| Tag | Content |
|---|---|
| Uniprot ID | Q6PFE3; A2AIV0; |
| Entrez ID | 623474 |
| Genbank protein ID | AAH57604.1 |
| Genbank nucleotide ID | NM_001039556.3 |
| Ensembl protein ID | ENSMUSP00000066977 |
| Ensembl nucleotide ID | ENSMUSG00000078773 |
| Gene name | DNA repair and recombination protein RAD54B |
| Gene symbol | Rad54b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. |
| Sequence | MRRSAAPSQV QGKSFKKTRF IPPGRSNADV SKEITKMSPD PKLFQGAEQS QNDPGVCSSN 60 PCPSEGIPRE VGDGTRVDPL PPVHSASKEI TESKAQEEEA SSLLKYFSVV WCKASKKKHK 120 KWEGDAILIV RGRSFTLKDL EGKDIGRGIG YKFKDLENVE EGQTLIIGGK EIEILGTISS 180 DDFNSGKCFQ HGSGSPAVPS SQAARKCFSN PFKSVCQSTQ AQGKRWNDCR PRHNPCTPNA 240 LVMPRPDENH QRMFNRHCSP IVDVVIDPHL VHHLRPHQKD GIIFLYECVM GMRAVGKCGA 300 ILADEMGLGK TLQCISLIWT LQCQGPYGGK PVIKKTLIVT PGSLVNNWRK EFQKWLGSER 360 IKIFTVDQDH KVEEFINSTF HSVLIISYEM LLRSLDQIKT IPFGLLICDE GHRLKNSSIK 420 TTTALSSLSC EKTVILTGTP VQNDLQEFFA LVDFVNPGIL GSLSSYRKIY EEPIIISREP 480 SSSKEERELG ERRATELTRL TGRFILRRTQ EVINKYLPPK IENVVFCRPG ALQIELYRKL 540 LRSQSVRFCL QGLLENSAHL ICIGALKKLC NHPCLLFSSV KGKEFSSSCE ENEERNLCQG 600 LLSVFPAGYN PLQFSEEESG KLQVLVKLLA VIHELRPTEK VILVSNYRQT LNVLEEVCKR 660 HGYACARLDG QTPVSQRQHI VDSFNSKYST DFIFLLSSKA GGVGLNLIGG SHLILYDIDW 720 NPATDIQAMS RVWRDGQKHP VHIYRLLTTG TIEEKIYQRQ ISKQGLSGAV VDLTRSSEHI 780 QFSVEELKNL FTLHESSHCV THDLLDCECT GEKGHTEDAS EGPVASRQCQ FGPQKSDALR 840 PLSMSQLKQW KHFSGDHLNL PDPFLERIRE NVSFFFQNIT NQAPAV 886 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD54B | 533414 | F1MSA4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD54B | 487053 | F1PW14 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | FSBP | 102186978 | A0A452DW56 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD54B | 25788 | Q9Y620 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rad54b | 623474 | Q6PFE3 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | Rad54b | 313063 | F1LYB7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad54b | 560482 | E9QHY4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IEA |
| GO:0004386 | helicase activity | IEA |
| GO:0005524 | ATP binding | IEA |
| GO:0015616 | DNA translocase activity | ISO |
| GO:0015616 | DNA translocase activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000724 | double-strand break repair via homologous recombination | IGI |
| GO:0000724 | double-strand break repair via homologous recombination | ISO |
| GO:0000724 | double-strand break repair via homologous recombination | IMP |
| GO:0000724 | double-strand break repair via homologous recombination | IBA |
| GO:0006974 | cellular response to DNA damage stimulus | IMP |
| GO:0006974 | cellular response to DNA damage stimulus | IGI |
| GO:0007131 | reciprocal meiotic recombination | IBA |
| GO:0008340 | determination of adult lifespan | IGI |
| GO:0010212 | response to ionizing radiation | IMP |
| GO:0010212 | response to ionizing radiation | IGI |
| GO:0042493 | response to drug | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|