CleftGeneDB-Search

Gene: Kif20b

Basic information

Tag	Content
Uniprot ID	Q80WE4; E9QPW5; Q3V347; Q80VC0; Q8BLI2; Q99PT5;
Entrez ID	240641
Genbank protein ID	BAE43340.1; BAB32494.1; AAP14646.1; AAH48954.1; BAC32207.1;
Genbank nucleotide ID	NM_183046.1; XM_006527086.2; XM_006527081.2; XM_006527080.2;
Ensembl protein ID	ENSMUSP00000153034; ENSMUSP00000084599;
Ensembl nucleotide ID	ENSMUSG00000024795
Gene name	Kinesin-like protein KIF20B
Gene symbol	Kif20b
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO
Developmental stage
Data sources	Manually collected
Reference	22821687; 29208648;
Functional description	Plus-end-directed motor enzyme that is required for completion of cytokinesis (By similarity). Required for proper midbody organization and abscission in polarized cortical stem cells (PubMed:24173802). Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner (PubMed:23864681). In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681). Involved in cerebral cortex growth (PubMed:24173802). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (By similarity).
Sequence	MESHLNPDGV PRPSYVFSAD PIARPLEINF DGVKLDLSHE FSLVASNPAA NSLGSKNYLQ 60 VCLRIRPFTQ SEKEHEAEGC VQVLDSQSVL LKDPQSILGH LSEKSSGQVA QKFSFSKVFG 120 PETSQKEFFL GCIMQPVKDL LEGHSRLIFT YGLTNSGKTY TFQGTEENIG ILPRTLNVLF 180 DSLQERLYTK MSFKPHRCRE YLKLSSDQEK EESANKNTLL RQIKEVTIHN DSYDVLCGHL 240 TNSLTIPEFE ESVNSCDQSS LNVDNIKYSV WVSFFEIYNE SIYDLFVPVS SKFQKRKMLR 300 LSQDIKGYSF IKDLQWVQVS DSKEAYRLLK LGVKHQSVAF TKLNNASSRS HSIFTIRILQ 360 IEDSEIPRVT RVSELSLCDL AGSERSMKTQ NEGERLREAG NINTSLLTLG KCINVLKNSE 420 KSKVQHVPFR ESKLTHYFQS FFTGKGKICM IINISQSCSA YDETLNVLKF STTAQRVYVP 480 DTLSSSQEKS FASNKSLQDV SLDSNLDNKI LNVKRKTVSW ENSLEDVLEN EDLVEDLEEN 540 EETQNMETEL TDEDSDKSLE ECRVSTCHKK NKELLDLIEK LNKRLINENK EKLTLELKIR 600 EEVTQEFTQY WSQREADFKE TLLHEREILE ENAERRLAIF KDLVGKCDSQ DEPTNRICDI 660 ELETEEAHNY VGVEDIFHSL QDDVTDIKKQ AELAHLYITS LVDPQEAIAC LQLKFNQVKA 720 ELAETKEELI KAQEELKNRE SNSLVQALKT SSKVDTSLTS NKSTCNETSE MPKNSRAQTH 780 SERKRLNEDG LQLGEPPAKK GLILVSPPIT EEQNKMGEMQ QSVSEVVEGN RVLKEKNEEL 840 KRLLTIGENE LRNEKEEKAE LNKQVVSLQQ QLRFFEEKNS SLRADVEQIQ ASYNSAVAEL 900 QTQKAVNQEQ RDRILKLSQE METAARSIES NVSQIKQMQT KIDELRSLDS PSHISKIDLL 960 NLQDLSSGAK GDNCLNTSQQ LPGGDFSSTW VKEYHTQEIS RENSFHASIE AIWEECKEIV 1020 KASSKKSHQI QGLEEQIEKL QVEVKGYREE NSDLRAQESQ GKNRDHQLKE KESLIQQLRE 1080 ELQEKSVSLR VQVQLVAERE QALSELSQDV TCYKAKIKDL EVIVETQKDE CKRLVELEQS 1140 ILEKESAILK LEANLKECEA KHQDHIRTND LSAKEVKFRE EVTRLANNLH DTKQLLQSKE 1200 EENEISRQET EKLKEELAAN SILTQNLKAD LQKKEEDCAE LKEKFIDAKK QIEQVQREVS 1260 VMRDEEKLLR IKINELEKKK NQYSQDLDMK QRTIQQLKEQ LSNQKMEEAV QQYEKVCKDL 1320 SVKEKLVEDM RLTLVEQEQT QAEQDRVLEA KSEEADWLAT ELDKWKEKFK DLETRSNQRL 1380 NTGTMDDLDV LTRKFSKLQD ELQESEEKYK ADRKKWLEEK AVLTTQAKEA ENVRNREMRK 1440 YADDRERCLK LQNEVETLTA QLAEKNSELQ KWREERDQLV TAVETQMKAL LSSCKHKDEE 1500 IQELRKAAAK STGTENQTMN PKPEYNDSVD LGGVETEPQS TSLEISRNTA EDGSVVLDSC 1560 EVSTENVQST RFPKPELEIQ FTPLQPNKMA VKHPGCPTPV TIKIPKARKR KSGEVEEDLV 1620 KCENKKNSTP RSNVKFPVSE HRNSPVKKEQ KVSVGPSSKK TYSLRSQAST VSANIASKKR 1680 EGTLQKFGDF LQHSPTILQS KAKKIIETMS SPKLSTVEVS KENVSQPKKA KRKLYRNEIS 1740 SPINISGQVI LMEQKVKETD HQILKRRLRT RTAK 1774

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	KIF20B		A0A452EC51		Capra hircus	Prediction	More>>
1:1 ortholog	KIF20B	9585	Q96Q89		Homo sapiens	Prediction	More>>
1:1 ortholog	Kif20b	240641	Q80WE4	CPO	Mus musculus	Publication	More>>
1:1 ortholog	KIF20B	450592	H2R321		Pan troglodytes	Prediction	More>>
1:1 ortholog		100155885	A0A480ZX77		Sus scrofa	Prediction	More>>
1:1 ortholog	KIF20B	100339334	G1SHM7		Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Kif20b	309523	D3ZX13		Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs224726071	p.Val10Leu	missense variant	-	NC_000085.6:g.34924653G>T	UniProt
rs50824830	p.Ala49Gly	missense variant	-	NC_000085.6:g.34924771C>G	UniProt
rs37041442	p.His100Gln	missense variant	-	NC_000085.6:g.34929092C>A	UniProt
rs48126182	p.Leu130Arg	missense variant	-	NC_000085.6:g.34929721T>G	UniProt
rs1132869210	p.Glu200Ter	stop gained	-	NC_000085.6:g.34931662G>T	UniProt
rs37989295	p.Val253Met	missense variant	-	NC_000085.6:g.34934952G>A	UniProt
rs224423040	p.Cys458Ser	missense variant	-	NC_000085.6:g.34937417T>A	UniProt
rs216866473	p.Lys509Arg	missense variant	-	NC_000085.6:g.34938350A>G	UniProt
rs36378724	p.Ser555Cys	missense variant	-	NC_000085.6:g.34938487A>T	UniProt
rs255930758	p.Glu561Lys	missense variant	-	NC_000085.6:g.34938505G>A	UniProt
rs38206724	p.Glu740Asp	missense variant	-	NC_000085.6:g.34941437G>C	UniProt
rs243522530	p.Ala777Ser	missense variant	-	NC_000085.6:g.34947653G>T	UniProt
rs248552532	p.Glu812Asp	missense variant	-	NC_000085.6:g.34949775G>T	UniProt
rs13483601	p.Gly817Glu	missense variant	-	NC_000085.6:g.34949789G>A	UniProt
rs220048233	p.Val865Ile	missense variant	-	NC_000085.6:g.34949932G>A	UniProt
rs237492055	p.Arg873Cys	missense variant	-	NC_000085.6:g.34949956C>T	UniProt
rs51318213	p.Asn894Asp	missense variant	-	NC_000085.6:g.34950019A>G	UniProt
rs233264601	p.Arg911Gly	missense variant	-	NC_000085.6:g.34950070A>G	UniProt
rs247347975	p.Arg911Ser	missense variant	-	NC_000085.6:g.34950072G>T	UniProt
rs1134770174	p.Thr923Asn	missense variant	-	NC_000085.6:g.34950107C>A	UniProt
rs259157486	p.Glu929Lys	missense variant	-	NC_000085.6:g.34950124G>A	UniProt
rs226950204	p.Ser930Asn	missense variant	-	NC_000085.6:g.34950128G>A	UniProt
rs245309934	p.Asn931Ser	missense variant	-	NC_000085.6:g.34950131A>G	UniProt
rs213173889	p.Leu962Phe	missense variant	-	NC_000085.6:g.34950223C>T	UniProt
rs254949622	p.Gln1060Glu	missense variant	-	NC_000085.6:g.34950517C>G	UniProt
rs217864972	p.Asn1063Ser	missense variant	-	NC_000085.6:g.34950527A>G	UniProt
rs250935603	p.Glu1180Lys	missense variant	-	NC_000085.6:g.34950877G>A	UniProt
rs219748230	p.Arg1184Gln	missense variant	-	NC_000085.6:g.34950890G>A	UniProt
rs231412563	p.His1190Arg	missense variant	-	NC_000085.6:g.34950908A>G	UniProt
rs220353384	p.Ile1205Met	missense variant	-	NC_000085.6:g.34950954T>G	UniProt
rs251152220	p.Ser1206Asn	missense variant	-	NC_000085.6:g.34950956G>A	UniProt
rs578802285	p.Ser1302Asn	missense variant	-	NC_000085.6:g.34954722G>A	UniProt
rs580066642	p.Arg1346Trp	missense variant	-	NC_000085.6:g.34956031C>T	UniProt
rs212176541	p.Glu1404Asp	missense variant	-	NC_000085.6:g.34959418A>C	UniProt
rs240223021	p.Val1433Leu	missense variant	-	NC_000085.6:g.34959503G>C	UniProt
rs254237417	p.Arg1439Lys	missense variant	-	NC_000085.6:g.34959522G>A	UniProt
rs258695278	p.Met1487Val	missense variant	-	NC_000085.6:g.34966140A>G	UniProt
rs587494949	p.Pro1521Leu	missense variant	-	NC_000085.6:g.34968135C>T	UniProt
rs584140731	p.Gly1553Arg	missense variant	-	NC_000085.6:g.34969923G>A	UniProt
rs1133363650	p.Met1589Lys	missense variant	-	NC_000085.6:g.34970032T>A	UniProt
rs578596576	p.Phe1636Cys	missense variant	-	NC_000085.6:g.34972452T>G	UniProt
rs36783253	p.Val1654Phe	missense variant	-	NC_000085.6:g.34972865G>T	UniProt

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003777	microtubule motor activity	IBA
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0008017	microtubule binding	ISS
GO:0008017	microtubule binding	ISO
GO:0008017	microtubule binding	IBA
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	ISS
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	ISO
GO:0016887	ATPase activity	ISS
GO:0016887	ATPase activity	ISO
GO:0016887	ATPase activity	IBA
GO:0042803	protein homodimerization activity	ISS
GO:0042803	protein homodimerization activity	ISO
GO:0050699	WW domain binding	ISO

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001843	neural tube closure	IMP
GO:0007018	microtubule-based movement	IBA
GO:0007049	cell cycle	IEA
GO:0007088	regulation of mitotic nuclear division	IEA
GO:0008284	positive regulation of cell population proliferation	ISS
GO:0008284	positive regulation of cell population proliferation	ISO
GO:0008284	positive regulation of cell population proliferation	IMP
GO:0032467	positive regulation of cytokinesis	ISS
GO:0032467	positive regulation of cytokinesis	ISO
GO:0035372	protein localization to microtubule	IMP
GO:0048812	neuron projection morphogenesis	IMP
GO:0051301	cell division	IEA
GO:0070201	regulation of establishment of protein localization	IDA
GO:0090316	positive regulation of intracellular protein transport	IMP
GO:1903438	positive regulation of mitotic cytokinetic process	IMP
GO:2000114	regulation of establishment of cell polarity	IGI
GO:2000114	regulation of establishment of cell polarity	IMP
GO:2001222	regulation of neuron migration	IGI
GO:2001224	positive regulation of neuron migration	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	ISS
GO:0005634	nucleus	ISO
GO:0005634	nucleus	IBA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	ISS
GO:0005654	nucleoplasm	ISO
GO:0005730	nucleolus	ISS
GO:0005730	nucleolus	ISO
GO:0005737	cytoplasm	ISO
GO:0005813	centrosome	ISS
GO:0005813	centrosome	ISO
GO:0005829	cytosol	ISO
GO:0005871	kinesin complex	IBA
GO:0005874	microtubule	IBA
GO:0015630	microtubule cytoskeleton	IDA
GO:0030426	growth cone	IEA
GO:0030496	midbody	ISO
GO:0030496	midbody	IDA
GO:0045171	intercellular bridge	ISO
GO:0048471	perinuclear region of cytoplasm	IDA
GO:0051233	spindle midzone	IDA
GO:0070938	contractile ring	ISS
GO:0070938	contractile ring	ISO
GO:0097431	mitotic spindle pole	ISS
GO:0097431	mitotic spindle pole	ISO
GO:1990023	mitotic spindle midzone	ISS
GO:1990023	mitotic spindle midzone	ISO

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-109582	Hemostasis	IEA
R-MMU-1280218	Adaptive Immune System	IEA
R-MMU-168256	Immune System	IEA
R-MMU-199991	Membrane Trafficking	IEA
R-MMU-2132295	MHC class II antigen presentation	IEA
R-MMU-5653656	Vesicle-mediated transport	IEA
R-MMU-6811434	COPI-dependent Golgi-to-ER retrograde traffic	IEA
R-MMU-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	IEA
R-MMU-8856688	Golgi-to-ER retrograde transport	IEA
R-MMU-983189	Kinesins	IEA
R-MMU-983231	Factors involved in megakaryocyte development and platelet production	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0067	ATP-binding
KW-0131	Cell cycle
KW-0132	Cell division
KW-0966	Cell projection
KW-0175	Coiled coil
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-0493	Microtubule
KW-0498	Mitosis
KW-0505	Motor protein
KW-0547	Nucleotide-binding
KW-0539	Nucleus
KW-0553	Oncogene
KW-0597	Phosphoprotein
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR028828	KIF20B
IPR027640	Kinesin-like_fam
IPR019821	Kinesin_motor_CS
IPR001752	Kinesin_motor_dom
IPR036961	Kinesin_motor_dom_sf
IPR027417	P-loop_NTPase

PROSITE

PROSITE ID	PROSITE Term
PS00411	KINESIN_MOTOR_1
PS50067	KINESIN_MOTOR_2

Pfam

Pfam ID	Pfam Term
PF00225	Kinesin

Gene: Kif20b

Basic information

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction