| Tag | Content |
|---|---|
| Uniprot ID | Q00939 |
| Entrez ID | 24370 |
| Genbank protein ID | AAA40812.1 |
| Genbank nucleotide ID | NM_012560.2 |
| Ensembl protein ID | ENSRNOP00000067118 |
| Ensembl nucleotide ID | ENSRNOG00000047891 |
| Gene name | Forkhead box protein G1 |
| Gene symbol | Foxg1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. |
| Sequence | MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP 60 APQPPPPPPQ QQQQPPPAPQ PPQARGAPAA DDDKGPQPLL LPPSAALDGA KADALGAKGE 120 PGGGPAELAP VGPDEKEKGA GAGGEEKKGA GEGGKDGEGG KEGDKKNGKY EKPPFSYNAL 180 IMMAIRQSPE KRLTLNGIYE FIMKNFPYYR ENKQGWQNSI RHNLSLNKCF VKVPRHYDDP 240 GKGNYWMLDP SSDDVFIGGT TGKLRRRSTT SRAKLAFKRG ARLTSTGLTF MDRAGSLYWP 300 MSPFLSLHHP RASSTLSYNG TTSAYPSHPM PYSSVLTQNS LGNNHSFSTA NGLSVDRLVN 360 GEIPYATHHL TAAALAASVP CGLSVPCSGT YSLNPCSVNL LAGQTSYFFP HVPHPSMTSQ 420 TSTSMSARAA SSSTSPQAPS TLPCESLRPS LPSFTTGLSG GLSDYFTHQN QGSSSNPLIH 480 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOXG1 | A0A452FP40 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FOXG1 | 2290 | P55316 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Foxg1 | 15228 | Q60987 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | FOXG1 | 467416 | H2R9E1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOXG1 | A0A287A2J5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Foxg1 | 24370 | Q00939 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | foxg1a | 30274 | Q568V0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0043565 | sequence-specific DNA binding |
| GO:0007568 | aging |
| GO:0016199 | axon midline choice point recognition |
| GO:0007420 | brain development |
| GO:0048667 | cell morphogenesis involved in neuron differentiation |
| GO:0021954 | central nervous system neuron development |
| GO:0021987 | cerebral cortex development |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0030900 | forebrain development |
| GO:0042472 | inner ear morphogenesis |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0022008 | neurogenesis |
| GO:0048664 | neuron fate determination |
| GO:0045787 | positive regulation of cell cycle |
| GO:0002052 | positive regulation of neuroblast proliferation |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0021852 | pyramidal neuron migration |
| GO:0051726 | regulation of cell cycle |
| GO:0010468 | regulation of gene expression |
| GO:0007346 | regulation of mitotic cell cycle |
| GO:2000177 | regulation of neural precursor cell proliferation |
| Pfam ID | Pfam Term |
|---|---|
| PF00250 | Forkhead |