| Tag | Content |
|---|---|
| Uniprot ID | F8W5M6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000125042 |
| Ensembl nucleotide ID | ENSDARG00000095859 |
| Gene name | Protein patched homolog 1 |
| Gene symbol | ptch1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASAVNVSSE QENRDPDRPR VTRRNRGNYR TAAADLEYLQ RPSYCDAAFA LEQISEGNAT 60 GRKAPLWLRA KFQRLLFKLG CYIQKNCGKF LVVGLLIFGA FAVGLRAANL ETDVEKLWVE 120 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTCH1 | A0A452EIX7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PTCH1 | 5727 | Q13635 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Ptch1 | 19206 | Q61115 | CPO,CLP,CLO | E13.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PTCH1 | 465254 | A0A2J8JHA7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Ptch1 | 89830 | Q6UY90 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ptch1 | F8W5M6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0097108 | hedgehog family protein binding |
| GO:0008158 | hedgehog receptor activity |
| GO:0005119 | smoothened binding |
| GO:0010002 | cardioblast differentiation |
| GO:0001957 | intramembranous ossification |
| GO:0048635 | negative regulation of muscle organ development |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0001649 | osteoblast differentiation |
| GO:0060041 | retina development in camera-type eye |
| GO:0060042 | retina morphogenesis in camera-type eye |
| GO:0007224 | smoothened signaling pathway |