| Tag | Content |
|---|---|
| Uniprot ID | Q4PLA8; F1PH01; |
| Entrez ID | 403879 |
| Genbank protein ID | AAY67840.1 |
| Genbank nucleotide ID | NM_001003215.2; XM_014118874.1; XM_014118873.1; |
| Ensembl protein ID | ENSCAFP00000002684 |
| Ensembl nucleotide ID | ENSCAFG00000001835 |
| Gene name | ATP binding cassette subfamily B member 1 |
| Gene symbol | ABCB1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDPEGGRKGS AEKNFWKMGK KSKKNEKKEK KPTVSTFAMF RYSNWLDRLY MLVGTMAAII 60 HGAALPLMML VFGNMTDSFA NAGISRNKTF PVIINESITN NTQHFINHLE EEMTTYAYYY 120 SGIGAGVLVA AYIQVSFWCL AAGRQILKIR KQFFHAIMRQ EIGWFDVHDV GELNTRLTDD 180 VSKINEGIGD KIGMFFQSIA TFFTGFIVGF TRGWKLTLVI LAISPVLGLS AAIWAKILSS 240 FTDKELLAYA KAGAVAEEVL AAIRTVIAFG GQKKELERYN KNLEEAKRIG IKKAITANIS 300 IGAAFLLIYA SYALAFWYGT SLVLSSEYSI GQVLTVFFSV LIGAFSIGQA SPSIEAFANA 360 RGAAYEIFKI IDNKPSIDSY SKSGHKPDNI KGNLEFKNVH FSYPSRKEVK ILKGLNLKVQ 420 SGQTVALVGN SGCGKSTTVQ LMQRLYDPTD GMVCIDGQDI RTINVRHLRE ITGVVSQEPV 480 LFATTIAENI RYGRENVTMD EIEKAVKEAN AYDFIMKLPN KFDTLVGERG AQLSGGQKQR 540 IAIARALVRN PKILLLDEAT SALDTESEAV VQVALDKARK GRTTIVIAHR LSTVRNADVI 600 AGFDDGVIVE KGNHDELMKE KGIYFKLVTM QTRGNEIELE NATGESKSES DALEMSPKDS 660 GSSLIKRRST RRSIHAPQGQ DRKLGTKEDL NENVPPVSFW RILKLNSTEW PYFVVGIFCA 720 IINGGLQPAF SIIFSRIIGI FTRDEDPETK RQNSNMFSVL FLVLGIISFI TFFLQGFTFG 780 KAGEILTKRL RYMVFRSMLR QDVSWFDDPK NTTGALTTRL ANDAAQVKGA IGSRLAVITQ 840 NIANLGTGII ISLIYGWQLT LLLLAIVPII AIAGVVEMKM LSGQALKDKK ELEGAGKIAT 900 EAIENFRTVV SLTREQKFEY MYAQSLQVPY RNSLRKAHIF GVSFSITQAM MYFSYAGCFR 960 FGAYLVANEF MNFQDVLLVF SAIVFGAMAV GQVSSFAPDY AKAKVSAAHV IMIIEKSPLI 1020 DSYSPHGLKP NTLEGNVTFN EVVFNYPTRP DIPVLQGLSL EVKKGQTLAL VGSSGCGKST 1080 VVQLLERFYD PLAGSVLIDG KEIKHLNVQW LRAHLGIVSQ EPILFDCSIA ENIAYGDNSR 1140 VVSHEEIMQA AKEANIHHFI ETLPEKYNTR VGDKGTQLSG GQKQRIAIAR ALVRQPHILL 1200 LDEATSALDT ESEKVVQEAL DKAREGRTCI VIAHRLSTIQ NADLIVVFQN GKVKEHGTHQ 1260 QLLAQKGIYF SMVSVQAGAK R 1281 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ABCB1 | 403879 | Q4PLA8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ABCB1 | 5243 | P08183 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Abcb1a | 18671 | P21447 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | ABCB1 | A0A2I3RUL7 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ABCB1 | 100008914 | G1T8H8 | Oryctolagus cuniculus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016324 | apical plasma membrane |
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0016887 | ATPase activity |
| GO:0042626 | ATPase-coupled transmembrane transporter activity |
| GO:0099038 | ceramide floppase activity |
| GO:0015562 | efflux transmembrane transporter activity |
| GO:0090554 | phosphatidylcholine floppase activity |
| GO:0090555 | phosphatidylethanolamine flippase activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0042910 | xenobiotic transmembrane transporter activity |
| GO:0099040 | ceramide translocation |
| GO:0140115 | export across plasma membrane |
| GO:0000086 | G2/M transition of mitotic cell cycle |
| GO:0045332 | phospholipid translocation |
| GO:1901529 | positive regulation of anion channel activity |
| GO:2001225 | regulation of chloride transport |
| GO:0047484 | regulation of response to osmotic stress |
| GO:0072089 | stem cell proliferation |
| GO:0070633 | transepithelial transport |