| Tag | Content |
|---|---|
| Uniprot ID | H2QW52; A0A2J8IU76; |
| Entrez ID | 464169 |
| Genbank protein ID | JAA09129.1; JAA36317.1; JAA15241.1; JAA25919.1; |
| Genbank nucleotide ID | XM_016959457.1 |
| Ensembl protein ID | ENSPTRP00000034651 |
| Ensembl nucleotide ID | ENSPTRG00000020235 |
| Gene name | Snail family transcriptional repressor 2 |
| Gene symbol | SNAI2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS GAYSPITVWT 60 TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS GSESPISDEE ERLQSKLSDP 120 HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH CDAQSRKSFS CKYCDKEYVS LGALKMHIRT 180 HTLPCVCKIC GKAFSRPWLL QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK 240 YQCKNCSKTF SRMSLLHKHE ESGCCVAH 268 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SNAI2 | 520631 | Q3MHQ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | F1PTM6 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SNAI2 | 102178744 | A0A452FYL7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 100050060 | F6R5C0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 6591 | O43623 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Snai2 | 20583 | P97469 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SNAI2 | 464169 | H2QW52 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 102162332 | A0A287A115 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 100346095 | G1T2X3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Snai2 | 25554 | O08954 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | snai2 | 494038 | Q5PQY5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000790 | nuclear chromatin |
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0070888 | E-box binding |
| GO:0071364 | cellular response to epidermal growth factor stimulus |
| GO:0035921 | desmosome disassembly |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:2000811 | negative regulation of anoikis |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0032331 | negative regulation of chondrocyte differentiation |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| GO:0010839 | negative regulation of keratinocyte proliferation |
| GO:0010957 | negative regulation of vitamin D biosynthetic process |
| GO:0070563 | negative regulation of vitamin D receptor signaling pathway |
| GO:0014032 | neural crest cell development |
| GO:0007219 | Notch signaling pathway |
| GO:0001649 | osteoblast differentiation |
| GO:0043473 | pigmentation |
| GO:0030335 | positive regulation of cell migration |
| GO:2000810 | regulation of bicellular tight junction assembly |
| GO:0032642 | regulation of chemokine production |
| GO:0045667 | regulation of osteoblast differentiation |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0007605 | sensory perception of sound |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |