| Tag | Content |
|---|---|
| Uniprot ID | Q6UY90 |
| Entrez ID | 89830 |
| Genbank protein ID | AAQ67738.1 |
| Genbank nucleotide ID | NM_053566.1 |
| Ensembl protein ID | ENSRNOP00000026287 |
| Ensembl nucleotide ID | ENSRNOG00000019354 |
| Gene name | Patched |
| Gene symbol | Ptch1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASAGNAAGA LGRQAGGGRR RRTGGPHRAA PDRDYLHRPS YCDAAFALEQ ISKGKATGRK 60 APLWLRAKFQ RLLFKLGCYI QKNCGKFLVV GLLIFGAFAV GLKAANLETN VEELWVEVGG 120 RVSRELNYTR QKIGEEAMFN PQLMIQTPKE EGANVLTTEA LLQHLDSALQ ASRVHVYMYN 180 RQWKLEHLCY KSGELITETG YMDQIIEYLY PCLIITPLDC FWEGAKLQSG TAYLLGKPPL 240 RWTNFDPLEF LEELKKINYQ VDSWEEMLNK AEVGHGYMDR PCLNPADPDC PATAPNKNST 300 KPLDVALVLN GGCQGLSRKY MHWQEELIVG GTVKNATGKL VSAHALQTMF QLMTPKQMYE 360 HFRGYDYVSH INWNEDRAAA ILEAWQRTYV EVVHQSVAPN STQKVLSFTT TTLDDILKSF 420 SDVSVIRVAS GYLLMLAYAC LTMLRWDCSK SQGAVGLAGV LLVALSVAAG LGLCSLIGIS 480 FNAATTQVLP FLALGVGVDD VFLLAHAFSE TGQNKRIPFE DRTGECLKRT GASVALTSIS 540 NVTAFFMAAL IPIPALRAFS LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF 600 TSPCVSRVIQ VEPQAYTEPH SNTRYSPPPP YSSHSFAHET HITMQSTVQL RTEYDPHTHV 660 YYTTAEPRSE ISVQPVTITQ DTLSCQSPES TSSTRDLLSQ FSDSSLHCLE PPCTKWTLSS 720 FAEKHYAPFL LRPKAKVVVI LLFLGLLGVS LYGTTRVRDG LDLTDIVPRE TREYDFIAAQ 780 FKYFSFYNMY IVTQKADYPN IQHLLYDLHK SFSSVKYVML EENKQLPQMW LHYFRDWLQG 840 LQDAFDSDWE TGRIMPNNYK NGSDDGVLAY KLLVQTGSRD KPIDISQLTK QRLVDADGII 900 NPSAFYIYLT AWVSNDPVAY AASQANIRPH RPEWVHDKAD YMPETRLRIP AAEPIEYAQF 960 PFYLNGLRDT SDFVEAIEKV RVICNNYTSL GLSSYPNGYP FLFWEQYISL RHWLLLAISV 1020 VLACTFLVCA VFLLNPWTAG IIVMVLALMT VELFGMMGLI GIKLSAVPVV ILIASVGIGV 1080 EFTVHVALAF LTAIGDKNHR AMLALEHMFA PVLDGAVSTL LGVLMLAGSE FDFIVRYFFA 1140 VLAILTVLGV LNGLVLLPVL LSFFGPCPEV SPANGLNRLP TPSPEPPPSV VRFAVPPGHT 1200 NNGSDSSDSE YSSQTTVSGI SEELRHYEAQ QGTGGPAHQV IVEATENPVF ARSTVVHPDS 1260 RHQPPLNSRQ QPHLDSGSLS PGRQGQQPRR DPPREGLRPP PYRPRRDAFE ISTEGHSGPS 1320 NRDRSGPHGA RSHNPRNPTS TAMGSSVPSY CQPITTVTAS ASVTVAVHPP PGPGRNPRGG 1380 PCPGYESYPE TDHGVFEDPH VPFHVRCERR DSKVEVIELQ DVECEERPWG SSSN 1434 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTCH1 | A0A452EIX7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PTCH1 | 5727 | Q13635 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Ptch1 | 19206 | Q61115 | CPO,CLP,CLO | E13.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PTCH1 | 465254 | A0A2J8JHA7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Ptch1 | 89830 | Q6UY90 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ptch1 | F8W5M6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0044295 | axonal growth cone |
| GO:0005901 | caveola |
| GO:0005929 | cilium |
| GO:0044294 | dendritic growth cone |
| GO:0005794 | Golgi apparatus |
| GO:0016021 | integral component of membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0030496 | midbody |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0005886 | plasma membrane |
| GO:0014069 | postsynaptic density |
| GO:0015485 | cholesterol binding |
| GO:0030332 | cyclin binding |
| GO:0097108 | hedgehog family protein binding |
| GO:0008158 | hedgehog receptor activity |
| GO:0008201 | heparin binding |
| GO:0005113 | patched binding |
| GO:0044877 | protein-containing complex binding |
| GO:0005119 | smoothened binding |
| GO:0009887 | animal organ morphogenesis |
| GO:0007420 | brain development |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0061005 | cell differentiation involved in kidney development |
| GO:0001709 | cell fate determination |
| GO:0072203 | cell proliferation involved in metanephros development |
| GO:0071397 | cellular response to cholesterol |
| GO:0071679 | commissural neuron axon guidance |
| GO:0021904 | dorsal/ventral neural tube patterning |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048568 | embryonic organ development |
| GO:0009957 | epidermal cell fate specification |
| GO:0008544 | epidermis development |
| GO:0042593 | glucose homeostasis |
| GO:0003007 | heart morphogenesis |
| GO:0035137 | hindlimb morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0043616 | keratinocyte proliferation |
| GO:0035108 | limb morphogenesis |
| GO:0097421 | liver regeneration |
| GO:0030879 | mammary gland development |
| GO:0060603 | mammary gland duct morphogenesis |
| GO:0060644 | mammary gland epithelial cell differentiation |
| GO:0072205 | metanephric collecting duct development |
| GO:0051782 | negative regulation of cell division |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0050680 | negative regulation of epithelial cell proliferation |
| GO:0040015 | negative regulation of multicellular organism growth |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0021997 | neural plate axis specification |
| GO:0001843 | neural tube closure |
| GO:0001841 | neural tube formation |
| GO:0021532 | neural tube patterning |
| GO:0007389 | pattern specification process |
| GO:0060037 | pharyngeal system development |
| GO:0010875 | positive regulation of cholesterol efflux |
| GO:0045606 | positive regulation of epidermal cell differentiation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0030850 | prostate gland development |
| GO:0072659 | protein localization to plasma membrane |
| GO:0016485 | protein processing |
| GO:0042127 | regulation of cell population proliferation |
| GO:0040008 | regulation of growth |
| GO:0007346 | regulation of mitotic cell cycle |
| GO:0032880 | regulation of protein localization |
| GO:0008589 | regulation of smoothened signaling pathway |
| GO:0010157 | response to chlorate |
| GO:0042493 | response to drug |
| GO:0032355 | response to estradiol |
| GO:0009612 | response to mechanical stimulus |
| GO:0014070 | response to organic cyclic compound |
| GO:0032526 | response to retinoic acid |
| GO:0007165 | signal transduction |
| GO:0048745 | smooth muscle tissue development |
| GO:0007224 | smoothened signaling pathway |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0061053 | somite development |
| GO:0021522 | spinal cord motor neuron differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50156 | SSD |