CleftGeneDB-Search

Gene: Fgf10

Basic information

Tag	Content
Uniprot ID	O35565; Q543V5;
Entrez ID	14165
Genbank protein ID	BAA22836.1; BAC32287.1; AAH48229.1; AAD00761.1; BAC28816.1; BAE24777.1; BAC39398.1;
Genbank nucleotide ID	NM_008002.4
Ensembl protein ID	ENSMUSP00000022246
Ensembl nucleotide ID	ENSMUSG00000021732
Gene name	Fibroblast growth factor 10
Gene symbol	Fgf10
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO
Developmental stage	E11.5, E11.75, E12.5, E13.5, E14.5, E15.5, E16.5
Data sources	Manually collected
Reference	27826253; 23460641; 15199404;
Functional description	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Sequence	MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN CSSSSSSFSS 60 PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS GTKNEDCPYS VLEITSVEIG 120 VVAVKAINSN YYLAMNKKGK LYGSKEFNND CKLKERIEEN GYNTYASFNW QHNGRQMYVA 180 LNGKGAPRRG QKTRRKNTSA HFLPMTIQT 209

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	FGF10	612454	J9NVD5			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	FGF10	102174339	A0A142I1Y0			Capra hircus	Prediction	More>>
1:1 ortholog	FGF10	100052655	F7CND4			Equus caballus	Prediction	More>>
1:1 ortholog	FGF10	2255	O15520			Homo sapiens	Publication	More>>
1:1 ortholog	Fgf10	14165	O35565	CPO	E11.5, E11.75, E12.5, E13.5, E14.5, E15.5, E16.5	Mus musculus	Publication	More>>
1:1 ortholog	FGF10	471553	A0A2I3T2G6			Pan troglodytes	Prediction	More>>
1:1 ortholog	FGF10		F1SMG2			Sus scrofa	Prediction	More>>
1:1 ortholog	FGF10	100342802	G1SVA6			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Fgf10	25443	P70492			Rattus norvegicus	Prediction	More>>
1:1 ortholog	fgf10b		A0A0R4ITI2			Danio rerio	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
FGF10	rs10462065C>A	GWAS	28232668

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs245031118	p.Phe32Val	missense variant	-	NC_000079.6:g.118715477T>G	UniProt

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005104	fibroblast growth factor receptor binding	ISO
GO:0005111	type 2 fibroblast growth factor receptor binding	ISO
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	ISO
GO:0008201	heparin binding	ISO
GO:0042056	chemoattractant activity	ISO
GO:0042056	chemoattractant activity	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000132	establishment of mitotic spindle orientation	IGI
GO:0000187	activation of MAPK activity	ISO
GO:0001525	angiogenesis	IEA
GO:0001759	organ induction	ISO
GO:0001759	organ induction	IGI
GO:0001823	mesonephros development	IEA
GO:0001974	blood vessel remodeling	IGI
GO:0003338	metanephros morphogenesis	IMP
GO:0006935	chemotaxis	IDA
GO:0007267	cell-cell signaling	IMP
GO:0007267	cell-cell signaling	IDA
GO:0007368	determination of left/right symmetry	IMP
GO:0007431	salivary gland development	ISO
GO:0007435	salivary gland morphogenesis	IMP
GO:0008284	positive regulation of cell population proliferation	IDA
GO:0008285	negative regulation of cell population proliferation	IDA
GO:0008544	epidermis development	IMP
GO:0008589	regulation of smoothened signaling pathway	IMP
GO:0009880	embryonic pattern specification	IMP
GO:0009887	animal organ morphogenesis	IMP
GO:0009887	animal organ morphogenesis	IDA
GO:0010468	regulation of gene expression	IMP
GO:0010634	positive regulation of epithelial cell migration	ISO
GO:0010634	positive regulation of epithelial cell migration	IDA
GO:0010634	positive regulation of epithelial cell migration	IMP
GO:0010838	positive regulation of keratinocyte proliferation	ISO
GO:0010838	positive regulation of keratinocyte proliferation	IMP
GO:0021983	pituitary gland development	IMP
GO:0030177	positive regulation of Wnt signaling pathway	IMP
GO:0030324	lung development	IDA
GO:0030324	lung development	IMP
GO:0030538	embryonic genitalia morphogenesis	IMP
GO:0030855	epithelial cell differentiation	IMP
GO:0030878	thyroid gland development	IMP
GO:0030916	otic vesicle formation	IGI
GO:0030916	otic vesicle formation	TAS
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP
GO:0031016	pancreas development	IMP
GO:0031069	hair follicle morphogenesis	IMP
GO:0031076	embryonic camera-type eye development	IMP
GO:0031532	actin cytoskeleton reorganization	ISO
GO:0032355	response to estradiol	IEA
GO:0032496	response to lipopolysaccharide	IEA
GO:0032781	positive regulation of ATPase activity	ISO
GO:0032808	lacrimal gland development	ISO
GO:0032808	lacrimal gland development	IMP
GO:0032925	regulation of activin receptor signaling pathway	IMP
GO:0034394	protein localization to cell surface	ISO
GO:0035019	somatic stem cell population maintenance	IMP
GO:0035108	limb morphogenesis	IMP
GO:0035265	organ growth	IMP
GO:0042060	wound healing	ISO
GO:0042246	tissue regeneration	IEA
GO:0042472	inner ear morphogenesis	IMP
GO:0042472	inner ear morphogenesis	IGI
GO:0042475	odontogenesis of dentin-containing tooth	IMP
GO:0042693	muscle cell fate commitment	IMP
GO:0043410	positive regulation of MAPK cascade	ISO
GO:0045596	negative regulation of cell differentiation	IDA
GO:0045739	positive regulation of DNA repair	ISO
GO:0045740	positive regulation of DNA replication	ISO
GO:0045747	positive regulation of Notch signaling pathway	IGI
GO:0045893	positive regulation of transcription, DNA-templated	ISO
GO:0045893	positive regulation of transcription, DNA-templated	IDA
GO:0045931	positive regulation of mitotic cell cycle	IMP
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
GO:0046579	positive regulation of Ras protein signal transduction	ISO
GO:0046877	regulation of saliva secretion	ISO
GO:0048146	positive regulation of fibroblast proliferation	IMP
GO:0048286	lung alveolus development	IGI
GO:0048286	lung alveolus development	IMP
GO:0048514	blood vessel morphogenesis	IMP
GO:0048536	spleen development	IMP
GO:0048538	thymus development	ISO
GO:0048557	embryonic digestive tract morphogenesis	IMP
GO:0048565	digestive tract development	IMP
GO:0048566	embryonic digestive tract development	IMP
GO:0048645	animal organ formation	IMP
GO:0048730	epidermis morphogenesis	IMP
GO:0048752	semicircular canal morphogenesis	IGI
GO:0048754	branching morphogenesis of an epithelial tube	ISO
GO:0048807	female genitalia morphogenesis	IMP
GO:0048808	male genitalia morphogenesis	IMP
GO:0050671	positive regulation of lymphocyte proliferation	ISO
GO:0050673	epithelial cell proliferation	ISO
GO:0050674	urothelial cell proliferation	ISO
GO:0050677	positive regulation of urothelial cell proliferation	ISO
GO:0050679	positive regulation of epithelial cell proliferation	ISO
GO:0050679	positive regulation of epithelial cell proliferation	IMP
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO
GO:0050872	white fat cell differentiation	IMP
GO:0050918	positive chemotaxis	ISO
GO:0050918	positive chemotaxis	IDA
GO:0050930	induction of positive chemotaxis	IDA
GO:0051145	smooth muscle cell differentiation	IMP
GO:0051549	positive regulation of keratinocyte migration	ISO
GO:0060019	radial glial cell differentiation	IMP
GO:0060173	limb development	IMP
GO:0060174	limb bud formation	IMP
GO:0060425	lung morphogenesis	IMP
GO:0060428	lung epithelium development	ISO
GO:0060430	lung saccule development	ISO
GO:0060436	bronchiole morphogenesis	IMP
GO:0060441	epithelial tube branching involved in lung morphogenesis	IMP
GO:0060441	epithelial tube branching involved in lung morphogenesis	IDA
GO:0060445	branching involved in salivary gland morphogenesis	IGI
GO:0060445	branching involved in salivary gland morphogenesis	IDA
GO:0060447	bud outgrowth involved in lung branching	ISO
GO:0060449	bud elongation involved in lung branching	IGI
GO:0060496	mesenchymal-epithelial cell signaling involved in lung development	IDA
GO:0060510	type II pneumocyte differentiation	IDA
GO:0060513	prostatic bud formation	IGI
GO:0060541	respiratory system development	IDA
GO:0060594	mammary gland specification	IGI
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	ISO
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IDA
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IMP
GO:0060615	mammary gland bud formation	IMP
GO:0060661	submandibular salivary gland formation	IMP
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	IGI
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	IMP
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA
GO:0060667	branch elongation involved in salivary gland morphogenesis	IMP
GO:0060879	semicircular canal fusion	IMP
GO:0060915	mesenchymal cell differentiation involved in lung development	IGI
GO:0061033	secretion by lung epithelial cell involved in lung growth	ISO
GO:0061115	lung proximal/distal axis specification	IDA
GO:0070075	tear secretion	ISO
GO:0070352	positive regulation of white fat cell proliferation	IMP
GO:0070371	ERK1 and ERK2 cascade	ISO
GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IGI
GO:0070384	Harderian gland development	IMP
GO:0071157	negative regulation of cell cycle arrest	ISO
GO:0071338	positive regulation of hair follicle cell proliferation	ISO
GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005615	extracellular space	ISO
GO:0005615	extracellular space	IDA
GO:0005623	cell	IEA
GO:0005634	nucleus	ISO
GO:0005886	plasma membrane	ISO
GO:0009986	cell surface	ISO
GO:0062023	collagen-containing extracellular matrix	ISO

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-109704	PI3K Cascade	IEA
R-MMU-112399	IRS-mediated signalling	IEA
R-MMU-1257604	PIP3 activates AKT signaling	IEA
R-MMU-1280215	Cytokine Signaling in Immune system	IEA
R-MMU-162582	Signal Transduction	IEA
R-MMU-168256	Immune System	IEA
R-MMU-190236	Signaling by FGFR	IEA
R-MMU-190241	FGFR2 ligand binding and activation	IEA
R-MMU-190242	FGFR1 ligand binding and activation	IEA
R-MMU-190370	FGFR1b ligand binding and activation	IEA
R-MMU-190377	FGFR2b ligand binding and activation	IEA
R-MMU-199418	Negative regulation of the PI3K/AKT network	IEA
R-MMU-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	IEA
R-MMU-2428924	IGF1R signaling cascade	IEA
R-MMU-2428928	IRS-related events triggered by IGF1R	IEA
R-MMU-5654219	Phospholipase C-mediated cascade: FGFR1	IEA
R-MMU-5654221	Phospholipase C-mediated cascade; FGFR2	IEA
R-MMU-5654687	Downstream signaling of activated FGFR1	IEA
R-MMU-5654688	SHC-mediated cascade:FGFR1	IEA
R-MMU-5654689	PI-3K cascade:FGFR1	IEA
R-MMU-5654693	FRS-mediated FGFR1 signaling	IEA
R-MMU-5654695	PI-3K cascade:FGFR2	IEA
R-MMU-5654696	Downstream signaling of activated FGFR2	IEA
R-MMU-5654699	SHC-mediated cascade:FGFR2	IEA
R-MMU-5654700	FRS-mediated FGFR2 signaling	IEA
R-MMU-5654726	Negative regulation of FGFR1 signaling	IEA
R-MMU-5654727	Negative regulation of FGFR2 signaling	IEA
R-MMU-5654736	Signaling by FGFR1	IEA
R-MMU-5654738	Signaling by FGFR2	IEA
R-MMU-5658623	FGFRL1 modulation of FGFR1 signaling	IEA
R-MMU-5673001	RAF/MAP kinase cascade	IEA
R-MMU-5683057	MAPK family signaling cascades	IEA
R-MMU-5684996	MAPK1/MAPK3 signaling	IEA
R-MMU-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	IEA
R-MMU-74751	Insulin receptor signalling cascade	IEA
R-MMU-74752	Signaling by Insulin receptor	IEA
R-MMU-9006925	Intracellular signaling by second messengers	IEA
R-MMU-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-MMU-9607240	FLT3 Signaling	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0325	Glycoprotein
KW-0339	Growth factor
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal

Interpro

InterPro ID	InterPro Term
IPR028252	FGF10
IPR002209	Fibroblast_GF_fam
IPR008996	IL1/FGF

PROSITE

PROSITE ID	PROSITE Term
PS00247	HBGF_FGF

Pfam

Pfam ID	Pfam Term
PF00167	FGF

Gene: Fgf10

Basic information

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction