| Tag | Content |
|---|---|
| Uniprot ID | O09118; B1ARR0; Q60832; Q9QY50; |
| Entrez ID | 18208 |
| Genbank protein ID | AAA87938.1; EDL10446.1; AAI41295.1; AAD28602.1; AAC52971.1; |
| Genbank nucleotide ID | NM_008744.2 |
| Ensembl protein ID | ENSMUSP00000104314; ENSMUSP00000021284; |
| Ensembl nucleotide ID | ENSMUSG00000020902 |
| Gene name | Netrin-1 |
| Gene symbol | Ntn1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). |
| Sequence | MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF 60 GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNSSDPK KAHPPAFLTD LNNPHNLTCW 120 QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ 180 CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD 240 WVTATDIRVA FSRLHTFGDE NEDDSELARD SYYYAVSDLQ VGGRCKCNGH AARCVRDRDD 300 SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS 360 GRKSGGVCLN CRHNTAGRHC HYCKEGFYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT 420 GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK 480 GKLKMNMKKY CRKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR 540 DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK 600 CKKA 604 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NTN1 | 522767 | F1N0C7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NTN1 | A0A452FGQ4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NTN1 | 9423 | O95631 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Ntn1 | 18208 | O09118 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | NTN1 | 455083 | H2QC90 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A4X1V6Z8 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Ntn1 | F1LPC8 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ntn1a | 30227 | O42140 | Danio rerio | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| NTN1 | rs4791774C>T (increase risk) | GWAS | 31780810 |
| NTN1 | rs11273201 | Genotyping and GWAS | 27033726 |
| NTN1 | rs7406226 | Genotyping and GWAS | 27033726 |
| NTN1 | rs1880646 | Genotyping and GWAS | 27033726 |
| NTN1 | rs1880646G>A | GWAS | 28232668 |
| NTN1 | rs2872615A>G | GWAS | 28232668 |
| NTN1 | haplotype combination rs9788972-rs9915089 | GWAS | 3221112 |
| NTN1 | haplotype combination rs4791774-rs9788972 | GWAS | 3221112 |
| NTN1 | rs11273201A>AACCCAAAACCCAC | GWAS; EMMAX; and TWAS | 33137956 |
| NTN1 | rs4791774 A>G | GWAS and TDT | 30506619 |
| NTN1 | rs9904526 | GWAS and Sanger sequencing | 25704602 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005125 | cytokine activity | ISS |
| GO:0005201 | extracellular matrix structural constituent | RCA |
| GO:0005515 | protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001764 | neuron migration | IMP |
| GO:0002456 | T cell mediated immunity | ISS |
| GO:0006915 | apoptotic process | IEA |
| GO:0006930 | substrate-dependent cell migration, cell extension | ISS |
| GO:0006930 | substrate-dependent cell migration, cell extension | ISO |
| GO:0007097 | nuclear migration | IDA |
| GO:0007265 | Ras protein signal transduction | ISS |
| GO:0007265 | Ras protein signal transduction | ISO |
| GO:0007409 | axonogenesis | IDA |
| GO:0007411 | axon guidance | IMP |
| GO:0007411 | axon guidance | IDA |
| GO:0008045 | motor neuron axon guidance | IBA |
| GO:0008284 | positive regulation of cell population proliferation | IMP |
| GO:0009887 | animal organ morphogenesis | IBA |
| GO:0009888 | tissue development | IBA |
| GO:0016358 | dendrite development | IBA |
| GO:0019724 | B cell mediated immunity | ISS |
| GO:0030334 | regulation of cell migration | IDA |
| GO:0030334 | regulation of cell migration | IMP |
| GO:0030517 | negative regulation of axon extension | IDA |
| GO:0030879 | mammary gland development | IGI |
| GO:0032488 | Cdc42 protein signal transduction | ISS |
| GO:0032488 | Cdc42 protein signal transduction | ISO |
| GO:0033564 | anterior/posterior axon guidance | IMP |
| GO:0042100 | B cell proliferation | ISS |
| GO:0042472 | inner ear morphogenesis | IMP |
| GO:0045773 | positive regulation of axon extension | ISO |
| GO:0045773 | positive regulation of axon extension | IDA |
| GO:0051963 | regulation of synapse assembly | EXP |
| GO:0051963 | regulation of synapse assembly | IDA |
| GO:0051963 | regulation of synapse assembly | IMP |
| GO:0060603 | mammary gland duct morphogenesis | IGI |
| GO:0061643 | chemorepulsion of axon | IDA |
| GO:0098609 | cell-cell adhesion | IGI |
| GO:2000147 | positive regulation of cell motility | ISS |
| GO:2000147 | positive regulation of cell motility | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | ISS |
| GO:0005576 | extracellular region | ISO |
| GO:0005576 | extracellular region | TAS |
| GO:0005604 | basement membrane | IDA |
| GO:0005604 | basement membrane | IBA |
| GO:0005737 | cytoplasm | IDA |
| GO:0031012 | extracellular matrix | ISO |
| GO:0062023 | collagen-containing extracellular matrix | HDA |
| GO:0071944 | cell periphery | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-373752 | Netrin-1 signaling | IEA |
| R-MMU-418885 | DCC mediated attractive signaling | IEA |
| R-MMU-422475 | Axon guidance | IEA |