Gene: PHYH

Basic information

Tag Content
Uniprot ID O18778; Q3T0C0;
Entrez ID 281400
Genbank protein ID AAB65800.1; AAI02461.1;
Genbank nucleotide ID NM_174142.2
Ensembl protein ID ENSBTAP00000010126
Ensembl nucleotide ID ENSBTAG00000007700
Gene name Phytanoyl-CoA dioxygenase, peroxisomal
Gene symbol PHYH
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono- branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity).
Sequence
MDRNRASARL TVLLRHLGCR SAGTIIAHHT SGVGSLASFH PQQFQYTREN NVLSLEQRKF 60
YEENGFLVIK NLVSDADIQR FRNEFERICR KEVKPLGLSV MRDVTITKSE YVPSEKVVSK 120
VQDFQEDEEL FRYCTLPEIL KYVECFTGPN IMAMHTMLIN KPPDSGKKTS RHPLHQDLHY 180
FPFRPSNSIV CAWTAMEHID RNNGCLVVLP GTHKGPLQPH DYPQWEGGVN IMFHGIQDYD 240
KNNARVHLVM EKGDTVFFHP LLIHGSGRNK SQGFRKAISC HFADANCHYI DVEGTSQENI 300
EKEVVDIVRK KYGFKDVTLK DVWTFRGRVV KGERINL 337

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPHYH281400O18778Bos taurusPredictionMore>>
1:1 orthologPHYH102179212A0A452FPA5Capra hircusPredictionMore>>
1:1 orthologPHYH5264O14832Homo sapiensPublicationMore>>
1:1 orthologPhyh16922O35386Mus musculusPredictionMore>>
1:1 orthologPHYH450310H2Q1M5Pan troglodytesPredictionMore>>
1:1 orthologPHYHA0A286ZZ49Sus scrofaPredictionMore>>
1:1 orthologPhyh114209P57093Rattus norvegicusPredictionMore>>
1:1 orthologphyhE7FCS1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005777 peroxisome
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
GO:0048244 phytanoyl-CoA dioxygenase activity
GO:0001561 fatty acid alpha-oxidation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0223 Dioxygenase
KW-0408 Iron
KW-0479 Metal-binding
KW-0560 Oxidoreductase
KW-0576 Peroxisome
KW-1185 Reference proteome
KW-0809 Transit peptide
KW-0847 Vitamin C

Interpro

InterPro ID InterPro Term
IPR008775 Phytyl_CoA_dOase

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF05721 PhyH