| Tag | Content |
|---|---|
| Uniprot ID | O35468; Q8VI90; |
| Entrez ID | 22412 |
| Genbank protein ID | BAB83866.1; AAL82385.1; AAC39950.1; |
| Genbank nucleotide ID | NM_011719.4 |
| Ensembl protein ID | ENSMUSP00000018630 |
| Ensembl nucleotide ID | ENSMUSG00000018486 |
| Gene name | Protein Wnt-9b |
| Gene symbol | Wnt9b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CLP,CLO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21982646; 22461561; 16998816; |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:22461561, PubMed:16054034, PubMed:17537789). Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males (PubMed:16054034). Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis (PubMed:16054034, PubMed:17537789). Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts (PubMed:16054034). Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (PubMed:16054034, PubMed:22461561, PubMed:25257647). |
| Sequence | MRPAPALALA ALCLLVLPAA AAAAAYFGLT GREVLTPFPG LGTAAAPAQA GAHLKQCDLL 60 KLSRRQKQLC RREPGLAETL RDAAHLGLLE CQFQFRQERW NCSLEGRTGL LQRGFKETAF 120 LYAVSAAALT HALARACSAG RMERCTCDDS PGLESRQAWQ WGVCGDNLKY STKFLSNFLG 180 PKRGSKDLRA RADAHNTHVG IKAVKSGLRT TCKCHGVSGS CAVRTCWKQL SPFRETGQVL 240 KLRYDTAVKV SSATNEALGR LELWAPAKPG GPAKGLAPRP GDLVYMEDSP SFCRPSKYSP 300 GTAGRVCSRD SSCSSLCCGR GYDTQSRMVV FSCHCQVQWC CYVECQQCAQ QELVYTCKR 359 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
