Gene: aldh1a2

Basic information

Tag Content
Uniprot ID Q90Y03
Entrez ID
Genbank protein ID AAL26232.1
Genbank nucleotide ID
Ensembl protein ID ENSDARP00000149388; ENSDARP00000070001;
Ensembl nucleotide ID ENSDARG00000113122; ENSDARG00000053493;
Gene name Aldehyde dehydrogenase 1 family, member A2
Gene symbol aldh1a2
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTSSEVELPG EVKNDPAALM ASLHLMPSPV PNPEIKYTKI FINNEWHDSV SGKVFHTYNP 60
ATGEKICDVQ ESDKADVDKA VQAARSAFSL GSVWRKMDAS ERGKLLFKLA DLVERDSAYL 120
ATLESLDSGK PFLPCFFVDL QGIIKTFRYY AGWADKIHGS TIPIDGEFFT LTRHEPIGVC 180
GQIIPWNFPL VMTAWKLGPA LSCGNTVVLK PAEQTPLTCL YLGALIKEAG FPPGVVNILP 240
GYGPTAGAAI SSHMGIDKVA FTGSTEVGKL IQEAAGKSNL KRVTLELGGK SPNIIFADAD 300
FELALEQAHQ GVFFNNGQCC TAGSRIFVEE PIYDEFVRRS VERAQRRKVG NPFDPTTEHG 360
PQVSEEQQRR VLELIQSGIT EGAKLECGGK APPTKGFFVE PTVFSNVKDH MRIAKEEIFG 420
PVQQIMKFKT IEEVIERANN TEYGLAAAVF TRDISKAMTI SAAVQAGTVW INCYNALSCQ 480
CPFGGFKMSG NGRELGEIGL KEYTELKTIT MKMSGKTS 518

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALDH1A2478319F1PGT3Canis lupus familiarisPredictionMore>>
1:1 orthologALDH1A2102181689A0A452G5H4Capra hircusPredictionMore>>
1:1 orthologALDH1A2100054550F7CVL4Equus caballusPredictionMore>>
1:1 orthologALDH1A28854O94788Homo sapiensPredictionMore>>
1:1 orthologAldh1a219378Q62148CPO,CLOMus musculusPublicationMore>>
1:1 orthologALDH1A2A0A2I3SDX9Pan troglodytesPredictionMore>>
1:1 orthologALDH1A2I3LK62Sus scrofaPredictionMore>>
1:1 orthologALDH1A2G1TCP3Oryctolagus cuniculusPredictionMore>>
1:1 orthologAldh1a2116676Q63639Rattus norvegicusPredictionMore>>
1:1 orthologaldh1a2Q90Y03Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0009952 anterior/posterior pattern specification
GO:0048318 axial mesoderm development
GO:0048593 camera-type eye morphogenesis
GO:0022010 central nervous system myelination
GO:0007368 determination of left/right symmetry
GO:0048546 digestive tract morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0060325 face morphogenesis
GO:0031101 fin regeneration
GO:0072015 glomerular visceral epithelial cell development
GO:0021575 hindbrain morphogenesis
GO:0001889 liver development
GO:0022011 myelination in peripheral nervous system
GO:0031016 pancreas development
GO:0061131 pancreas field specification
GO:0048339 paraxial mesoderm development
GO:0033339 pectoral fin development
GO:0039023 pronephric duct morphogenesis
GO:0048793 pronephros development
GO:0048385 regulation of retinoic acid receptor signaling pathway
GO:0048384 retinoic acid receptor signaling pathway
GO:0042572 retinol metabolic process
GO:0001756 somitogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0560 Oxidoreductase
KW-1267 Proteomics identification
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom

PROSITE

PROSITE ID PROSITE Term
PS00070 ALDEHYDE_DEHYDR_CYS
PS00687 ALDEHYDE_DEHYDR_GLU

Pfam

Pfam ID Pfam Term
PF00171 Aldedh