Gene: WNT10A

Basic information

Tag Content
Uniprot ID H2QJF8; A0A2J8NGC3;
Entrez ID 459952
Genbank protein ID
Genbank nucleotide ID XM_516098.6
Ensembl protein ID ENSPTRP00000022097
Ensembl nucleotide ID ENSPTRG00000012931
Gene name Protein Wnt
Gene symbol WNT10A
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Ligand for members of the frizzled family of seven transmembrane receptors.
Sequence
MGSAHPRPWL RLRPQPQPRP ALWVLLFFLL LLAAAMPRSA PNDILDLRLP PEPVLNANTV 60
CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF RDQRWNCSSL ETRNKIPYES 120
PIFSRGFRES AFAYAIAAAG VVHAVSNACA LGKLKACGCD ASRRGDEEAF RRKLHRLQLD 180
ALQRGKGLSH GVPEHPALPT ASPGLQDSWE WGGCSPDMGF GERFSKDFLD SREPHRDIHA 240
RMRLHNNRVG RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RSRFHRATLI 300
RPHNRNGGQL EPGPAGAPSP APGAPGPRRR ASPADLVYFE KSPDFCEREP RLDSAGTVGR 360
LCNKSSAGSD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC FVVCEECRIT EWVSVCK 417

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologWNT10A537330F1MEW8Bos taurusPredictionMore>>
1:1 orthologWNT10A488528E2RH98Canis lupus familiarisPredictionMore>>
1:1 orthologWNT10A102177945A0A452FQH4Capra hircusPredictionMore>>
1:1 orthologWNT10A80326Q9GZT5CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologWnt10a22409P70701E14.5Mus musculusPredictionMore>>
1:1 orthologWNT10A459952H2QJF8Pan troglodytesPredictionMore>>
1:1 orthologWNT10A100352839G1TAR3Oryctolagus cuniculusPredictionMore>>
1:1 orthologWnt10a316527D3ZRW5Rattus norvegicusPredictionMore>>
1:1 orthologwnt10a30171B0V1G8Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0005109 frizzled binding
GO:0048018 receptor ligand activity
GO:0060070 canonical Wnt signaling pathway
GO:0045165 cell fate commitment
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0031069 hair follicle morphogenesis
GO:0014033 neural crest cell differentiation
GO:0030182 neuron differentiation
GO:0042476 odontogenesis
GO:0010628 positive regulation of gene expression
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0048733 sebaceous gland development
GO:0043586 tongue development
GO:0016055 Wnt signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0272 Extracellular matrix
KW-1185 Reference proteome
KW-0964 Secreted
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR005817 Wnt
IPR013302 Wnt10
IPR043158 Wnt_C
IPR018161 Wnt_CS

PROSITE

PROSITE ID PROSITE Term
PS00246 WNT1

Pfam

Pfam ID Pfam Term
PF00110 wnt