Gene: Rdh10

Basic information

Tag Content
Uniprot ID Q80ZF7
Entrez ID 353252
Genbank protein ID AAO31688.1
Genbank nucleotide ID NM_181478.2
Ensembl protein ID ENSRNOP00000009096
Ensembl nucleotide ID ENSRNOG00000006681
Gene name Retinol dehydrogenase 10
Gene symbol Rdh10
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.
Sequence
MNIVVEFFLV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR LFALEFARRR 60
ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG EEEILPPCNL QVFTYTCDVG 120
KRENVYLTAE RVRKEVGEVS VLVNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF 180
LPTMLEINHG HIVTVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL 240
VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK 300
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I 341

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRDH10282852Q8HZT6Bos taurusPredictionMore>>
1:1 orthologRDH10486998E2R0Q8Canis lupus familiarisPredictionMore>>
1:1 orthologRDH10102180778A0A452EW84Capra hircusPredictionMore>>
1:1 orthologRDH10157506Q8IZV5Homo sapiensPredictionMore>>
1:1 orthologRdh1098711Q8VCH7CPOMus musculusPublicationMore>>
1:1 orthologRDH10472795H2QWA8Pan troglodytesPredictionMore>>
1:1 orthologRDH10A0A286ZUS8Sus scrofaPredictionMore>>
1:1 orthologRDH10100340133G1SV43Oryctolagus cuniculusPredictionMore>>
1:1 orthologRdh10353252Q80ZF7Rattus norvegicusPredictionMore>>
1:1 orthologrdh10aF1RES0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0005811 lipid droplet
GO:0016020 membrane
GO:0052650 NADP-retinol dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0004745 retinol dehydrogenase activity
GO:0009887 animal organ morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0043583 ear development
GO:0031076 embryonic camera-type eye development
GO:0035115 embryonic forelimb morphogenesis
GO:0048568 embryonic organ development
GO:0048703 embryonic viscerocranium morphogenesis
GO:0008406 gonad development
GO:0001701 in utero embryonic development
GO:0001656 metanephros development
GO:0014032 neural crest cell development
GO:0043584 nose development
GO:1900054 positive regulation of retinoic acid biosynthetic process
GO:0060431 primary lung bud formation
GO:0042574 retinal metabolic process
GO:0002138 retinoic acid biosynthetic process
GO:0042572 retinol metabolic process
GO:0007601 visual perception

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0256 Endoplasmic reticulum
KW-0472 Membrane
KW-0492 Microsome
KW-0521 NADP
KW-0560 Oxidoreductase
KW-1185 Reference proteome
KW-0735 Signal-anchor
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR036291 NAD(P)-bd_dom_sf
IPR032970 RDH10
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

PROSITE

PROSITE ID PROSITE Term
PS00061 ADH_SHORT

Pfam

Pfam ID Pfam Term
PF00106 adh_short