Gene: TCN2

Basic information

Tag Content
Uniprot ID Q9XSC9; Q0V8P0; Q1RMV8; Q58CR7; Q58DL8; Q9TR25;
Entrez ID 281518
Genbank protein ID AAX46746.1; AAD23829.1; AAX46506.1; AAX46426.1; AAX46727.1; ABG67017.1; ABG81438.1; AAI14679.1;
Genbank nucleotide ID NM_174195.3
Ensembl protein ID ENSBTAP00000029446
Ensembl nucleotide ID ENSBTAG00000002770
Gene name Transcobalamin-2
Gene symbol TCN2
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Sequence
MGHLGALLFL LGGLGALANI CEITEVDSTL VERLGQRLLP WMDRLSQEQL NPSIYVGLRL 60
SSLQAGAKEA HYLHSLKLSY QQSLLRPASN KDDNDSEAKP SMGQLALYLL ALRANCEFIG 120
GRKGDRLVSQ LKRFLEDEKR AIGHNHQGHP RTSYYQYSLG ILALCVHQKR VHDSVVGKLL 180
YAVEHKPHLL QDHVSVDTMA MAGMAFSCLE LSNLNPKQRN RINLALKRVQ EKILKAQTPE 240
GYFGNVYSTP LALQLLMGSL RPSVELGTAC LKAKAALQAS LQHKTFQNPL MISQLLPVLN 300
QKSYVDLISP DCQAPRALLE PALETPPQAK VPKFIDVLLK VSGISPSYRH SVSVPAGSSL 360
EDILKNAQEH GRFRFRTQAS LSGPFLTSVL GRKAGEREFW QVLRDPDTPL QQGIADYRPK 420
DGETIELRLV GW 432

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTCN2281518Q9XSC9Bos taurusPredictionMore>>
1:1 orthologTCN2486355E2RFH1Canis lupus familiarisPredictionMore>>
1:1 orthologTCN2102190723A0A452DSJ0Capra hircusPredictionMore>>
1:1 orthologTCN2100063639F6U5V3Equus caballusPredictionMore>>
1:1 orthologTCN26948P20062Homo sapiensPublicationMore>>
1:1 orthologTcn221452O88968Mus musculusPredictionMore>>
1:1 orthologTCN2470178H2QLH6Pan troglodytesPredictionMore>>
1:1 orthologTCN2100152846F1RPE4Sus scrofaPredictionMore>>
1:1 orthologTcn264365G3V6K1Rattus norvegicusPredictionMore>>
1:1 orthologtcn2407646F2Z4S3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
GO:0015889 cobalamin transport
GO:0006824 cobalt ion transport

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0170 Cobalt
KW-0171 Cobalt transport
KW-0903 Direct protein sequencing
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-0406 Ion transport
KW-0479 Metal-binding
KW-0621 Polymorphism
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR002157 Cbl-bd_prot

PROSITE

PROSITE ID PROSITE Term
PS00468 COBALAMIN_BINDING

Pfam

Pfam ID Pfam Term
PF01122 Cobalamin_bind