Gene: ALDH1A2

Basic information

Tag Content
Uniprot ID G1TCP3
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSOCUP00000014561
Ensembl nucleotide ID ENSOCUG00000016942
Gene name Aldehyde dehydrogenase 1 family member A2
Gene symbol ALDH1A2
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTSSKIEMPG EVKADPAALM ASLHLLPSPT PNLEIKYTKI FINNEWQNSE SGRVFPVYNP 60
ATGEQVCEVQ EADKADIDKA VQAARLAFSL GSVWRRMDAS ERGRLLDKLA DLVERDRAVL 120
ATMESLNGGK PFLQAFYVDL QGVIKTLRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC 180
GQIIPWNFPL LMFAWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVINILP 240
GYGPTAGAAI ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 300
LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVRRS VERAKRRIVG SPFDPTTEQG 360
PQIDKKQYNK ILELIQSGVA EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG 420
PVQEILRFKT MDEVIERANN SDFGLVAAVF TNDINKALTV SSAMQAGTVW INCYNALNAQ 480
SPFGGFKMSG NGREMGEFGL REYSEVKTVT DPALRNTKLS HSPDLKMEMI TCRPGRYRTT 540
RANQLGMVSW HSVRGHPNDT KHGGKWGQGQ TQMPGALGRS KYLLLEQGMG

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALDH1A2478319F1PGT3Canis lupus familiarisPredictionMore>>
1:1 orthologALDH1A2102181689A0A452G5H4Capra hircusPredictionMore>>
1:1 orthologALDH1A2100054550F7CVL4Equus caballusPredictionMore>>
1:1 orthologALDH1A28854O94788Homo sapiensPredictionMore>>
1:1 orthologAldh1a219378Q62148CPO,CLOMus musculusPublicationMore>>
1:1 orthologALDH1A2A0A2I3SDX9Pan troglodytesPredictionMore>>
1:1 orthologALDH1A2I3LK62Sus scrofaPredictionMore>>
1:1 orthologALDH1A2G1TCP3Oryctolagus cuniculusPredictionMore>>
1:1 orthologAldh1a2116676Q63639Rattus norvegicusPredictionMore>>
1:1 orthologaldh1a2Q90Y03Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
GO:0001758 retinal dehydrogenase activity
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0001568 blood vessel development
GO:0048738 cardiac muscle tissue development
GO:0071300 cellular response to retinoic acid
GO:0009855 determination of bilateral symmetry
GO:0031076 embryonic camera-type eye development
GO:0048566 embryonic digestive tract development
GO:0035115 embryonic forelimb morphogenesis
GO:0060324 face development
GO:0030900 forebrain development
GO:0003007 heart morphogenesis
GO:0030902 hindbrain development
GO:0030324 lung development
GO:0016331 morphogenesis of embryonic epithelium
GO:0008285 negative regulation of cell population proliferation
GO:0014032 neural crest cell development
GO:0021915 neural tube development
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0043065 positive regulation of apoptotic process
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0051289 protein homotetramerization
GO:0009954 proximal/distal pattern formation
GO:0001936 regulation of endothelial cell proliferation
GO:0034097 response to cytokine
GO:0042574 retinal metabolic process
GO:0090242 retinoic acid receptor signaling pathway involved in somitogenesis
GO:0035799 ureter maturation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0560 Oxidoreductase
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom

PROSITE

PROSITE ID PROSITE Term
PS00070 ALDEHYDE_DEHYDR_CYS
PS00687 ALDEHYDE_DEHYDR_GLU

Pfam

Pfam ID Pfam Term
PF00171 Aldedh