| Tag | Content |
|---|---|
| Uniprot ID | O35468; Q8VI90; |
| Entrez ID | 22412 |
| Genbank protein ID | BAB83866.1; AAL82385.1; AAC39950.1; |
| Genbank nucleotide ID | NM_011719.4 |
| Ensembl protein ID | ENSMUSP00000018630 |
| Ensembl nucleotide ID | ENSMUSG00000018486 |
| Gene name | Protein Wnt-9b |
| Gene symbol | Wnt9b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CLP,CLO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21982646; 22461561; 16998816; |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:22461561, PubMed:16054034, PubMed:17537789). Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males (PubMed:16054034). Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis (PubMed:16054034, PubMed:17537789). Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts (PubMed:16054034). Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (PubMed:16054034, PubMed:22461561, PubMed:25257647). |
| Sequence | MRPAPALALA ALCLLVLPAA AAAAAYFGLT GREVLTPFPG LGTAAAPAQA GAHLKQCDLL 60 KLSRRQKQLC RREPGLAETL RDAAHLGLLE CQFQFRQERW NCSLEGRTGL LQRGFKETAF 120 LYAVSAAALT HALARACSAG RMERCTCDDS PGLESRQAWQ WGVCGDNLKY STKFLSNFLG 180 PKRGSKDLRA RADAHNTHVG IKAVKSGLRT TCKCHGVSGS CAVRTCWKQL SPFRETGQVL 240 KLRYDTAVKV SSATNEALGR LELWAPAKPG GPAKGLAPRP GDLVYMEDSP SFCRPSKYSP 300 GTAGRVCSRD SSCSSLCCGR GYDTQSRMVV FSCHCQVQWC CYVECQQCAQ QELVYTCKR 359 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT9B | 490919 | J9P198 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WNT9B | A0A452GA54 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | WNT9B | 7484 | O14905 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Wnt9b | 22412 | O35468 | CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WNT9B | A0A287BJB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Wnt9b | 303586 | D3ZFS0 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wnt9b | 565677 | B6V3E2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | IPI |
| GO:0005102 | signaling receptor binding | TAS |
| GO:0005109 | frizzled binding | IBA |
| GO:0039706 | co-receptor binding | IPI |
| GO:0048018 | receptor ligand activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001658 | branching involved in ureteric bud morphogenesis | IGI |
| GO:0001658 | branching involved in ureteric bud morphogenesis | IMP |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001822 | kidney development | IMP |
| GO:0001932 | regulation of protein phosphorylation | IMP |
| GO:0003339 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | IDA |
| GO:0003339 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | IMP |
| GO:0007165 | signal transduction | TAS |
| GO:0007267 | cell-cell signaling | TAS |
| GO:0009267 | cellular response to starvation | IEP |
| GO:0009786 | regulation of asymmetric cell division | IMP |
| GO:0009887 | animal organ morphogenesis | TAS |
| GO:0016055 | Wnt signaling pathway | IMP |
| GO:0016055 | Wnt signaling pathway | IBA |
| GO:0030182 | neuron differentiation | IBA |
| GO:0030539 | male genitalia development | IMP |
| GO:0035150 | regulation of tube size | IMP |
| GO:0043085 | positive regulation of catalytic activity | IMP |
| GO:0045165 | cell fate commitment | IBA |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IMP |
| GO:0048754 | branching morphogenesis of an epithelial tube | IMP |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060070 | canonical Wnt signaling pathway | ISO |
| GO:0060070 | canonical Wnt signaling pathway | IGI |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IMP |
| GO:0060993 | kidney morphogenesis | IMP |
| GO:0061038 | uterus morphogenesis | IMP |
| GO:0072003 | kidney rudiment formation | IMP |
| GO:0072038 | mesenchymal stem cell maintenance involved in nephron morphogenesis | IMP |
| GO:0072044 | collecting duct development | IMP |
| GO:0072046 | establishment of planar polarity involved in nephron morphogenesis | IMP |
| GO:0072078 | nephron tubule morphogenesis | IMP |
| GO:0072164 | mesonephric tubule development | IMP |
| GO:0072164 | mesonephric tubule development | IGI |
| GO:0072170 | metanephric tubule development | IMP |
| GO:0072174 | metanephric tubule formation | IMP |
| GO:0072181 | mesonephric duct formation | IMP |
| GO:1902455 | negative regulation of stem cell population maintenance | ISO |
| GO:1904948 | midbrain dopaminergic neuron differentiation | ISO |
| GO:1905438 | non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IBA |
| GO:1990851 | Wnt-Frizzled-LRP5/6 complex | IC |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-3238698 | WNT ligand biogenesis and trafficking | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |