Gene: NTN1

Basic information

Tag Content
Uniprot ID H2QC90; K7CDB2;
Entrez ID 455083
Genbank protein ID JAA22145.1
Genbank nucleotide ID XM_016932409.1; XM_016932411.1; XM_016932410.1;
Ensembl protein ID ENSPTRP00000014909
Ensembl nucleotide ID ENSPTRG00000008752
Gene name Netrin 1
Gene symbol NTN1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF 60
GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK KAHPPAFLTD LNNPHNLTCW 120
QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ 180
CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD 240
WVTATDIRVA FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD 300
SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS 360
GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT 420
GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK 480
GKLKINMKKY CKKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR 540
DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK 600
CKKA 604

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNTN1522767F1N0C7Bos taurusPredictionMore>>
1:1 orthologNTN1A0A452FGQ4Capra hircusPredictionMore>>
1:1 orthologNTN19423O95631Homo sapiensPublicationMore>>
1:1 orthologNtn118208O09118Mus musculusPredictionMore>>
1:1 orthologNTN1455083H2QC90Pan troglodytesPredictionMore>>
1:1 orthologA0A4X1V6Z8Sus scrofaPredictionMore>>
1:1 orthologNtn1F1LPC8Rattus norvegicusPredictionMore>>
1:1 orthologntn1a30227O42140Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005604 basement membrane
GO:0005737 cytoplasm
GO:0009887 animal organ morphogenesis
GO:0033564 anterior/posterior axon guidance
GO:0098609 cell-cell adhesion
GO:0061643 chemorepulsion of axon
GO:0016358 dendrite development
GO:0042472 inner ear morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0008045 motor neuron axon guidance
GO:0030517 negative regulation of axon extension
GO:0001764 neuron migration
GO:0007097 nuclear migration
GO:0045773 positive regulation of axon extension
GO:0008284 positive regulation of cell population proliferation
GO:0030334 regulation of cell migration
GO:0051963 regulation of synapse assembly
GO:0009888 tissue development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0424 Laminin EGF-like domain
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR008979 Galactose-bd-like_sf
IPR002049 Laminin_EGF
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008993 TIMP-like_OB-fold

PROSITE

PROSITE ID PROSITE Term
PS01248 EGF_LAM_1
PS50027 EGF_LAM_2
PS51117 LAMININ_NTER
PS50189 NTR

Pfam

Pfam ID Pfam Term
PF00053 Laminin_EGF
PF00055 Laminin_N
PF01759 NTR