Gene: Sclt1

Basic information

Tag Content
Uniprot ID G5E861; Q6PAJ0; Q9CSV4; Q9CUR9;
Entrez ID 67161
Genbank protein ID BAB27908.1; EDL35173.1; AAH60271.1; BAB29547.1; AAH43136.1;
Genbank nucleotide ID NM_001081411.1
Ensembl protein ID ENSMUSP00000026866; ENSMUSP00000123392;
Ensembl nucleotide ID ENSMUSG00000059834
Gene name Sodium channel and clathrin linker 1
Gene symbol Sclt1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 28486600
Functional description Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity).
Sequence
MATEIDLLRD QKDKLNDILR QHQIEHIFRD PTMQNSMSKG GRGDTLVDSI NEQSSLPPLI 60
AEYEKHLEEL NRQLTYYQKH MGEMKLQLET VITENERLHS KLKDAVEKQL EALPFGTGIG 120
NDICADDETV RILQEQLQLA NQEKTWALEL WQTASQELQS VQKLYQEHMT EAQIHEFENR 180
KQKDQLNNFQ QLTKKLHVAN ENIEMTNHHF LKTVTEQNME IEKLRKHLRQ ARLDLRVAVS 240
KVEELTKVTE GLQEQMLKKE EDIMSAQGKE EASDRRVQQL QSSIKQLESR LCVAIEEADV 300
LKTGKSNLEK QIKELQAKCS ESENEKYEAI SRARDSMQLL EEANIKQNQI LLEEKQKEVD 360
REKMKKTMSQ LIQDAAIKAR KEVESTKKQY EILISQLKEE LSTLQMDCDE KQGQIDRAIR 420
GKRAVEEELE KIYREGKQDE SDYRKLEEMH QRCLAAERSK DDLQLRLKSA ENRIKQLEIN 480
SSEEMSRSHE MIQKLQTVLE SERENCGFVS EQRLKLQQEN EQLQKETEDL RKVALEAQKK 540
AKLKVSTMEH QFSIKEHGFE VQLREMEDSN RNSIVELRHL LAAQQKTANR WKEETKKLTE 600
SAEMRISSLK SELSRQKLHT QELLSQLEMA NEKVAENEKL ILEHQEKANR LQRRLSQAEE 660
RAASASQQLS VITVQRRKAA SMMNLENI 688

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSCLT1A0A452G9W1Capra hircusPredictionMore>>
1:1 orthologSCLT1100071834F6X4D8Equus caballusPredictionMore>>
1:1 orthologSCLT1132320Q96NL6Homo sapiensPredictionMore>>
1:1 orthologSclt167161G5E861CPOMus musculusPublicationMore>>
1:1 orthologSCLT1461486H2QQ60Pan troglodytesPredictionMore>>
1:1 orthologA0A4X1VFW7Sus scrofaPredictionMore>>
1:1 orthologSclt1266809Q8CJ99Rattus norvegicusPredictionMore>>
1:1 orthologsclt1561057E7EZ46Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0008022 protein C-terminus bindingISO
GO:0017080 sodium channel regulator activityISO
GO:0030276 clathrin bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0045162 clustering of voltage-gated sodium channelsISO
GO:0060271 cilium assemblyISO
GO:0060271 cilium assemblyISS

GO:Cellular Component

GO ID GO Term Evidence
GO:0005813 centrosomeISO
GO:0005814 centrioleISS
GO:0005814 centrioleISO
GO:0005814 centrioleIDA
GO:0071439 clathrin complexISO
GO:0097539 ciliary transition fiberISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1852241 Organelle biogenesis and maintenanceIEA
R-MMU-5617833 Cilium AssemblyIEA
R-MMU-5620912 Anchoring of the basal body to the plasma membraneIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0025 Alternative splicing
KW-0175 Coiled coil
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR038911 SCLT1

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term

Protein-miRNA interaction