Gene: Nuak2

Basic information

Tag Content
Uniprot ID Q66HE5
Entrez ID 289419
Genbank protein ID AAH81899.1
Genbank nucleotide ID NM_001007617.1
Ensembl protein ID ENSRNOP00000000039
Ensembl nucleotide ID ENSRNOG00000000034
Gene name NUAK family SNF1-like kinase 2
Gene symbol Nuak2
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).
Sequence
MESVALHRRG NLAPSASALA TESARPLADR LIKSPKPLMK KQAVKRHHHK HNLRHRYEFL 60
ETLGKGTYGK VKKARESSGR LVAIKSIRKD KIKDEQDLLH IRREIEIMSS LNHPHIIAIH 120
EVFENSSKIV IVMEYASRGD LYDYISERPR LNERDARHFF RQIVSALHYC HQNGIVHRDL 180
KLENILLDAS GNIKIADFGL SNLYHKGKFL QTFCGSPLYA SPEIVNGKPY VGPEVDSWSL 240
GVLLYILVHG TMPFDGQDHK TLVKQISSGA YREPCKPSDA CGLIRWLLMV NPIRRATLED 300
VASHWWVNWG YSTRIGEQEA LREGGHPSGD SGRASMADWL RRSSRPLLEN GAKVCSFFKQ 360
HVPGGGSTGP GLERQHSLKK SRKENDMAQT LQNDPAEDTS SRPGKNSLKL PKGILKKKAS 420
PSSGEVQEGP QELRPVSNTP GQPVPAIPLL PRKGILKKSR QRESGYYSSP EPSESGELLD 480
AGDVFVSGDP MEQKSPQASG RLHRKGILKL NGKFSRTALE GTAPSTFGSL DQLASPHPTA 540
RASRPSGAVS EDSILSSESF DQLDLPERLP ETPLRGCVSV DNLRRLEQPP SEGLKRWWQE 600
SLGDSCFSLT DCQEVTAAYR QALGICSKLS

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Gene ontology

Functional annotations

Keywords

Interpro

PROSITE

Pfam