| Tag | Content |
|---|---|
| Uniprot ID | P48030 |
| Entrez ID | 21802 |
| Genbank protein ID | AAB50554.1; AAB50553.1; AAA40481.1; |
| Genbank nucleotide ID | NM_031199.4 |
| Ensembl protein ID | ENSMUSP00000032066 |
| Ensembl nucleotide ID | ENSMUSG00000029999 |
| Gene name | Protransforming growth factor alpha |
| Gene symbol | Tgfa |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
| Sequence | MVPATGQLAL LALGILLAVC QALENSTSPL SDSPVAAAVV SHFNKCPDSH TQYCFHGTCR 60 FLVQEEKPAC VCHSGYVGVR CEHADLLAVV AASQKKQAIT ALVVVSIVAL AVLIITCVLI 120 HCCQLRKHCE WCRALVCRHE KPSALLKGRT ACCHSETVV 159 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFA | 7039 | P01135 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tgfa | 21802 | P48030 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TGFA | H2QI26 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TGFA | F1SLD3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tgfa | 24827 | P01134 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfa | I3ISP4 | Danio rerio | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| TGFA | rs11466297A> C | Genotyping;PCR-RFLP | 26605011 |
| TGFA | rs3771497T>G | Genotyping; TDT | 24805869 |
| TGFA | rs3821261T>G | Genotyping;TDT | 19444471 |
| TGFA | rs3771475A>G | Genotyping;TDT | 19444471 |
| TGFA | rs2902345 | TaqMan | 23029012 |
| TGFA | rs3771494T>C | PCR | 23940636 |
| TGFA | rs3771523G>A; c.3822G>A | PCR | 23940636 |
| TGFA | rs11466285T>C; c.3851T>C | PCR | 23940636 |
| TGFA | rs7605323T>C | Genotyping | 21462296 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005154 | epidermal growth factor receptor binding | ISO |
| GO:0005154 | epidermal growth factor receptor binding | ISS |
| GO:0005154 | epidermal growth factor receptor binding | IBA |
| GO:0005154 | epidermal growth factor receptor binding | IDA |
| GO:0005515 | protein binding | IDA |
| GO:0008083 | growth factor activity | ISS |
| GO:0008083 | growth factor activity | ISO |
| GO:0008083 | growth factor activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000187 | activation of MAPK activity | ISS |
| GO:0000187 | activation of MAPK activity | ISO |
| GO:0000187 | activation of MAPK activity | IBA |
| GO:0001525 | angiogenesis | IDA |
| GO:0007173 | epidermal growth factor receptor signaling pathway | ISO |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IBA |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IDA |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008284 | positive regulation of cell population proliferation | IBA |
| GO:0008284 | positive regulation of cell population proliferation | IDA |
| GO:0042060 | wound healing | IEA |
| GO:0042493 | response to drug | IEA |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | ISS |
| GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | ISO |
| GO:0045840 | positive regulation of mitotic nuclear division | ISS |
| GO:0045840 | positive regulation of mitotic nuclear division | ISO |
| GO:0048523 | negative regulation of cellular process | ISO |
| GO:0050679 | positive regulation of epithelial cell proliferation | ISS |
| GO:0050679 | positive regulation of epithelial cell proliferation | ISO |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | IDA |
| GO:0051781 | positive regulation of cell division | IEA |
| GO:0060749 | mammary gland alveolus development | IGI |
| GO:0072574 | hepatocyte proliferation | ISO |
| GO:0072574 | hepatocyte proliferation | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IBA |
| GO:0005634 | nucleus | ISO |
| GO:0009986 | cell surface | ISO |
| GO:0016021 | integral component of membrane | IEA |
| GO:0016323 | basolateral plasma membrane | ISO |
| GO:0031410 | cytoplasmic vesicle | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| GO:0005886 | plasma membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-177929 | Signaling by EGFR | IEA |
| R-MMU-179812 | GRB2 events in EGFR signaling | IEA |
| R-MMU-180292 | GAB1 signalosome | IEA |
| R-MMU-180336 | SHC1 events in EGFR signaling | IEA |
| R-MMU-182971 | EGFR downregulation | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-199977 | ER to Golgi Anterograde Transport | IEA |
| R-MMU-199991 | Membrane Trafficking | IEA |
| R-MMU-204005 | COPII-mediated vesicle transport | IEA |
| R-MMU-212718 | EGFR interacts with phospholipase C-gamma | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-446203 | Asparagine N-linked glycosylation | IEA |
| R-MMU-5653656 | Vesicle-mediated transport | IEA |
| R-MMU-5673001 | RAF/MAP kinase cascade | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-5694530 | Cargo concentration in the ER | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-8856825 | Cargo recognition for clathrin-mediated endocytosis | IEA |
| R-MMU-8856828 | Clathrin-mediated endocytosis | IEA |
| R-MMU-8939211 | ESR-mediated signaling | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9009391 | Extra-nuclear estrogen signaling | IEA |
| R-MMU-948021 | Transport to the Golgi and subsequent modification | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0245 | EGF-like domain |
| KW-0325 | Glycoprotein |
| KW-0339 | Growth factor |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0497 | Mitogen |
| KW-0564 | Palmitate |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |