Gene: Abcb1a

Basic information

Tag Content
Uniprot ID P21447; Q5I1Y5;
Entrez ID 18671
Genbank protein ID AAA03243.1; AAA39514.1; AAA39517.1; EDL14677.1; AAA39518.1; AAW56448.1;
Genbank nucleotide ID XM_006503556.3; NM_011076.2; XM_006503555.3;
Ensembl protein ID ENSMUSP00000041204
Ensembl nucleotide ID ENSMUSG00000040584
Gene name ATP-dependent translocase ABCB1
Gene symbol Abcb1a
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (By similarity).
Sequence
MELEEDLKGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRLYM LVGTLAAIIH 60
GVALPLMMLI FGDMTDSFAS VGNVSKNSTN MSEADKRAMF AKLEEEMTTY AYYYTGIGAG 120
VLIVAYIQVS FWCLAAGRQI HKIRQKFFHA IMNQEIGWFD VHDVGELNTR LTDDVSKINE 180
GIGDKIGMFF QAMATFFGGF IIGFTRGWKL TLVILAISPV LGLSAGIWAK ILSSFTDKEL 240
HAYAKAGAVA EEVLAAIRTV IAFGGQKKEL ERYNNNLEEA KRLGIKKAIT ANISMGAAFL 300
LIYASYALAF WYGTSLVISK EYSIGQVLTV FFSVLIGAFS VGQASPNIEA FANARGAAYE 360
VFKIIDNKPS IDSFSKSGHK PDNIQGNLEF KNIHFSYPSR KEVQILKGLN LKVKSGQTVA 420
LVGNSGCGKS TTVQLMQRLY DPLDGMVSID GQDIRTINVR YLREIIGVVS QEPVLFATTI 480
AENIRYGRED VTMDEIEKAV KEANAYDFIM KLPHQFDTLV GERGAQLSGG QKQRIAIARA 540
LVRNPKILLL DEATSALDTE SEAVVQAALD KAREGRTTIV IAHRLSTVRN ADVIAGFDGG 600
VIVEQGNHDE LMREKGIYFK LVMTQTAGNE IELGNEACKS KDEIDNLDMS SKDSGSSLIR 660
RRSTRKSICG PHDQDRKLST KEALDEDVPP ASFWRILKLN STEWPYFVVG IFCAIINGGL 720
QPAFSVIFSK VVGVFTNGGP PETQRQNSNL FSLLFLILGI ISFITFFLQG FTFGKAGEIL 780
TKRLRYMVFK SMLRQDVSWF DDPKNTTGAL TTRLANDAAQ VKGATGSRLA VIFQNIANLG 840
TGIIISLIYG WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF 900
RTVVSLTREQ KFETMYAQSL QIPYRNAMKK AHVFGITFSF TQAMMYFSYA ACFRFGAYLV 960
TQQLMTFENV LLVFSAIVFG AMAVGQVSSF APDYAKATVS ASHIIRIIEK TPEIDSYSTQ 1020
GLKPNMLEGN VQFSGVVFNY PTRPSIPVLQ GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE 1080
RFYDPMAGSV FLDGKEIKQL NVQWLRAQLG IVSQEPILFD CSIAENIAYG DNSRVVSYEE 1140
IVRAAKEANI HQFIDSLPDK YNTRVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS 1200
ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VIQNGKVKEH GTHQQLLAQK 1260
GIYFSMVSVQ AGAKRS 1276

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database


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Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologABCB1403879Q4PLA8Canis lupus familiarisPredictionMore>>
1:1 orthologABCB15243P08183Homo sapiensPublicationMore>>
1:1 orthologAbcb1a18671P21447Mus musculusPredictionMore>>
1:1 orthologABCB1A0A2I3RUL7Pan troglodytesPredictionMore>>
1:1 orthologABCB1100008914G1T8H8Oryctolagus cuniculusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005524 ATP bindingISO
GO:0008559 ATPase-coupled xenobiotic transmembrane transporter activityEXP
GO:0015562 efflux transmembrane transporter activityISO
GO:0015562 efflux transmembrane transporter activityIMP
GO:0016887 ATPase activityISO
GO:0031625 ubiquitin protein ligase bindingISO
GO:0042623 ATPase activity, coupledIDA
GO:0042626 ATPase-coupled transmembrane transporter activityIBA
GO:0042910 xenobiotic transmembrane transporter activityISO
GO:0042910 xenobiotic transmembrane transporter activityIMP
GO:0090554 phosphatidylcholine floppase activityISO
GO:0090554 phosphatidylcholine floppase activityIBA
GO:0090554 phosphatidylcholine floppase activityIDA
GO:0090555 phosphatidylethanolamine flippase activityISO
GO:0090555 phosphatidylethanolamine flippase activityIBA
GO:0090555 phosphatidylethanolamine flippase activityIDA
GO:0099038 ceramide floppase activityISO
GO:0099038 ceramide floppase activityIBA
GO:0099038 ceramide floppase activityIDA
GO:0140328 floppase activityISS
GO:0140328 floppase activityISO
GO:0140328 floppase activityIMP

GO:Biological Process

GO ID GO Term Evidence
GO:0000086 G2/M transition of mitotic cell cycleISO
GO:0009914 hormone transportISO
GO:0033231 carbohydrate exportISO
GO:0035633 maintenance of permeability of blood-brain barrierISO
GO:0043215 daunorubicin transportISO
GO:0045332 phospholipid translocationISO
GO:0045332 phospholipid translocationIBA
GO:0045332 phospholipid translocationIDA
GO:0047484 regulation of response to osmotic stressISO
GO:0050892 intestinal absorptionISO
GO:0055085 transmembrane transportISO
GO:0060548 negative regulation of cell deathISO
GO:0060856 establishment of blood-brain barrierISO
GO:0070633 transepithelial transportISO
GO:0072089 stem cell proliferationISO
GO:0099040 ceramide translocationISO
GO:0099040 ceramide translocationIBA
GO:0099040 ceramide translocationIDA
GO:0140115 export across plasma membraneISO
GO:0140115 export across plasma membraneIMP
GO:1901529 positive regulation of anion channel activityISO
GO:1902396 protein localization to bicellular tight junctionISO
GO:1904446 positive regulation of establishment of Sertoli cell barrierISO
GO:1904478 regulation of intestinal absorptionISO
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membraneISO
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membraneIDA
GO:1990962 xenobiotic transport across blood-brain barrierISO
GO:1990962 xenobiotic transport across blood-brain barrierIMP
GO:1990963 establishment of blood-retinal barrierISO
GO:2001025 positive regulation of response to drugISO
GO:2001225 regulation of chloride transportISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005886 plasma membraneIBA
GO:0005886 plasma membraneTAS
GO:0009986 cell surfaceISO
GO:0016020 membraneISO
GO:0016021 integral component of membraneIEA
GO:0016324 apical plasma membraneISO
GO:0016324 apical plasma membraneIDA
GO:0031526 brush border membraneISO
GO:0045177 apical part of cellISO
GO:0046581 intercellular canaliculusIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-382551 Transport of small moleculesIEA
R-MMU-382556 ABC-family proteins mediated transportIEA

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0067 ATP-binding
KW-1003 Cell membrane
KW-0903 Direct protein sequencing
KW-0325 Glycoprotein
KW-0472 Membrane
KW-0547 Nucleotide-binding
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-1278 Translocase
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030258 MDR1
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter

PROSITE

PROSITE ID PROSITE Term
PS50929 ABC_TM1F
PS00211 ABC_TRANSPORTER_1
PS50893 ABC_TRANSPORTER_2

Pfam

Pfam ID Pfam Term
PF00664 ABC_membrane
PF00005 ABC_tran

Protein-miRNA interaction