| Tag | Content |
|---|---|
| Uniprot ID | P97469; O09096; Q9R211; |
| Entrez ID | 20583 |
| Genbank protein ID | AAH62164.1; AAB38365.1; AAD23913.1; AAB58704.1; |
| Genbank nucleotide ID | NM_011415.2 |
| Ensembl protein ID | ENSMUSP00000023356 |
| Ensembl nucleotide ID | ENSMUSG00000022676 |
| Gene name | Zinc finger protein SNAI2 |
| Gene symbol | Snai2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17376812 |
| Functional description | Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). |
| Sequence | MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYPIP VIPKPEILTS GAYSPITVWT 60 SSAAPLHSPL PSGLSPLTGY SSSLGRVSPP PSSDTSSKDH SGSESPISDE EERLQPKLSD 120 PHAIEAEKFQ CNLCNKTYST FSGLAKHKQL HCDAQSRKSF SCKYCDKEYV SLGALKMHIR 180 THTLPCVCKI CGKAFSRPWL LQGHIRTHTG EKPFSCPHCN RAFADRSNLR AHLQTHSDVK 240 KYQCKNCSKT FSRMSLLHKH EESGCCVAH 269 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SNAI2 | 520631 | Q3MHQ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | F1PTM6 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SNAI2 | 102178744 | A0A452FYL7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 100050060 | F6R5C0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 6591 | O43623 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Snai2 | 20583 | P97469 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SNAI2 | 464169 | H2QW52 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 102162332 | A0A287A115 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SNAI2 | 100346095 | G1T2X3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Snai2 | 25554 | O08954 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | snai2 | 494038 | Q5PQY5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISO |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | ISO |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IGI |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA |
| GO:0003677 | DNA binding | IBA |
| GO:0003682 | chromatin binding | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0043565 | sequence-specific DNA binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GO:0070888 | E-box binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0001649 | osteoblast differentiation | IEA |
| GO:0001837 | epithelial to mesenchymal transition | ISO |
| GO:0001837 | epithelial to mesenchymal transition | IMP |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation | IMP |
| GO:0003273 | cell migration involved in endocardial cushion formation | IMP |
| GO:0006355 | regulation of transcription, DNA-templated | IBA |
| GO:0006929 | substrate-dependent cell migration | IMP |
| GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration | IMP |
| GO:0007219 | Notch signaling pathway | ISS |
| GO:0007219 | Notch signaling pathway | ISO |
| GO:0007605 | sensory perception of sound | ISO |
| GO:0007605 | sensory perception of sound | IMP |
| GO:0009314 | response to radiation | IDA |
| GO:0009314 | response to radiation | IMP |
| GO:0010839 | negative regulation of keratinocyte proliferation | ISO |
| GO:0010957 | negative regulation of vitamin D biosynthetic process | ISO |
| GO:0014032 | neural crest cell development | ISO |
| GO:0016477 | cell migration | IGI |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0032331 | negative regulation of chondrocyte differentiation | ISO |
| GO:0032642 | regulation of chemokine production | ISO |
| GO:0035066 | positive regulation of histone acetylation | IMP |
| GO:0035921 | desmosome disassembly | ISO |
| GO:0035921 | desmosome disassembly | IMP |
| GO:0036120 | cellular response to platelet-derived growth factor stimulus | TAS |
| GO:0042981 | regulation of apoptotic process | IC |
| GO:0043066 | negative regulation of apoptotic process | IGI |
| GO:0043473 | pigmentation | ISO |
| GO:0043473 | pigmentation | IMP |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | ISO |
| GO:0044319 | wound healing, spreading of cells | TAS |
| GO:0045600 | positive regulation of fat cell differentiation | IGI |
| GO:0045600 | positive regulation of fat cell differentiation | IMP |
| GO:0045667 | regulation of osteoblast differentiation | ISO |
| GO:0050872 | white fat cell differentiation | IMP |
| GO:0060021 | roof of mouth development | IGI |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060429 | epithelium development | IMP |
| GO:0060536 | cartilage morphogenesis | IGI |
| GO:0060693 | regulation of branching involved in salivary gland morphogenesis | IMP |
| GO:0070563 | negative regulation of vitamin D receptor signaling pathway | ISO |
| GO:0071364 | cellular response to epidermal growth factor stimulus | ISO |
| GO:0071479 | cellular response to ionizing radiation | IGI |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | ISO |
| GO:1900387 | negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter | ISO |
| GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | ISO |
| GO:2000647 | negative regulation of stem cell proliferation | IMP |
| GO:2000810 | regulation of bicellular tight junction assembly | ISO |
| GO:2000811 | negative regulation of anoikis | ISO |
| GO:2001028 | positive regulation of endothelial cell chemotaxis | IC |
| GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000790 | nuclear chromatin | ISO |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005737 | cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |