| Tag | Content |
|---|---|
| Uniprot ID | P09034 |
| Entrez ID | 25698 |
| Genbank protein ID | AAA40771.1; AAH63146.1; CAA30999.1; |
| Genbank nucleotide ID | NM_013157.3; XM_006233911.3; |
| Ensembl protein ID | ENSRNOP00000012075; ENSRNOP00000076301; |
| Ensembl nucleotide ID | ENSRNOG00000008837 |
| Gene name | Argininosuccinate synthase |
| Gene symbol | Ass1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure (PubMed:19491403). |
| Sequence | MSSKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK ALKLGAKKVF 60 IEDVSKEFVE EFIWPAVQSS ALYEDRYLLG TSLARPCIAR KQVEIAQREG AKYVSHGATG 120 KGNDQVRFEL TCYSLAPQIK VIAPWRMPEF YNRFKGRNDL MEYAKQHGIP IPVTPKSPWS 180 MDENLMHISY EAGILENPKN QAPPGLYTKT QDPAKAPNTP DVLEIEFKKG VPVKVTNVKD 240 GTTHSTSLDL FMYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF 300 TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIDK SQERVEGKVQ VSVFKGQVYI 360 LGRESPLSLY NEELVSMNVQ GDYEPIDATG FININSLRLK EYHRLQSKVT AK 412 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.