| Tag | Content |
|---|---|
| Uniprot ID | P57093; Q9QY64; |
| Entrez ID | 114209 |
| Genbank protein ID | AAF15971.1; AAH86573.1; |
| Genbank nucleotide ID | NM_053674.1 |
| Ensembl protein ID | ENSRNOP00000024362 |
| Ensembl nucleotide ID | ENSRNOG00000018044 |
| Gene name | Phytanoyl-CoA dioxygenase, peroxisomal |
| Gene symbol | Phyh |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the 2-hydroxylation of racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA (PubMed:10588950, PubMed:10744784). Shows activity also towards a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity). |
| Sequence | MDYTRAGARL QVLLGHLGRP SALQIVAHPV SGPASPANFC PEQFQYTLDN NVLSLEQRKF 60 YEENGFLVIK NLVSDDDIQR FRAEFERICR KEVKPPGMTV MKDVAIAKQG YAPSERVVTK 120 IQDFQQNEEL FRYCALPQIV KYVECFTGPN IMAMHTMLIN KPPDSGKKTS RHPLHQDLHF 180 FPFRPSNLIV CAWTAMEHID RNNGCLVVLP GTHKGPLKPH DYPKWEGGVN KMYHGIQDYD 240 PDSPRVHLVM EKGDTVFFHP LLIHGSGRNR TQGFRKAISC HYGSSDCKYI SVKGTSQENI 300 AREVIEIAEK RYGVQGALDF EDTWKFRCRL VKGERINL 338 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.