LVNSVNSSIP KACCVPTELS AISMLYLDEY DKVVLKNYQE MVVEGCGCR 409

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBMP4407216Q2KJH1Bos taurusPredictionMore>>
1:1 orthologBMP4490695F1PDL1Canis lupus familiarisPredictionMore>>
1:1 orthologBMP4100860789A0A2Z4FRB3Capra hircusPredictionMore>>
1:1 orthologBMP4100034048F6QG82Equus caballusPredictionMore>>
1:1 orthologBMP4652P12644CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologBmp412159P21275CPO,CLOE11.5, E12.5, E13.5, E14.5, E15.5, E16.5Mus musculusPublicationMore>>
1:1 orthologBMP4100113425A7LJT9Sus scrofaPredictionMore>>
1:1 orthologBMP4100009569G1T0L5Oryctolagus cuniculusPredictionMore>>
1:1 orthologBmp425296Q6AYU9Rattus norvegicusPredictionMore>>
1:1 orthologbmp4F1QAD6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0070700 BMP receptor binding
GO:0042056 chemoattractant activity
GO:0039706 co-receptor binding
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0000186 activation of MAPKK activity
GO:0009948 anterior/posterior axis specification
GO:0003180 aortic valve morphogenesis
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0061312 BMP signaling pathway involved in heart development
GO:0003130 BMP signaling pathway involved in heart induction
GO:0071893 BMP signaling pathway involved in nephric duct formation
GO:0061151 BMP signaling pathway involved in renal system segmentation
GO:0061149 BMP signaling pathway involved in ureter morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0060433 bronchus development
GO:0060503 bud dilation involved in lung branching
GO:0060449 bud elongation involved in lung branching
GO:0055007 cardiac muscle cell differentiation
GO:0002062 chondrocyte differentiation
GO:0060197 cloacal septation
GO:0007182 common-partner SMAD protein phosphorylation
GO:0060976 coronary vasculature development
GO:0060363 cranial suture morphogenesis
GO:0035993 deltoid tuberosity development
GO:0021904 dorsal/ventral neural tube patterning
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0060272 embryonic skeletal joint morphogenesis
GO:0003197 endocardial cushion development
GO:0001958 endochondral ossification
GO:0007492 endoderm development
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060684 epithelial-mesenchymal cell signaling
GO:0030218 erythrocyte differentiation
GO:0007281 germ cell development
GO:0072104 glomerular capillary formation
GO:0072015 glomerular visceral epithelial cell development
GO:0060113 inner ear receptor cell differentiation
GO:0048392 intermediate mesodermal cell differentiation
GO:0060235 lens induction in camera-type eye
GO:0048286 lung alveolus development
GO:0002320 lymphoid progenitor cell differentiation
GO:0030225 macrophage differentiation
GO:0060592 mammary gland formation
GO:0003149 membranous septum morphogenesis
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0072198 mesenchymal cell proliferation involved in ureter development
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007500 mesodermal cell fate determination
GO:0072205 metanephric collecting duct development
GO:0030224 monocyte differentiation
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis
GO:0032331 negative regulation of chondrocyte differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0043407 negative regulation of MAP kinase activity
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesis
GO:2000005 negative regulation of metanephric S-shaped body morphogenesis
GO:0045839 negative regulation of mitotic nuclear division
GO:0045662 negative regulation of myoblast differentiation
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:0060686 negative regulation of prostatic bud formation
GO:0045843 negative regulation of striated muscle tissue development
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0001843 neural tube closure
GO:0048663 neuron fate commitment
GO:0042475 odontogenesis of dentin-containing tooth
GO:0001649 osteoblast differentiation
GO:0003148 outflow tract septum morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0021983 pituitary gland development
GO:0043065 positive regulation of apoptotic process
GO:0030513 positive regulation of BMP signaling pathway
GO:0030501 positive regulation of bone mineralization
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0055020 positive regulation of cardiac muscle fiber development
GO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0061036 positive regulation of cartilage development
GO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis
GO:0032967 positive regulation of collagen biosynthetic process
GO:0045603 positive regulation of endothelial cell differentiation
GO:0010595 positive regulation of endothelial cell migration
GO:0001938 positive regulation of endothelial cell proliferation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090184 positive regulation of kidney development
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:0032092 positive regulation of protein binding
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0009791 post-embryonic development
GO:0034504 protein localization to nucleus
GO:0061155 pulmonary artery endothelial tube morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0010453 regulation of cell fate commitment
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042306 regulation of protein import into nucleus
GO:0051150 regulation of smooth muscle cell differentiation
GO:0003014 renal system process
GO:0003139 secondary heart field specification
GO:0060395 SMAD protein signal transduction
GO:0007224 smoothened signaling pathway
GO:0010159 specification of animal organ position
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0043401 steroid hormone mediated signaling pathway
GO:0021978 telencephalon regionalization
GO:0035990 tendon cell differentiation
GO:0060440 trachea formation
GO:0003323 type B pancreatic cell development
GO:0072192 ureter epithelial cell differentiation
GO:0072193 ureter smooth muscle cell differentiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide