| Tag | Content |
|---|---|
| Uniprot ID | Q8BZN4; Q80ZW3; Q8CIC0; Q9DBV0; |
| Entrez ID | 74137 |
| Genbank protein ID | BAC28421.1; AAH33302.1; AAH46833.1; BAC28575.1; BAB23518.1; |
| Genbank nucleotide ID | NM_028778.4; NM_001195025.1; |
| Ensembl protein ID | ENSMUSP00000080769; ENSMUSP00000072039; |
| Ensembl nucleotide ID | ENSMUSG00000009772 |
| Gene name | NUAK family SNF1-like kinase 2 |
| Gene symbol | Nuak2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 22689267 |
| Functional description | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity). |
| Sequence | MESVALLQRP SQAPSASALA SESARPLADG LIKSPKPLMK KQAVKRHHHK HNLRHRYEFL 60 ETLGKGTYGK VKKARESSGR LVAIKSIRKD KIKDEQDLLH IRREIEIMSS LNHPHIIAIH 120 EVGRSRLVTV FENSSKIVIV MEYASRGDLY DYISERPRLS ERDARHFFRQ IVSALHYCHQ 180 NGIVHRDLKL ENILLDANGN IKIADFGLSN LYHKGKFLQT FCGSPLYASP EIVNGKPYVG 240 PEVDSWSLGV LLYILVHGTM PFDGQDHKTL VKQISNGAYR EPPKPSDACG LIRWLLMVNP 300 TRRATLEDVA SHWWVNWGYT TGVGEQEALR EGGHPSGDFG RASMADWLRR SSRPLLENGA 360 KVCSFFKQHV PGGGSTVPGL ERQHSLKKSR KENDMAQNLQ GDPAEDTSSR PGKSSLKLPK 420 GILKKKSSTS SGEVQEDPQE LRPVPDTPGQ PVPAVSLLPR KGILKKSRQR ESGYYSSPEP 480 SESGELLDAS DVFVSGDPVE QKSPQASGLL LHRKGILKLN GKFSRTALEG TTPSTFGSLD 540 QLASSHPAAR PSRPSGAVSE DSILSSESFD QLDLPERLPE TPLRGCVSVD NLRGLEQPPS 600 EGLKRWWQES LGDSCFSLTD CQEVTAAYRQ ALGICSKLS 639 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NUAK2 | A0A452EIF1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NUAK2 | 81788 | Q9H093 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nuak2 | 74137 | Q8BZN4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NUAK2 | 457667 | H2Q0Z2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NUAK2 | A0A287B415 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nuak2 | 289419 | Q66HE5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000287 | magnesium ion binding | ISS |
| GO:0000287 | magnesium ion binding | ISO |
| GO:0004674 | protein serine/threonine kinase activity | ISS |
| GO:0004674 | protein serine/threonine kinase activity | ISO |
| GO:0004674 | protein serine/threonine kinase activity | IBA |
| GO:0005524 | ATP binding | ISS |
| GO:0005524 | ATP binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006468 | protein phosphorylation | ISS |
| GO:0006468 | protein phosphorylation | ISO |
| GO:0006468 | protein phosphorylation | IBA |
| GO:0006915 | apoptotic process | IEA |
| GO:0030036 | actin cytoskeleton organization | ISS |
| GO:0030036 | actin cytoskeleton organization | ISO |
| GO:0035556 | intracellular signal transduction | IBA |
| GO:0042149 | cellular response to glucose starvation | ISS |
| GO:0042149 | cellular response to glucose starvation | ISO |
| GO:0043066 | negative regulation of apoptotic process | ISS |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IBA |
| GO:0005737 | cytoplasm | IBA |
| GO:0016607 | nuclear speck | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |