| Tag | Content |
|---|---|
| Uniprot ID | O35386; O08527; |
| Entrez ID | 16922 |
| Genbank protein ID | BAA19003.1; AAH02018.1; AAB81835.1; |
| Genbank nucleotide ID | NM_010726.2 |
| Ensembl protein ID | ENSMUSP00000027975 |
| Ensembl nucleotide ID | ENSMUSG00000026664 |
| Gene name | Phytanoyl-CoA dioxygenase, peroxisomal |
| Gene symbol | Phyh |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity). |
| Sequence | MNLTRAGARL QVLLGHLGRP SAPTIVAQPV SGLASPASFQ PEQFQYTLDN NVLTLEQRKF 60 YEENGFLVIK NLVSDDDIQR FRAEFERICR EEVKPPGIVI MRDVALAKQD YMPSDRMVSK 120 IQDFQEDEEL FRYCLLPEIL KYVECFTGPN IMALHGMLIN KPPDVGKKTS RHPLHQDLHY 180 FPFRPSNLIV CAWTAMEHID RNNGCLVVLP GTHKGTLKPH DYPKWEGGVN KMYHGIQDYD 240 PNSPRVHLVM EKGDTVFFHP LLIHGSGRNK TQGFRKAISC HFGSSDCQCI DVSGTSQENI 300 AREVVEMAEK KYGFQGVMDF KDTWIFRSRL VKGERINI 338 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PHYH | 281400 | O18778 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PHYH | 102179212 | A0A452FPA5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PHYH | 5264 | O14832 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Phyh | 16922 | O35386 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | PHYH | 450310 | H2Q1M5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PHYH | A0A286ZZ49 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Phyh | 114209 | P57093 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | phyh | E7FCS1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003824 | catalytic activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0008198 | ferrous iron binding | ISO |
| GO:0031406 | carboxylic acid binding | ISO |
| GO:0031418 | L-ascorbic acid binding | IEA |
| GO:0048037 | cofactor binding | ISO |
| GO:0048244 | phytanoyl-CoA dioxygenase activity | ISO |
| GO:0048244 | phytanoyl-CoA dioxygenase activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001561 | fatty acid alpha-oxidation | ISO |
| GO:0001561 | fatty acid alpha-oxidation | IDA |
| GO:0001561 | fatty acid alpha-oxidation | IBA |
| GO:0006103 | 2-oxoglutarate metabolic process | ISO |
| GO:0006720 | isoprenoid metabolic process | ISO |
| GO:0019606 | 2-oxobutyrate catabolic process | ISO |
| GO:0097089 | methyl-branched fatty acid metabolic process | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005739 | mitochondrion | ISO |
| GO:0005739 | mitochondrion | HDA |
| GO:0005777 | peroxisome | ISO |
| GO:0005777 | peroxisome | TAS |
| GO:0005782 | peroxisomal matrix | TAS |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-389599 | Alpha-oxidation of phytanate | IEA |
| R-MMU-390918 | Peroxisomal lipid metabolism | IEA |
| R-MMU-556833 | Metabolism of lipids | IEA |
| R-MMU-8978868 | Fatty acid metabolism | IEA |
| R-MMU-9033241 | Peroxisomal protein import | IEA |
| R-MMU-9609507 | Protein localization | IEA |
| InterPro ID | InterPro Term |
|---|---|
| IPR008775 | Phytyl_CoA_dOase |
| Pfam ID | Pfam Term |
|---|---|
| PF05721 | PhyH |