| Tag | Content |
|---|---|
| Uniprot ID | P00185 |
| Entrez ID | 24296 |
| Genbank protein ID | AAA41025.1; CAA25153.1; AAA41027.1; |
| Genbank nucleotide ID | NM_012540.2; XM_006243150.2; |
| Ensembl protein ID | ENSRNOP00000026473 |
| Ensembl nucleotide ID | ENSRNOG00000019500 |
| Gene name | Cytochrome P450 1A1 |
| Gene symbol | Cyp1a1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions (By similarity). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (By similarity). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (By similarity). |
| Sequence | MPSVYGFPAF TSATELLLAV TTFCLGFWVV RVTRTWVPKG LKSPPGPWGL PFIGHVLTLG 60 KNPHLSLTKL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL VKQGDDFKGR PDLYSFTLIA 120 NGQSMTFNPD SGPLWAARRR LAQNALKSFS IASDPTLASS CYLEEHVSKE AEYLISKFQK 180 LMAEVGHFDP FKYLVVSVAN VICAICFGRR YDHDDQELLS IVNLSNEFGE VTGSGYPADF 240 IPILRYLPNS SLDAFKDLNK KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRRLDE 300 NANVQLSDDK VITIVFDLFG AGFDTITTAI SWSLMYLVTN PRIQRKIQEE LDTVIGRDRQ 360 PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTIRDTSL NGFYIPKGHC VFVNQWQVNH 420 DQELWGDPNE FRPERFLTSS GTLDKHLSEK VILFGLGKRK CIGETIGRLE VFLFLAILLQ 480 QMEFNVSPGE KVDMTPAYGL TLKHARCEHF QVQMRSSGPQ HLQA 524 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CYP1A1 | A0A452G3V1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | CYP1A1 | 1543 | P04798 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Cyp1a1 | 13076 | P00184 | E12.4, E12.6, E12.5, E13.3, E12.8, E14.3 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | CYP1A1 | 453744 | A0A2J8KRU7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CYP1A1 | 403103 | Q8SQ69 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | CYP1A1 | 100328613 | P05176 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Cyp1a1 | 24296 | P00185 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0005743 | mitochondrial inner membrane |
| GO:0005739 | mitochondrion |
| GO:0008391 | arachidonic acid monooxygenase activity |
| GO:0070330 | aromatase activity |
| GO:0003824 | catalytic activity |
| GO:0032451 | demethylase activity |
| GO:0019899 | enzyme binding |
| GO:0101020 | estrogen 16-alpha-hydroxylase activity |
| GO:0101021 | estrogen 2-hydroxylase activity |
| GO:0016711 | flavonoid 3'-monooxygenase activity |
| GO:0020037 | heme binding |
| GO:0030544 | Hsp70 protein binding |
| GO:0051879 | Hsp90 protein binding |
| GO:0005506 | iron ion binding |
| GO:0016829 | lyase activity |
| GO:0004497 | monooxygenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0016679 | oxidoreductase activity, acting on diphenols and related substances as donors |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO:0008395 | steroid hydroxylase activity |
| GO:0070576 | vitamin D 24-hydroxylase activity |
| GO:0042904 | 9-cis-retinoic acid biosynthetic process |
| GO:0007568 | aging |
| GO:0009308 | amine metabolic process |
| GO:0043010 | camera-type eye development |
| GO:0008283 | cell population proliferation |
| GO:0071280 | cellular response to copper ion |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0009804 | coumarin metabolic process |
| GO:0032502 | developmental process |
| GO:0019341 | dibenzo-p-dioxin catabolic process |
| GO:0018894 | dibenzo-p-dioxin metabolic process |
| GO:0048565 | digestive tract development |
| GO:0017144 | drug metabolic process |
| GO:0008210 | estrogen metabolic process |
| GO:0006631 | fatty acid metabolic process |
| GO:0009812 | flavonoid metabolic process |
| GO:0070365 | hepatocyte differentiation |
| GO:0046483 | heterocycle metabolic process |
| GO:0050665 | hydrogen peroxide biosynthetic process |
| GO:0017143 | insecticide metabolic process |
| GO:0002933 | lipid hydroxylation |
| GO:0001889 | liver development |
| GO:0060137 | maternal process involved in parturition |
| GO:0055114 | oxidation-reduction process |
| GO:0006778 | porphyrin-containing compound metabolic process |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| GO:0046677 | response to antibiotic |
| GO:0046685 | response to arsenic-containing substance |
| GO:0042493 | response to drug |
| GO:0032094 | response to food |
| GO:0009635 | response to herbicide |
| GO:0055093 | response to hyperoxia |
| GO:0001666 | response to hypoxia |
| GO:0035902 | response to immobilization stress |
| GO:0010041 | response to iron(III) ion |
| GO:0032496 | response to lipopolysaccharide |
| GO:0009624 | response to nematode |
| GO:0014070 | response to organic cyclic compound |
| GO:0010033 | response to organic substance |
| GO:0009636 | response to toxic substance |
| GO:0009615 | response to virus |
| GO:0033189 | response to vitamin A |
| GO:0009611 | response to wounding |
| GO:0042572 | retinol metabolic process |
| GO:0006694 | steroid biosynthetic process |
| GO:0008202 | steroid metabolic process |
| GO:0009404 | toxin metabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0963 | Cytoplasm |
| KW-0903 | Direct protein sequencing |
| KW-0256 | Endoplasmic reticulum |
| KW-0325 | Glycoprotein |
| KW-0349 | Heme |
| KW-0408 | Iron |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0456 | Lyase |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0492 | Microsome |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0503 | Monooxygenase |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00086 | CYTOCHROME_P450 |
| Pfam ID | Pfam Term |
|---|---|
| PF00067 | p450 |