| Tag | Content |
|---|---|
| Uniprot ID | Q5U367; Q811A5; |
| Entrez ID | 288583 |
| Genbank protein ID | CAD23628.1; AAH85683.1; |
| Genbank nucleotide ID | NM_178101.3 |
| Ensembl protein ID | ENSRNOP00000001921 |
| Ensembl nucleotide ID | ENSRNOG00000001417 |
| Gene name | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 |
| Gene symbol | Plod3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens. Essential for normal formation of basement membranes (By similarity). |
| Sequence | MAASVPEPRL LLLLLLLLPP LPPVTSASDR PRGANPVNPD KLLVITVATA ETEGYRRFLQ 60 SAEFFNYTVR TLGLGQEWRG GDVARTVGGG QKVRWLKKEM EKYASQEDMI IMFVDSYDVI 120 LASSPTELLK KFVQSGSHLL FSAESFCWPD WGLAEQYPEV GVGKRFLNSG GFIGFAPTIH 180 RIVRQWKYKD DDDDQLFYTQ LYLDPGLREK LKLSLDHKSR IFQNLNGALD EVVLKFDQNR 240 VRIRNVAYDT LPVVVHGNGP TKLQLNYLGN YVPNGWTPQG GCGFCNLNRR TLPGGQPPPR 300 VLLAVFVEQP TPFLPRFLQR LLLLDYPPDR ISLFLHNNEV YHEPHIADAW PQLQDHFSAV 360 KLVGPEEALS SGEARDMAMD SCRQNPECEF YFSLDADAVL TNPETLRILI EQNRKVIAPM 420 LSRHGKLWSN FWGALSPDEY YARSEDYVEL VQRKRVGLWN VPYISQAYVI RGETLRTELP 480 EKEVFSSSDT DPDMAFCRSV RDKGIFLHLS NQHEFGRLLS TSHYDTDHLH PDLWQIFDNP 540 VDWREQYIHE NYSRALDGEG LVEQPCPDVY WFPLLTEQMC DELVEEMEHY GQWSGGRHED 600 SRLAGGYENV PTVDIHMKQV GYEDQWLQLL RTYVGPMTEH LFPGYHTKTR AVMNFVVRYR 660 PDEQPSLRPH HDSSTFTLNV ALNHKGVDYE GGGCRFLRYD CRVSSPRKGW ALLHPGRLTH 720 YHEGLPTTRG TRYIMVSFVD P 741 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PLOD3 | 514996 | F1MET0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PLOD3 | 479730 | E2RTL4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PLOD3 | 100861039 | A0A452EQP3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PLOD3 | 8985 | O60568 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Plod3 | 26433 | Q9R0E1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PLOD3 | I3LA84 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Plod3 | 288583 | Q5U367 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | plod3 | 556077 | A3KNH4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005783 | endoplasmic reticulum |
| GO:0005788 | endoplasmic reticulum lumen |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0005615 | extracellular space |
| GO:0005794 | Golgi apparatus |
| GO:0005791 | rough endoplasmic reticulum |
| GO:0005802 | trans-Golgi network |
| GO:0005506 | iron ion binding |
| GO:0031418 | L-ascorbic acid binding |
| GO:0050211 | procollagen galactosyltransferase activity |
| GO:0033823 | procollagen glucosyltransferase activity |
| GO:0008475 | procollagen-lysine 5-dioxygenase activity |
| GO:0070831 | basement membrane assembly |
| GO:0032870 | cellular response to hormone stimulus |
| GO:0030199 | collagen fibril organization |
| GO:0032963 | collagen metabolic process |
| GO:0001886 | endothelial cell morphogenesis |
| GO:0048730 | epidermis morphogenesis |
| GO:0046947 | hydroxylysine biosynthetic process |
| GO:0001701 | in utero embryonic development |
| GO:0060425 | lung morphogenesis |
| GO:0021915 | neural tube development |
| GO:0017185 | peptidyl-lysine hydroxylation |
| GO:0008104 | protein localization |
| GO:0006493 | protein O-linked glycosylation |
| GO:0042311 | vasodilation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0223 | Dioxygenase |
| KW-1015 | Disulfide bond |
| KW-0256 | Endoplasmic reticulum |
| KW-0325 | Glycoprotein |
| KW-0328 | Glycosyltransferase |
| KW-0408 | Iron |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0511 | Multifunctional enzyme |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0847 | Vitamin C |