| Tag | Content |
|---|---|
| Uniprot ID | Q63639; Q4FZY8; |
| Entrez ID | 116676 |
| Genbank protein ID | AAC52637.1; AAH98910.1; |
| Genbank nucleotide ID | NM_053896.2 |
| Ensembl protein ID | ENSRNOP00000073203 |
| Ensembl nucleotide ID | ENSRNOG00000055049 |
| Gene name | Retinal dehydrogenase 2 |
| Gene symbol | Aldh1a2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral. |
| Sequence | MTSSEIAMPG EVKADPAALM ASLQLLPSPT PNLEIKYTKI FINNEWQNSE SGRVFPVCNP 60 ATGEQVCEVQ EADKVDIDKA VQAARLAFSL GSVWRRMDAS ERGRLLDKLA DLVERDRATL 120 ATMESLNGGK PFLQAFYIDL QGVIKTLRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC 180 GQIIPWNFPL LMFTWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP 240 GYGPTAGAAI ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 300 LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVKRS VERAKRRIVG SPFDPTTEQG 360 PQIDKKQYNK ILELIQSGVA EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG 420 PVQEILRFKT MDEVIERANN SDFGLVAAVF TNDINKALMV SSAMQAGTVW INCYNALNAQ 480 SPFGGFKMSG NGREMGEFGL REYSEVKTVT VKIPQKNS 518 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ALDH1A2 | 478319 | F1PGT3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ALDH1A2 | 102181689 | A0A452G5H4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ALDH1A2 | 100054550 | F7CVL4 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ALDH1A2 | 8854 | O94788 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Aldh1a2 | 19378 | Q62148 | CPO,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ALDH1A2 | A0A2I3SDX9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ALDH1A2 | I3LK62 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ALDH1A2 | G1TCP3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Aldh1a2 | 116676 | Q63639 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | aldh1a2 | Q90Y03 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| GO:0004029 | aldehyde dehydrogenase (NAD+) activity |
| GO:0016918 | retinal binding |
| GO:0001758 | retinal dehydrogenase activity |
| GO:0042904 | 9-cis-retinoic acid biosynthetic process |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0001568 | blood vessel development |
| GO:0043010 | camera-type eye development |
| GO:0048738 | cardiac muscle tissue development |
| GO:0071300 | cellular response to retinoic acid |
| GO:0009855 | determination of bilateral symmetry |
| GO:0031076 | embryonic camera-type eye development |
| GO:0048566 | embryonic digestive tract development |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0060324 | face development |
| GO:0030900 | forebrain development |
| GO:0003007 | heart morphogenesis |
| GO:0030902 | hindbrain development |
| GO:0001822 | kidney development |
| GO:0001889 | liver development |
| GO:0030324 | lung development |
| GO:0007494 | midgut development |
| GO:0016331 | morphogenesis of embryonic epithelium |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0014032 | neural crest cell development |
| GO:0021915 | neural tube development |
| GO:0030182 | neuron differentiation |
| GO:0031016 | pancreas development |
| GO:0021983 | pituitary gland development |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0010628 | positive regulation of gene expression |
| GO:0051289 | protein homotetramerization |
| GO:0009954 | proximal/distal pattern formation |
| GO:0001936 | regulation of endothelial cell proliferation |
| GO:0034097 | response to cytokine |
| GO:0032355 | response to estradiol |
| GO:0033189 | response to vitamin A |
| GO:0042574 | retinal metabolic process |
| GO:0002138 | retinoic acid biosynthetic process |
| GO:0042573 | retinoic acid metabolic process |
| GO:0048384 | retinoic acid receptor signaling pathway |
| GO:0090242 | retinoic acid receptor signaling pathway involved in somitogenesis |
| GO:0042572 | retinol metabolic process |
| GO:0035799 | ureter maturation |
| Pfam ID | Pfam Term |
|---|---|
| PF00171 | Aldedh |