Gene: ASS1

Basic information

Tag Content
Uniprot ID P14568; Q3T0A7;
Entrez ID 280726
Genbank protein ID AAI02475.1; AAA30388.1;
Genbank nucleotide ID NM_173892.4
Ensembl protein ID ENSBTAP00000074521; ENSBTAP00000027649;
Ensembl nucleotide ID ENSBTAG00000020747
Gene name Argininosuccinate synthase
Gene symbol ASS1
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
Sequence
MSGKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK ALKLGAKKVF 60
IEDISKEFVE EFIWPAIQSS ALYEDRYLLG TSLARPCIAR KQVEIAQREG AKYVSHGATG 120
KGNDQIRFEL TCYSLAPQIK VIAPWRMPEF YNRFQGRNDL MEYAKQHGIP VPVTPKNPWS 180
MDENLMHISY EAGILENPKN QAPPGLYTKT QDPAKAPNSP DMLEIEFKKG VPVKVTNVGD 240
GTTHSTALEL FLYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF 300
TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIAK SQERVEGKVQ VSVFKGQVYI 360
LGRESPLSLY NEELVSMNVQ GDYEPVDATG FININSLRLK EYHRLQNKVT AK 412

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologASS1280726P14568Bos taurusPredictionMore>>
1:1 orthologASS1A0A452F1Z3Capra hircusPredictionMore>>
1:1 orthologASS1445P00966CL/PHomo sapiensPublicationMore>>
1:1 orthologAss111898P16460E14.5Mus musculusPredictionMore>>
1:1 orthologASS1743223H2QY18Pan troglodytesPredictionMore>>
1:1 ortholog414411A0A480HLI7Sus scrofaPredictionMore>>
1:1 orthologAss125698P09034Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0004055 argininosuccinate synthase activity
GO:0005524 ATP binding
GO:0006526 arginine biosynthetic process
GO:0000053 argininosuccinate metabolic process
GO:0007623 circadian rhythm
GO:0000050 urea cycle

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0028 Amino-acid biosynthesis
KW-0055 Arginine biosynthesis
KW-0067 ATP-binding
KW-0963 Cytoplasm
KW-0436 Ligase
KW-0547 Nucleotide-binding
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0835 Urea cycle

Interpro

InterPro ID InterPro Term
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold

PROSITE

PROSITE ID PROSITE Term
PS00564 ARGININOSUCCIN_SYN_1
PS00565 ARGININOSUCCIN_SYN_2

Pfam

Pfam ID Pfam Term
PF00764 Arginosuc_synth