| Tag | Content |
|---|---|
| Uniprot ID | P01134; Q63749; |
| Entrez ID | 24827 |
| Genbank protein ID | AAA42234.1; AAA42233.1; CAA26036.1; |
| Genbank nucleotide ID | NM_012671.2 |
| Ensembl protein ID | ENSRNOP00000054248 |
| Ensembl nucleotide ID | ENSRNOG00000016182 |
| Gene name | Protransforming growth factor alpha |
| Gene symbol | Tgfa |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
| Sequence | MVPAAGQLAL LALGILVAVC QALENSTSPL SDSPVAAAVV SHFNKCPDSH TQYCFHGTCR 60 FLVQEEKPAC VCHSGYVGVR CEHADLLAVV AASQKKQAIT ALVVVSIVAL AVLIITCVLI 120 HCCQVRKHCE WCRALVCRHE KPSALLKGRT ACCHSETVV 159 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFA | 7039 | P01135 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tgfa | 21802 | P48030 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TGFA | H2QI26 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TGFA | F1SLD3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tgfa | 24827 | P01134 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfa | I3ISP4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016323 | basolateral plasma membrane |
| GO:0009986 | cell surface |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005615 | extracellular space |
| GO:0005887 | integral component of plasma membrane |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0005154 | epidermal growth factor receptor binding |
| GO:0008083 | growth factor activity |
| GO:0000187 | activation of MAPK activity |
| GO:0001525 | angiogenesis |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0072574 | hepatocyte proliferation |
| GO:0060749 | mammary gland alveolus development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0048523 | negative regulation of cellular process |
| GO:0051781 | positive regulation of cell division |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0045840 | positive regulation of mitotic nuclear division |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0042493 | response to drug |
| GO:0042060 | wound healing |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0245 | EGF-like domain |
| KW-0325 | Glycoprotein |
| KW-0339 | Growth factor |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0497 | Mitogen |
| KW-0564 | Palmitate |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |