Gene: ASS1

Basic information

Tag Content
Uniprot ID H2QY18; A0A2J8NAT8;
Entrez ID 743223
Genbank protein ID JAA39342.1; JAA24783.1; JAA13225.1; JAA03840.1;
Genbank nucleotide ID XM_003951552.2
Ensembl protein ID ENSPTRP00000036742
Ensembl nucleotide ID ENSPTRG00000021473
Gene name Argininosuccinate synthase 1
Gene symbol ASS1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSSKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK ALKLGAKKVF 60
IEDVSKEFVE EFIWPAIQSS ALYEDRYLLG TSLARPCIAR KQVEIAQREG AKYVSHGATG 120
KGNDQVRFEL SCYSLAPHIK VIAPWRMPEF YNRFKGRNDL MEYAKQHGIP IPVTPKNPWS 180
MDENLMHISY EAGILENPKN QAPPGLYTKT QDPAKAPNTP DILEIEFKKG VPVKVTNVKD 240
GTTHQTSLEL FMYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF 300
TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIAK SQERVEGKVQ VSVLKGQVYI 360
LGRESPLSLY NEELVSMNVQ GDYEPTDATG FININSLRLK EYHRLQSKVT AK 412

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologASS1280726P14568Bos taurusPredictionMore>>
1:1 orthologASS1A0A452F1Z3Capra hircusPredictionMore>>
1:1 orthologASS1445P00966CL/PHomo sapiensPublicationMore>>
1:1 orthologAss111898P16460E14.5Mus musculusPredictionMore>>
1:1 orthologASS1743223H2QY18Pan troglodytesPredictionMore>>
1:1 ortholog414411A0A480HLI7Sus scrofaPredictionMore>>
1:1 orthologAss125698P09034Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016597 amino acid binding
GO:0004055 argininosuccinate synthase activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0006526 arginine biosynthetic process
GO:0000053 argininosuccinate metabolic process
GO:0006531 aspartate metabolic process
GO:0071499 cellular response to laminar fluid shear stress
GO:0007623 circadian rhythm
GO:0000052 citrulline metabolic process
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0000050 urea cycle

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold

PROSITE

PROSITE ID PROSITE Term
PS00564 ARGININOSUCCIN_SYN_1
PS00565 ARGININOSUCCIN_SYN_2

Pfam

Pfam ID Pfam Term
PF00764 Arginosuc_synth