| Tag | Content |
|---|---|
| Uniprot ID | O08954; Q8R482; |
| Entrez ID | 25554 |
| Genbank protein ID | AAM19227.1; AAB58706.1; |
| Genbank nucleotide ID | NM_013035.1 |
| Ensembl protein ID | ENSRNOP00000064195 |
| Ensembl nucleotide ID | ENSRNOG00000047699 |
| Gene name | Zinc finger protein SNAI2 |
| Gene symbol | Snai2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). |
| Sequence | MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLCESYPMP VIPKPEILTS GAYSPITVWT 60 SAVPFHSPLP SGLSPLTGYS SSLGRVSPLP SSDTSSKDHS GSESPISDEE ERLQPKLSDP 120 HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH CDAQARKSFS CKYCDKEYVS LGALKMHIRT 180 HTLPCVCKIC GKAFSRPWLL QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK 240 YQCKNCSKTF SRMSLLHKHE ESGCCVAH 268 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SNAI2 | 520631 | Q3MHQ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | F1PTM6 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SNAI2 | 102178744 | A0A452FYL7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 100050060 | F6R5C0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 6591 | O43623 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Snai2 | 20583 | P97469 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SNAI2 | 464169 | H2QW52 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 102162332 | A0A287A115 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 100346095 | G1T2X3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Snai2 | 25554 | O08954 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | snai2 | 494038 | Q5PQY5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0000790 | nuclear chromatin |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0070888 | E-box binding |
| GO:0046872 | metal ion binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0060536 | cartilage morphogenesis |
| GO:0016477 | cell migration |
| GO:0003273 | cell migration involved in endocardial cushion formation |
| GO:0071364 | cellular response to epidermal growth factor stimulus |
| GO:0044344 | cellular response to fibroblast growth factor stimulus |
| GO:0071479 | cellular response to ionizing radiation |
| GO:0035921 | desmosome disassembly |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0060429 | epithelium development |
| GO:2000811 | negative regulation of anoikis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration |
| GO:0032331 | negative regulation of chondrocyte differentiation |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| GO:0010839 | negative regulation of keratinocyte proliferation |
| GO:2000647 | negative regulation of stem cell proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0010957 | negative regulation of vitamin D biosynthetic process |
| GO:0070563 | negative regulation of vitamin D receptor signaling pathway |
| GO:0014032 | neural crest cell development |
| GO:0007219 | Notch signaling pathway |
| GO:0001649 | osteoblast differentiation |
| GO:0043473 | pigmentation |
| GO:0030335 | positive regulation of cell migration |
| GO:0045600 | positive regulation of fat cell differentiation |
| GO:0035066 | positive regulation of histone acetylation |
| GO:2000810 | regulation of bicellular tight junction assembly |
| GO:0060693 | regulation of branching involved in salivary gland morphogenesis |
| GO:0032642 | regulation of chemokine production |
| GO:0045667 | regulation of osteoblast differentiation |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0009314 | response to radiation |
| GO:0060021 | roof of mouth development |
| GO:0007605 | sensory perception of sound |
| GO:0050872 | white fat cell differentiation |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |