Gene: Foxg1

Basic information

Tag Content
Uniprot ID Q60987; Q80VP3;
Entrez ID 15228
Genbank protein ID AAH46958.2; AAB42158.1;
Genbank nucleotide ID NM_008241.2; NM_001160112.1;
Ensembl protein ID ENSMUSP00000021333; ENSMUSP00000136372;
Ensembl nucleotide ID ENSMUSG00000020950
Gene name Forkhead box protein G1
Gene symbol Foxg1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
Sequence
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP 60
APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL LLPPSTALDG AKADALGAKG 120
EPGGGPAELA PVGPDEKEKG AGAGGEEKKG AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA 180
LIMMAIRQSP EKRLTLNGIY EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD 240
PGKGNYWMLD PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW 300
PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST ANGLSVDRLV 360
NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN LLAGQTSYFF PHVPHPSMTS 420
QTSTSMSARA ASSSTSPQAP STLPCESLRP SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI 480
H 481

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFOXG1A0A452FP40Capra hircusPredictionMore>>
1:1 orthologFOXG12290P55316Homo sapiensPublicationMore>>
1:1 orthologFoxg115228Q60987Mus musculusPredictionMore>>
1:1 orthologFOXG1467416H2R9E1Pan troglodytesPredictionMore>>
1:1 orthologFOXG1A0A287A2J5Sus scrofaPredictionMore>>
1:1 orthologFoxg124370Q00939Rattus norvegicusPredictionMore>>
1:1 orthologfoxg1a30274Q568V0Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specificIC
GO:0005515 protein bindingIPI
GO:0043565 sequence-specific DNA bindingIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIIDA
GO:0002052 positive regulation of neuroblast proliferationIMP
GO:0007346 regulation of mitotic cell cycleIMP
GO:0007568 agingIEA
GO:0009953 dorsal/ventral pattern formationIMP
GO:0010468 regulation of gene expressionIMP
GO:0016199 axon midline choice point recognitionIMP
GO:0021852 pyramidal neuron migrationIDA
GO:0021954 central nervous system neuron developmentIMP
GO:0021987 cerebral cortex developmentIDA
GO:0022008 neurogenesisIDA
GO:0030900 forebrain developmentIMP
GO:0042472 inner ear morphogenesisIGI
GO:0042472 inner ear morphogenesisIMP
GO:0045665 negative regulation of neuron differentiationIMP
GO:0045666 positive regulation of neuron differentiationIGI
GO:0045787 positive regulation of cell cycleIMP
GO:0045892 negative regulation of transcription, DNA-templatedISO
GO:0048664 neuron fate determinationIDA
GO:0048667 cell morphogenesis involved in neuron differentiationIMP
GO:0051726 regulation of cell cycleIDA
GO:2000177 regulation of neural precursor cell proliferationIGI

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIDA
GO:0005654 nucleoplasmTAS

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-212436 Generic Transcription PathwayIEA
R-MMU-73857 RNA Polymerase II TranscriptionIEA
R-MMU-74160 Gene expression (Transcription)IEA
R-MMU-9614085 FOXO-mediated transcriptionIEA
R-MMU-9617828 FOXO-mediated transcription of cell cycle genesIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

PROSITE

PROSITE ID PROSITE Term
PS00657 FORK_HEAD_1
PS00658 FORK_HEAD_2
PS50039 FORK_HEAD_3

Pfam

Pfam ID Pfam Term
PF00250 Forkhead

Protein-protein interaction

Protein-miRNA interaction