Gene: tcn2

Basic information

Tag Content
Uniprot ID F2Z4S3
Entrez ID 407646
Genbank protein ID
Genbank nucleotide ID NM_001123231.2
Ensembl protein ID ENSDARP00000053000
Ensembl nucleotide ID ENSDARG00000036481
Gene name Transcobalamin II
Gene symbol tcn2
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MITLLIVSAL LALAAGKPCA SDHETLLQSL NKQLLRSVDT QDNLPNPSVH IALRLSTQHN 60
LDKENQYLNR LKKEFHEDIE KSLRNGELVV GRLALYILAL RSSCHDLSLH LNHNEKNEFL 120
LTHLKKEMEE EKQNIAFSHR PKTNYYQYSL GILALCVSGV RVSTHVSHKL IHAVEHGQIK 180
HGESLCIDSH AMAGMALQCL KNEGISVKDE AELDKALATI KQKLVDSKRA DGHMGNEFST 240
GLAVQALLAM GVEMEECGTA IEALRGDIRK GTYHNPMAAS QVLPALYQQS YLHLKSKECR 300
SEDDTLTADV ESASEVLPSL GQVAVQVEVI KSNGEASVFP INVPKGSSLF EALNLLQDKQ 360
TGFTFKTEDS LWGAFLSVLN DEQARQTDRR YWHVSSDGTS LTQGIKDYKI DSAQRITIKN 420
TGY 423

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTCN2281518Q9XSC9Bos taurusPredictionMore>>
1:1 orthologTCN2486355E2RFH1Canis lupus familiarisPredictionMore>>
1:1 orthologTCN2102190723A0A452DSJ0Capra hircusPredictionMore>>
1:1 orthologTCN2100063639F6U5V3Equus caballusPredictionMore>>
1:1 orthologTCN26948P20062Homo sapiensPublicationMore>>
1:1 orthologTcn221452O88968Mus musculusPredictionMore>>
1:1 orthologTCN2470178H2QLH6Pan troglodytesPredictionMore>>
1:1 orthologTCN2100152846F1RPE4Sus scrofaPredictionMore>>
1:1 orthologTcn264365G3V6K1Rattus norvegicusPredictionMore>>
1:1 orthologtcn2407646F2Z4S3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0031419 cobalamin binding
GO:0015889 cobalamin transport
GO:0006824 cobalt ion transport

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0170 Cobalt
KW-0171 Cobalt transport
KW-0406 Ion transport
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR002157 Cbl-bd_prot
IPR027954 DUF4430

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01122 Cobalamin_bind
PF14478 DUF4430