Gene: Fgf10

Basic information

Tag Content
Uniprot ID P70492
Entrez ID 25443
Genbank protein ID BAA11468.1
Genbank nucleotide ID NM_012951.1
Ensembl protein ID ENSRNOP00000016485
Ensembl nucleotide ID ENSRNOG00000012278
Gene name Fibroblast growth factor 10
Gene symbol Fgf10
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Sequence
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SVPVTCQALG QDMVSPEATN SSSSSSSSSS 60
SSSFSSPSSA GRHVRSYNHL QGDVRWRKLF SFTKYFLKIE KNGKVSGTKK ENCPYSILEI 120
TSVEIGVVAV KAINSNYYLA MNKKGKLYGS KEFNNDCKLK ERIEENGYNT YASFNWQHNG 180
RQMYVALNGK GAPRRGQKTR RKNTSAHFLP MVVHS 215

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFGF10612454J9NVD5Canis lupus familiarisPredictionMore>>
1:1 orthologFGF10102174339A0A142I1Y0Capra hircusPredictionMore>>
1:1 orthologFGF10100052655F7CND4Equus caballusPredictionMore>>
1:1 orthologFGF102255O15520Homo sapiensPublicationMore>>
1:1 orthologFgf1014165O35565CPOE11.5, E11.75, E12.5, E13.5, E14.5, E15.5, E16.5Mus musculusPublicationMore>>
1:1 orthologFGF10471553A0A2I3T2G6Pan troglodytesPredictionMore>>
1:1 orthologFGF10F1SMG2Sus scrofaPredictionMore>>
1:1 orthologFGF10100342802G1SVA6Oryctolagus cuniculusPredictionMore>>
1:1 orthologFgf1025443P70492Rattus norvegicusPredictionMore>>
1:1 orthologfgf10bA0A0R4ITI2Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005623 cell
GO:0009986 cell surface
GO:0062023 collagen-containing extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0042056 chemoattractant activity
GO:0005104 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0031532 actin cytoskeleton reorganization
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0048645 animal organ formation
GO:0009887 animal organ morphogenesis
GO:0048514 blood vessel morphogenesis
GO:0001974 blood vessel remodeling
GO:0060667 branch elongation involved in salivary gland morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0060436 bronchiole morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060447 bud outgrowth involved in lung branching
GO:0030154 cell differentiation
GO:0007267 cell-cell signaling
GO:0006935 chemotaxis
GO:0007368 determination of left/right symmetry
GO:0048565 digestive tract development
GO:0031076 embryonic camera-type eye development
GO:0048566 embryonic digestive tract development
GO:0048557 embryonic digestive tract morphogenesis
GO:0030538 embryonic genitalia morphogenesis
GO:0009880 embryonic pattern specification
GO:0008544 epidermis development
GO:0048730 epidermis morphogenesis
GO:0030855 epithelial cell differentiation
GO:0050673 epithelial cell proliferation
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070371 ERK1 and ERK2 cascade
GO:0000132 establishment of mitotic spindle orientation
GO:0048807 female genitalia morphogenesis
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069 hair follicle morphogenesis
GO:0070384 Harderian gland development
GO:0050930 induction of positive chemotaxis
GO:0042472 inner ear morphogenesis
GO:0032808 lacrimal gland development
GO:0060174 limb bud formation
GO:0060173 limb development
GO:0035108 limb morphogenesis
GO:0048286 lung alveolus development
GO:0030324 lung development
GO:0060428 lung epithelium development
GO:0060425 lung morphogenesis
GO:0061115 lung proximal/distal axis specification
GO:0060430 lung saccule development
GO:0048808 male genitalia morphogenesis
GO:0060615 mammary gland bud formation
GO:0060594 mammary gland specification
GO:0060915 mesenchymal cell differentiation involved in lung development
GO:0060496 mesenchymal-epithelial cell signaling involved in lung development
GO:0001823 mesonephros development
GO:0001656 metanephros development
GO:0003338 metanephros morphogenesis
GO:0042693 muscle cell fate commitment
GO:0071157 negative regulation of cell cycle arrest
GO:0045596 negative regulation of cell differentiation
GO:0008285 negative regulation of cell population proliferation
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0042475 odontogenesis of dentin-containing tooth
GO:0035265 organ growth
GO:0001759 organ induction
GO:0030916 otic vesicle formation
GO:0031016 pancreas development
GO:0021983 pituitary gland development
GO:0050918 positive chemotaxis
GO:0032781 positive regulation of ATPase activity
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0045739 positive regulation of DNA repair
GO:0010634 positive regulation of epithelial cell migration
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0048146 positive regulation of fibroblast proliferation
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:0071338 positive regulation of hair follicle cell proliferation
GO:0051549 positive regulation of keratinocyte migration
GO:0010838 positive regulation of keratinocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0043410 positive regulation of MAPK cascade
GO:0045931 positive regulation of mitotic cell cycle
GO:0045747 positive regulation of Notch signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050677 positive regulation of urothelial cell proliferation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0070352 positive regulation of white fat cell proliferation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0060513 prostatic bud formation
GO:0034394 protein localization to cell surface
GO:0060019 radial glial cell differentiation
GO:0032925 regulation of activin receptor signaling pathway
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0010468 regulation of gene expression
GO:0046877 regulation of saliva secretion
GO:0008589 regulation of smoothened signaling pathway
GO:0060541 respiratory system development
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0014070 response to organic cyclic compound
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0061033 secretion by lung epithelial cell involved in lung growth
GO:0060879 semicircular canal fusion
GO:0048752 semicircular canal morphogenesis
GO:0051145 smooth muscle cell differentiation
GO:0035019 somatic stem cell population maintenance
GO:0048536 spleen development
GO:0060661 submandibular salivary gland formation
GO:0070075 tear secretion
GO:0048538 thymus development
GO:0030878 thyroid gland development
GO:0042246 tissue regeneration
GO:0060510 type II pneumocyte differentiation
GO:0050674 urothelial cell proliferation
GO:0050872 white fat cell differentiation
GO:0042060 wound healing

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0325 Glycoprotein
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR028252 FGF10
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

PROSITE

PROSITE ID PROSITE Term
PS00247 HBGF_FGF

Pfam

Pfam ID Pfam Term
PF00167 FGF