| Tag | Content |
|---|---|
| Uniprot ID | P00184; Q61455; |
| Entrez ID | 13076 |
| Genbank protein ID | AAA39868.1; AAA37507.1; CAA25836.1; CAA68277.1; AAA37506.1; BAB23734.1; |
| Genbank nucleotide ID | NM_001136059.2; XM_006510810.3; NM_009992.4; |
| Ensembl protein ID | ENSMUSP00000150277; ENSMUSP00000034865; |
| Ensembl nucleotide ID | ENSMUSG00000032315 |
| Gene name | Cytochrome P450 1A1 |
| Gene symbol | Cyp1a1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | E12.4, E12.6, E12.5, E13.3, E12.8, E14.3 |
| Data sources | Homology search |
| Reference | |
| Functional description | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). |
| Sequence | MPSMYGLPAF VSATELLLAV TVFCLGFWVV RATRTWVPKG LKTPPGPWGL PFIGHMLTVG 60 KNPHLSLTRL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL VRQGDDFKGR PDLYSFTLIT 120 NGKSMTFNPD SGPVWAARRR LAQNALKSFS IASDPTSASS CYLEEHVSKE ANYLVSKLQK 180 VMAEVGHFDP YKYLVVSVAN VICAICFGQR YDHDDQELLS IVNLSNEFGE VTGSGYPADF 240 IPVLRYLPNS SLDAFKDLND KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRKLDE 300 NANVQLSDDK VITIVLDLFG AGFDTVTTAI SWSLMYLVTN PRVQRKIQEE LDTVIGRDRQ 360 PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTTRDTSL NGFYIPKGCC VFVNQWQVNH 420 DRELWGDPNE FRPERFLTPS GTLDKRLSEK VTLFGLGKRK CIGETIGRSE VFLFLAILLQ 480 QIEFKVSPGE KVDMTPTYGL TLKHARCEHF QVQMRSSGPQ HLQA 524 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP1A1 | A0A452G3V1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | CYP1A1 | 1543 | P04798 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Cyp1a1 | 13076 | P00184 | E12.4, E12.6, E12.5, E13.3, E12.8, E14.3 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | CYP1A1 | 453744 | A0A2J8KRU7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CYP1A1 | 403103 | Q8SQ69 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | CYP1A1 | 100328613 | P05176 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Cyp1a1 | 24296 | P00185 | Rattus norvegicus | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| CYP1A1 | rs464621; c.3801T>C | Genotyping | 17160896 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003824 | catalytic activity | ISO |
| GO:0004497 | monooxygenase activity | ISO |
| GO:0004497 | monooxygenase activity | IDA |
| GO:0004497 | monooxygenase activity | IBA |
| GO:0005506 | iron ion binding | IEA |
| GO:0008391 | arachidonic acid monooxygenase activity | ISO |
| GO:0008395 | steroid hydroxylase activity | ISO |
| GO:0016491 | oxidoreductase activity | ISO |
| GO:0016679 | oxidoreductase activity, acting on diphenols and related substances as donors | ISO |
| GO:0016711 | flavonoid 3'-monooxygenase activity | ISO |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | IDA |
| GO:0016829 | lyase activity | IEA |
| GO:0019899 | enzyme binding | ISO |
| GO:0020037 | heme binding | IEA |
| GO:0030544 | Hsp70 protein binding | ISS |
| GO:0030544 | Hsp70 protein binding | ISO |
| GO:0032451 | demethylase activity | ISO |
| GO:0051879 | Hsp90 protein binding | ISS |
| GO:0051879 | Hsp90 protein binding | ISO |
| GO:0070330 | aromatase activity | IEA |
| GO:0070576 | vitamin D 24-hydroxylase activity | ISO |
| GO:0101020 | estrogen 16-alpha-hydroxylase activity | ISS |
| GO:0101020 | estrogen 16-alpha-hydroxylase activity | ISO |
| GO:0101021 | estrogen 2-hydroxylase activity | ISS |
| GO:0101021 | estrogen 2-hydroxylase activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001666 | response to hypoxia | IEA |
| GO:0002933 | lipid hydroxylation | ISO |
| GO:0006631 | fatty acid metabolic process | IEA |
| GO:0006631 | fatty acid metabolic process | ISO |
| GO:0006694 | steroid biosynthetic process | IEA |
| GO:0006778 | porphyrin-containing compound metabolic process | ISO |
| GO:0007568 | aging | IEA |
| GO:0008202 | steroid metabolic process | ISO |
| GO:0008210 | estrogen metabolic process | ISS |
| GO:0008210 | estrogen metabolic process | ISO |
| GO:0008283 | cell population proliferation | IEA |
| GO:0009308 | amine metabolic process | IMP |
| GO:0009404 | toxin metabolic process | IMP |
| GO:0009611 | response to wounding | IEA |
| GO:0009615 | response to virus | IEA |
| GO:0009624 | response to nematode | IEA |
| GO:0009635 | response to herbicide | IEA |
| GO:0009636 | response to toxic substance | IMP |
| GO:0009804 | coumarin metabolic process | ISO |
| GO:0009812 | flavonoid metabolic process | ISO |
| GO:0010041 | response to iron(III) ion | IEA |
| GO:0017143 | insecticide metabolic process | ISO |
| GO:0017144 | drug metabolic process | ISO |
| GO:0019341 | dibenzo-p-dioxin catabolic process | ISO |
| GO:0032094 | response to food | IEA |
| GO:0032496 | response to lipopolysaccharide | IEA |
| GO:0033189 | response to vitamin A | IEA |
| GO:0035902 | response to immobilization stress | IEA |
| GO:0042493 | response to drug | IEA |
| GO:0042572 | retinol metabolic process | ISS |
| GO:0042572 | retinol metabolic process | IEA |
| GO:0042572 | retinol metabolic process | ISO |
| GO:0042904 | 9-cis-retinoic acid biosynthetic process | ISO |
| GO:0043010 | camera-type eye development | IEA |
| GO:0046483 | heterocycle metabolic process | IMP |
| GO:0046677 | response to antibiotic | IEA |
| GO:0046685 | response to arsenic-containing substance | IEA |
| GO:0048565 | digestive tract development | IEA |
| GO:0050665 | hydrogen peroxide biosynthetic process | IMP |
| GO:0055093 | response to hyperoxia | IEA |
| GO:0055114 | oxidation-reduction process | ISO |
| GO:0060137 | maternal process involved in parturition | IEA |
| GO:0070365 | hepatocyte differentiation | IEA |
| GO:0070988 | demethylation | IEA |
| GO:0071280 | cellular response to copper ion | IEA |
| GO:0071407 | cellular response to organic cyclic compound | ISO |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | ISO |
| GO:0018894 | dibenzo-p-dioxin metabolic process | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | ISO |
| GO:0005739 | mitochondrion | ISO |
| GO:0005743 | mitochondrial inner membrane | ISS |
| GO:0005743 | mitochondrial inner membrane | ISO |
| GO:0005789 | endoplasmic reticulum membrane | IEA |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0043231 | intracellular membrane-bounded organelle | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-211859 | Biological oxidations | IEA |
| R-MMU-211897 | Cytochrome P450 - arranged by substrate type | IEA |
| R-MMU-211945 | Phase I - Functionalization of compounds | IEA |
| R-MMU-211981 | Xenobiotics | IEA |
| R-MMU-2142670 | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | IEA |
| R-MMU-2142753 | Arachidonic acid metabolism | IEA |
| R-MMU-2142816 | Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) | IEA |
| R-MMU-556833 | Metabolism of lipids | IEA |
| R-MMU-8978868 | Fatty acid metabolism | IEA |
| R-MMU-9018677 | Biosynthesis of DHA-derived SPMs | IEA |
| R-MMU-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | IEA |
| R-MMU-9018681 | Biosynthesis of protectins | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0963 | Cytoplasm |
| KW-0903 | Direct protein sequencing |
| KW-0256 | Endoplasmic reticulum |
| KW-0325 | Glycoprotein |
| KW-0349 | Heme |
| KW-0408 | Iron |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0456 | Lyase |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0492 | Microsome |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0503 | Monooxygenase |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |