| Tag | Content |
|---|---|
| Uniprot ID | Q8CJ99; Q8CJ83; Q8CJ84; Q8CJ98; |
| Entrez ID | 266809 |
| Genbank protein ID | AAN63529.1; AAN32725.1; AAN32724.1; AAN63528.1; |
| Genbank nucleotide ID | NM_153740.1 |
| Ensembl protein ID | ENSRNOP00000019256 |
| Ensembl nucleotide ID | ENSRNOG00000014139 |
| Gene name | Sodium channel and clathrin linker 1 |
| Gene symbol | Sclt1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization. |
| Sequence | MATEIDLLRD QNVKLNDILR QHQIEHIFRD PAMQNSMSKG GRGDTLTNSV NDQSALPPLI 60 AEYEKHLEEL NRQLTYYQKH MGEMKLQLET VITENERLHS KLKDAVEKQL EALPFGTGIG 120 NDICADDETV RNLQEQLQIA NQEKNWAVQL WQTASQELES VQKLYQEHMT EAQIHVFENR 180 KQKDQLNNFQ QLTKKLHVAN ENIEMTNHHF LKTVTEQNME IEKLRKQLRQ AKLDLRVAVT 240 KVEELTKVTE GLQEQMLKKE EDIMSAQGKE EASDRRVQQL QSSIKQLESR LCIAIQEANV 300 LKTGKTQLEK QIKELQAKCS ESENEKYEAI SRARDSMQLL EEANIKQNQI LLEEKQKEVE 360 REKMKKTISH LIQDAAIKAR KEVESTKKQY EVLILQLKEE LSALQMDCDE KQGQIDRAIR 420 GKRAVEEELE KIYREGKQDE GDYRKLEEMH QRCLAAERSK DDLQLRLKTA ENRIKQLEIN 480 SSEEISRSHE MIQKLQTVLE SERENCGFVS EQRLKLQQEN EQLQKETEDL RKVALEAQKK 540 AKLKVSTMEH QFSIKEHGFE VQLREMEDSN RNSIVELRHL LAAQQKTANR WKEETKKLTE 600 SAEMRISSLK SELSRQKLHT QELLSQLEMA NEKVAENEKL ILEHQEKANR LQRRLSQAEE 660 RAASASQQLS VITVQRRKAA SMMNLENI 688 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SCLT1 | A0A452G9W1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SCLT1 | 100071834 | F6X4D8 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SCLT1 | 132320 | Q96NL6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sclt1 | 67161 | G5E861 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SCLT1 | 461486 | H2QQ60 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1VFW7 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Sclt1 | 266809 | Q8CJ99 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sclt1 | 561057 | E7EZ46 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005814 | centriole |
| GO:0005813 | centrosome |
| GO:0097539 | ciliary transition fiber |
| GO:0071439 | clathrin complex |
| GO:0030276 | clathrin binding |
| GO:0008022 | protein C-terminus binding |
| GO:0017080 | sodium channel regulator activity |
| GO:0060271 | cilium assembly |
| GO:0045162 | clustering of voltage-gated sodium channels |
| InterPro ID | InterPro Term |
|---|---|
| IPR038911 | SCLT1 |