| Tag | Content |
|---|---|
| Uniprot ID | Q66HE5 |
| Entrez ID | 289419 |
| Genbank protein ID | AAH81899.1 |
| Genbank nucleotide ID | NM_001007617.1 |
| Ensembl protein ID | ENSRNOP00000000039 |
| Ensembl nucleotide ID | ENSRNOG00000000034 |
| Gene name | NUAK family SNF1-like kinase 2 |
| Gene symbol | Nuak2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity). |
| Sequence | MESVALHRRG NLAPSASALA TESARPLADR LIKSPKPLMK KQAVKRHHHK HNLRHRYEFL 60 ETLGKGTYGK VKKARESSGR LVAIKSIRKD KIKDEQDLLH IRREIEIMSS LNHPHIIAIH 120 EVFENSSKIV IVMEYASRGD LYDYISERPR LNERDARHFF RQIVSALHYC HQNGIVHRDL 180 KLENILLDAS GNIKIADFGL SNLYHKGKFL QTFCGSPLYA SPEIVNGKPY VGPEVDSWSL 240 GVLLYILVHG TMPFDGQDHK TLVKQISSGA YREPCKPSDA CGLIRWLLMV NPIRRATLED 300 VASHWWVNWG YSTRIGEQEA LREGGHPSGD SGRASMADWL RRSSRPLLEN GAKVCSFFKQ 360 HVPGGGSTGP GLERQHSLKK SRKENDMAQT LQNDPAEDTS SRPGKNSLKL PKGILKKKAS 420 PSSGEVQEGP QELRPVSNTP GQPVPAIPLL PRKGILKKSR QRESGYYSSP EPSESGELLD 480 AGDVFVSGDP MEQKSPQASG RLHRKGILKL NGKFSRTALE GTAPSTFGSL DQLASPHPTA 540 RASRPSGAVS EDSILSSESF DQLDLPERLP ETPLRGCVSV DNLRRLEQPP SEGLKRWWQE 600 SLGDSCFSLT DCQEVTAAYR QALGICSKLS |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NUAK2 | A0A452EIF1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NUAK2 | 81788 | Q9H093 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nuak2 | 74137 | Q8BZN4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NUAK2 | 457667 | H2Q0Z2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NUAK2 | A0A287B415 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nuak2 | 289419 | Q66HE5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0016607 | nuclear speck |
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0000287 | magnesium ion binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0030036 | actin cytoskeleton organization |
| GO:0006915 | apoptotic process |
| GO:0042149 | cellular response to glucose starvation |
| GO:0035556 | intracellular signal transduction |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0006468 | protein phosphorylation |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |