Gene: Wnt10a

Basic information

Tag Content
Uniprot ID P70701
Entrez ID 22409
Genbank protein ID AAB08085.1; AAH14737.1;
Genbank nucleotide ID NM_009518.2
Ensembl protein ID ENSMUSP00000006718
Ensembl nucleotide ID ENSMUSG00000026167
Gene name Protein Wnt-10a
Gene symbol Wnt10a
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage E14.5
Data sources Homology search
Reference
Functional description Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Required for normal expression of KRT9 in foot plant epithelium. Required for normal hair follicle function.
Sequence
MGSAHPRPWL RLPQGPQPRP EFWALLFFLL LLAAAVPRSA PNDILGLRLP PEPVLNANTV 60
CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF RDQRWNCSSL ETRNKVPYES 120
PIFSRGFRES AFAYAIAAAG VVHAVSNACA LGKLKACGCD ASRRGDEEAF RRKLHRLQLD 180
ALQRGKGLSH GVPEHPAILP ASPGLQDSWE WGGCSPDVGF GERFSKDFLD SREPHRDIHA 240
RMRLHNNRVG RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RNRFHRATLI 300
RPHNRNGGQL EPGPAGAPSP APGTPGLRRR ASHSDLVYFE KSPDFCEREP RLDSAGTVGR 360
LCNKSSTGPD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC FVVCEECRIT EWVSVCK 417

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologWNT10A537330F1MEW8Bos taurusPredictionMore>>
1:1 orthologWNT10A488528E2RH98Canis lupus familiarisPredictionMore>>
1:1 orthologWNT10A102177945A0A452FQH4Capra hircusPredictionMore>>
1:1 orthologWNT10A80326Q9GZT5CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologWnt10a22409P70701E14.5Mus musculusPredictionMore>>
1:1 orthologWNT10A459952H2QJF8Pan troglodytesPredictionMore>>
1:1 orthologWNT10A100352839G1TAR3Oryctolagus cuniculusPredictionMore>>
1:1 orthologWnt10a316527D3ZRW5Rattus norvegicusPredictionMore>>
1:1 orthologwnt10a30171B0V1G8Danio rerioPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
WNT10A392C>TPCR-RFLP24957471
WNT10Ars147680216G>A; p.Gly213SerPCR-RFLP31155400

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005102 signaling receptor bindingTAS
GO:0005109 frizzled bindingIBA
GO:0048018 receptor ligand activityISO

GO:Biological Process

GO ID GO Term Evidence
GO:0001942 hair follicle developmentISO
GO:0007165 signal transductionTAS
GO:0007267 cell-cell signalingTAS
GO:0009887 animal organ morphogenesisTAS
GO:0010628 positive regulation of gene expressionIDA
GO:0014033 neural crest cell differentiationIDA
GO:0016055 Wnt signaling pathwayIBA
GO:0030182 neuron differentiationIBA
GO:0031069 hair follicle morphogenesisISO
GO:0042476 odontogenesisISO
GO:0042487 regulation of odontogenesis of dentin-containing toothIDA
GO:0043586 tongue developmentISO
GO:0043588 skin developmentISO
GO:0045165 cell fate commitmentIBA
GO:0048730 epidermis morphogenesisISO
GO:0048733 sebaceous gland developmentISO
GO:0060070 canonical Wnt signaling pathwayISO
GO:0071560 cellular response to transforming growth factor beta stimulusIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005615 extracellular spaceIBA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-195721 Signaling by WNTIEA
R-MMU-3238698 WNT ligand biogenesis and traffickingIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0272 Extracellular matrix
KW-0325 Glycoprotein
KW-0449 Lipoprotein
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR005817 Wnt
IPR013302 Wnt10
IPR043158 Wnt_C
IPR018161 Wnt_CS

PROSITE

PROSITE ID PROSITE Term
PS00246 WNT1

Pfam

Pfam ID Pfam Term
PF00110 wnt