Gene: Jarid2

Basic information

Tag Content
Uniprot ID G3UZT8
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSMUSP00000134630
Ensembl nucleotide ID ENSMUSG00000038518
Gene name Protein Jumonji
Gene symbol Jarid2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage E14.5, E15.5
Data sources Homology search
Reference
Functional description
Sequence
MAAPRVCQVQ FLVAYLEEPG IEGLLGNAQA KALGPASEQS ENEKDDASQV SSTSNDVSSS 60
DFEEGPSRKR PRLQAQRKFA QSQPNSPSTT PVKIVEPLLP PPATQISDLS KRKPKTEDFL 120
TFLCLRGSPA LPNSMVYFGS SQDEEDVEEE DDETEDVKAT TNNASSSCQS TPRKGKTHKH 180
VHNGHVFNGS SRSAREKEPA HKHRSKEATP GKEKHSEPRA DSRREQASGA QPTAASAAAS 240
SAKGLAANHQ PPPSHRSAQD LRKQVSKVNG VTRMSSLGAG TNSAKKIREV RPSPSKTVKY 300
TATVTKGTVT YTKAKRELVK ETKPNHHKPS SAVNHTISGK TESSNAKTRK QVLSLGGASK 360
STGPAASGLK ASSRLNPKSC TKEVGGRQLR EGLRNSKRRL EEAQQVDKPQ SPPKKMKGVA 420
GNAEAPGKKA SAASGEKSLL NGHVKKEVPE RSLERNRPKR AAAGKNMLGK QAHGKTEGTP 480
CENRSTSQPE SSHKPHDPQG KPEKGSGKSG WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ 540
VEKYGMCRVI PPPDWRPECK LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLRSQGI 600
TMDELPLIGG CELDLACFFR LINEMGGMQQ VTDLKKWNKL ADMLRIPKTA QDRLAKLQEA 660
YCQYLLSYDS LSPEEHRRLE KEVLMEKEIL EKRKGPLEGH TESDHHKFHS LPRFEPKNGL 720
VHGVTPRNGF RSKLKEVGRA PLKTGRRRLF AQEKEVVKEE EEDKGVLNDF HKCIYKGRSV 780
SLTTFYRTAR NIMNMCFSKE PAPAEIEQEY WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG 840
KSEPFSRHGW NLTVLPNNTG SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY 900
LHTGADCIWY CIPAEEENKL EDVVHTLLQG NGTPGLQMLE SNVMISPEVL CKKGIKVHRT 960
VQQSGQFVVC FPGSFVSKVC CGYNVSETVH FATTQWTSMG FETAKEMKRR HIAKPFSMEK 1020
LLYQIAQAE 1029

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologJARID2478729A0A5F4DE24Canis lupus familiarisPredictionMore>>
1:1 orthologJARID2102184681A0A452DTS6Capra hircusPredictionMore>>
1:1 orthologJARID23720Q92833CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologJarid2G3UZT8E14.5, E15.5Mus musculusPredictionMore>>
1:1 orthologJARID2462450A0A2I3SRS8Pan troglodytesPredictionMore>>
1:1 orthologJARID2A0A287AMW5Sus scrofaPredictionMore>>
1:1 orthologJarid2681740M0RBV7Rattus norvegicusPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
JARID2rs2237138T>CGenotyping -SNaPshot minisequencing technique.25155265
JARID2rs2072820T>CLinkage disequilibrium study20506229
JARID2rs2237149C>ALinkage disequilibrium study20506229
JARID2rs2299043G>ALinkage disequilibrium study20506229
JARID2rs2237138T>CLinkage disequilibrium study20506229
JARID2rs2076056C>GLinkage disequilibrium study20506229
JARID2rs2282819G>ALinkage disequilibrium study20506229

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence

GO:Biological Process

GO ID GO Term Evidence

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0539 Nucleus
KW-1267 Proteomics identification
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR003347 JmjC_dom
IPR003349 JmjN

PROSITE

PROSITE ID PROSITE Term
PS51011 ARID
PS51184 JMJC
PS51183 JMJN

Pfam

Pfam ID Pfam Term
PF01388 ARID
PF02373 JmjC
PF02375 JmjN

Protein-miRNA interaction