| Tag | Content |
|---|---|
| Uniprot ID | F7CND4 |
| Entrez ID | 100052655 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_001498109.3 |
| Ensembl protein ID | ENSECAP00000012063 |
| Ensembl nucleotide ID | ENSECAG00000014361 |
| Gene name | Fibroblast growth factor |
| Gene symbol | FGF10 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SVSVTCQALG QDMVSPEATN SSSSSSSSSS 60 SSSSFSSPSS AGRHVRSYNH LQGDVRWRKL FSFTKYFLKI EKNGKVSGTK KENCPYSILE 120 ITSVEIGVVA VKAINSNYYL AMNKKGKLYG SKEFNNDCKL KERIEENGYN TYASFNWQHN 180 GRQMYVALNG KGAPRRGQKT RRKNTSAHFL PMVVHS 216 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Protein disorder visualization from D2P2 is currently unavailable.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF10 | 612454 | J9NVD5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FGF10 | 102174339 | A0A142I1Y0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGF10 | 100052655 | F7CND4 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | FGF10 | 2255 | O15520 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Fgf10 | 14165 | O35565 | CPO | E11.5, E11.75, E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGF10 | 471553 | A0A2I3T2G6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FGF10 | F1SMG2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FGF10 | 100342802 | G1SVA6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgf10 | 25443 | P70492 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgf10b | A0A0R4ITI2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0009986 | cell surface |
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0042056 | chemoattractant activity |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0005111 | type 2 fibroblast growth factor receptor binding |
| GO:0031532 | actin cytoskeleton reorganization |
| GO:0000187 | activation of MAPK activity |
| GO:0048514 | blood vessel morphogenesis |
| GO:0001974 | blood vessel remodeling |
| GO:0060667 | branch elongation involved in salivary gland morphogenesis |
| GO:0060436 | bronchiole morphogenesis |
| GO:0060449 | bud elongation involved in lung branching |
| GO:0060447 | bud outgrowth involved in lung branching |
| GO:0007368 | determination of left/right symmetry |
| GO:0031076 | embryonic camera-type eye development |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0030538 | embryonic genitalia morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0060664 | epithelial cell proliferation involved in salivary gland morphogenesis |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0000132 | establishment of mitotic spindle orientation |
| GO:0048807 | female genitalia morphogenesis |
| GO:0060595 | fibroblast growth factor receptor signaling pathway involved in mammary gland specification |
| GO:0031069 | hair follicle morphogenesis |
| GO:0070384 | Harderian gland development |
| GO:0050930 | induction of positive chemotaxis |
| GO:0032808 | lacrimal gland development |
| GO:0060174 | limb bud formation |
| GO:0061115 | lung proximal/distal axis specification |
| GO:0060430 | lung saccule development |
| GO:0048808 | male genitalia morphogenesis |
| GO:0060615 | mammary gland bud formation |
| GO:0060915 | mesenchymal cell differentiation involved in lung development |
| GO:0060496 | mesenchymal-epithelial cell signaling involved in lung development |
| GO:0001823 | mesonephros development |
| GO:0003338 | metanephros morphogenesis |
| GO:0042693 | muscle cell fate commitment |
| GO:0071157 | negative regulation of cell cycle arrest |
| GO:0045596 | negative regulation of cell differentiation |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0001759 | organ induction |
| GO:0030916 | otic vesicle formation |
| GO:0031016 | pancreas development |
| GO:0021983 | pituitary gland development |
| GO:0032781 | positive regulation of ATPase activity |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0045739 | positive regulation of DNA repair |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| GO:0071338 | positive regulation of hair follicle cell proliferation |
| GO:0051549 | positive regulation of keratinocyte migration |
| GO:0010838 | positive regulation of keratinocyte proliferation |
| GO:0050671 | positive regulation of lymphocyte proliferation |
| GO:0045747 | positive regulation of Notch signaling pathway |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0046579 | positive regulation of Ras protein signal transduction |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0050677 | positive regulation of urothelial cell proliferation |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| GO:0070352 | positive regulation of white fat cell proliferation |
| GO:0060513 | prostatic bud formation |
| GO:0034394 | protein localization to cell surface |
| GO:0060019 | radial glial cell differentiation |
| GO:0032925 | regulation of activin receptor signaling pathway |
| GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
| GO:0046877 | regulation of saliva secretion |
| GO:0008589 | regulation of smoothened signaling pathway |
| GO:0061033 | secretion by lung epithelial cell involved in lung growth |
| GO:0060879 | semicircular canal fusion |
| GO:0051145 | smooth muscle cell differentiation |
| GO:0035019 | somatic stem cell population maintenance |
| GO:0048536 | spleen development |
| GO:0060661 | submandibular salivary gland formation |
| GO:0070075 | tear secretion |
| GO:0048538 | thymus development |
| GO:0030878 | thyroid gland development |
| GO:0060510 | type II pneumocyte differentiation |
| GO:0050674 | urothelial cell proliferation |
| GO:0050872 | white fat cell differentiation |
| GO:0042060 | wound healing |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |