Gene: Ass1

Basic information

Tag Content
Uniprot ID P09034
Entrez ID 25698
Genbank protein ID AAA40771.1; AAH63146.1; CAA30999.1;
Genbank nucleotide ID NM_013157.3; XM_006233911.3;
Ensembl protein ID ENSRNOP00000012075; ENSRNOP00000076301;
Ensembl nucleotide ID ENSRNOG00000008837
Gene name Argininosuccinate synthase
Gene symbol Ass1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure (PubMed:19491403).
Sequence
MSSKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK ALKLGAKKVF 60
IEDVSKEFVE EFIWPAVQSS ALYEDRYLLG TSLARPCIAR KQVEIAQREG AKYVSHGATG 120
KGNDQVRFEL TCYSLAPQIK VIAPWRMPEF YNRFKGRNDL MEYAKQHGIP IPVTPKSPWS 180
MDENLMHISY EAGILENPKN QAPPGLYTKT QDPAKAPNTP DVLEIEFKKG VPVKVTNVKD 240
GTTHSTSLDL FMYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF 300
TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIDK SQERVEGKVQ VSVFKGQVYI 360
LGRESPLSLY NEELVSMNVQ GDYEPIDATG FININSLRLK EYHRLQSKVT AK 412

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologASS1280726P14568Bos taurusPredictionMore>>
1:1 orthologASS1A0A452F1Z3Capra hircusPredictionMore>>
1:1 orthologASS1445P00966CL/PHomo sapiensPublicationMore>>
1:1 orthologAss111898P16460E14.5Mus musculusPredictionMore>>
1:1 orthologASS1743223H2QY18Pan troglodytesPredictionMore>>
1:1 ortholog414411A0A480HLI7Sus scrofaPredictionMore>>
1:1 orthologAss125698P09034Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0070852 cell body fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005783 endoplasmic reticulum
GO:0005764 lysosome
GO:0005741 mitochondrial outer membrane
GO:0005739 mitochondrion
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0005634 nucleus
GO:0043204 perikaryon
GO:0016597 amino acid binding
GO:0004055 argininosuccinate synthase activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0015643 toxic substance binding
GO:0006953 acute-phase response
GO:0007568 aging
GO:0006526 arginine biosynthetic process
GO:0000053 argininosuccinate metabolic process
GO:0006531 aspartate metabolic process
GO:0071418 cellular response to amine stimulus
GO:0071230 cellular response to amino acid stimulus
GO:0071242 cellular response to ammonium ion
GO:0071320 cellular response to cAMP
GO:0071549 cellular response to dexamethasone stimulus
GO:0071377 cellular response to glucagon stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071499 cellular response to laminar fluid shear stress
GO:0071222 cellular response to lipopolysaccharide
GO:0071400 cellular response to oleic acid
GO:0071356 cellular response to tumor necrosis factor
GO:0007623 circadian rhythm
GO:0000052 citrulline metabolic process
GO:0060539 diaphragm development
GO:0001822 kidney development
GO:0001889 liver development
GO:0007494 midgut development
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0014075 response to amine
GO:0043200 response to amino acid
GO:0042493 response to drug
GO:0032355 response to estradiol
GO:0070542 response to fatty acid
GO:0051384 response to glucocorticoid
GO:0060416 response to growth hormone
GO:0032496 response to lipopolysaccharide
GO:0010046 response to mycotoxin
GO:0007584 response to nutrient
GO:0043434 response to peptide hormone
GO:0048545 response to steroid hormone
GO:0009636 response to toxic substance
GO:0010043 response to zinc ion
GO:0000050 urea cycle

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0028 Amino-acid biosynthesis
KW-0055 Arginine biosynthesis
KW-0067 ATP-binding
KW-0963 Cytoplasm
KW-0436 Ligase
KW-0547 Nucleotide-binding
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0835 Urea cycle

Interpro

InterPro ID InterPro Term
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold

PROSITE

PROSITE ID PROSITE Term
PS00564 ARGININOSUCCIN_SYN_1
PS00565 ARGININOSUCCIN_SYN_2

Pfam

Pfam ID Pfam Term
PF00764 Arginosuc_synth